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A sample of 229 nearby thick disk stars has been used to investigate theexistence of an age-metallicity relation (AMR) in the Galactic thickdisk. The results indicate that that there is indeed an age-metallicityrelation present in the thick disk. By dividing the stellar sample intosub-groups, separated by 0.1 dex in metallicity, we show that the medianage decreases by about 5-7 Gyr when going from
We studied the effect of habitat fragmentation on female reproductive investment in a widespread lacertid lizard (Psammodromus algirus) in a mixed-forest archipelago of deciduous and evergreen oak woods in northern Spain. We captured gravid females in fragments (<= 10 ha) and forests (>= 200 ha) and brought them to the laboratory, where they laid their eggs. We incubated the eggs and released the
Medical geography usually attempts to disentangle and explain the ecological and causal contexts of health, disease and environment by mapping spatial patterns of cases and potential pathogenic factors. However, many diseases are believed to show after long periods of latency , spanning years and even decades between initial exposure and clinical onset. In view of high spatial human mobility - in
Background/Aims: Budesonide controlled-release (CR) capsules are effective for inducing remission of Crohn's disease (CD) and are associated with fewer side effects than conventional corticosteroids. A compassionate-use program was implemented in countries where this treatment was unavailable. This paper reports the findings of this program. Methodology: Physicians were allowed to apply to AstraZe
Neuropeptide Y is a sympathetic co-neurotransmitter released with noradrenaline upon sympathetic nerve stimulation. This study describes the ability of a synthetic inositol phosphate, alpha-trinositol(D-myo-inositol 1,2,6-triphosphate; PP 56) to antagonize vasoconstrictor responses to neuropeptide Y in-vitro as well as in-vivo. In human and guinea-pig isolated arteries alpha-trinositol potently (1
Earlier detailed studies of cnidarian planula larvae have revealed a simple nervous system but no eyes or identifiable light sensing structures. Here, we describe the planula of a box jellyfish, Tripedalia cystophora, and report that these larvae have an extremely simple organization with no nervous system at all. Their only advanced feature is the presence of 10-15 pigment-cup ocelli, evenly spac
In this article, some of the possibilities and obstacles involved in attaining stable peace in the Baltic Sea region are analysed. By stable peace is understood a relationship in which military conflict resolution has become unthinkable regardless of how serious a prospective conflict may become. It is argued that stable peace does not presently exist in the region as a whole, but that instead the
The purpose of this paper is to provide a research outlook on the concept of decentralized freight intelligence, i.e. autonomous freight making localized routing decisions. A review of research literature on decentralized intelligence in freight transport serves as the foundation of the analysis. The analysis reveals a scarcity of scientific evidence to suggest a successful introduction of decentr
Weak economic growth is a contributing factor behind many banking crises. In this paper, we test whether banking crises cause long-term institutional change aimed at improving macroeconomic performance and thus indirectly reduce the risk of future crises. Our dataset consists of 22 developed and 34 developing countries covering the period from 1985 to 2009. The results show that banking crises cau
The major input signals entering the PID controller are: the setpoint, the process output, and measurable load disturbances. By feeding these signals through suitable filters, the properties of the feedback loop can be improved significantly. The goal of this paper is to provide a unified discussion about these filters. The paper treats set-point handling, feedforward from load disturbances, TITO
Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their el
Purpose: We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in ovarian cancer via abrogation of a tumor-promoting cytokine network. Experimental Design: We combined preclinical and in silico experiments with a phase 2 clinical trial of the anti-IL-6 antibody siltuximab in patients with platinum-resistant ovarian cancer. Results: Automated immunohistochemistry on ti
Two subspecies of Helianthemum nummularium (L.) Mill. occur in southern Scandinavia. The key character distinguishing the two subspecies is a dense cover of stellate hairs on the abaxial surface of the leaves in subsp. nummularium that are not found in subsp. obscurum. Stellate hairs on the abaxial surface of the leaves are not a discrete character, but occur in a more or less continuous range fro
In Europe an increasing number of scholars from different disciplines show growing interest in studying interactions between society and wildlife. Europe’s diversity with regard to cultures, languages and governance systems for wildlife is reflected in the wealth of research perspectives on human-wildlife interactions. Today a variety of approaches, disciplinary perspectives, theoretical framework
In Europe postgraduate training to become a geriatrician is regulated by national governments. To gain some insight how these regulations work in practice students of the Xth EAMA Postgraduate Course in Geriatrics prepared a presentation on how to become a geriatrician in their country. This article summarizes and compares the given information of 16 European countries illustrating an extensive di
This chapter reflects on the relationship between various stakeholders in the health-care industry and intelligent medical systems. It takes into consideration the potential impact that intelligent systems have on health care. The aim of the chapter is to emphasise a set of decisive factors for the successful deployment of intelligent systems in health care including the individual needs of patien
