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Urine-metanephrines are used in the screening for pheochromocytomas in patients with adrenal incidentalomas, but their potential as markers for mortality in patients with adrenal adenomas has not been studied. A retrospective cohort study was designed to investigate if urine-metanephrines were associated with mortality in patients with adrenal adenomas. Participants where consecutively included be
Majorana modes can be engineered in arrays where quantum dots (QDs) are coupled via grounded superconductors, effectively realizing an artificial Kitaev chain. Minimal Kitaev chains, composed by two QDs, can host fully localized Majorana modes at discrete points in parameter space, known as Majorana sweet spots. Unlike grounded superconductors, where the superconducting phase is a conserved quantu
Abstract We test a novel, stochastic model of osmotic water transport in aquaporins. A solute molecule present at the pore mouth can either be reflected or permeate the pore. We assume that only reflected solute molecules induce osmotic transport of water through the pore, while permeating solute molecules give rise to no water transport. Accordingly, the rate of water transport is proportional t
A recently observed Kπ = 1+ mode in deformed nuclei is studied microscopically. By calculating the energies, the B(M1)-values and the form-factors of inelastic electron scattering for 156Gd, we conclude that the relatively strong M1-strength observed at 3.075 MeV comes predominantly from the convection current of proton excitations in the Oh 1 2-orbit. We suggest a search for the M1-strength aroun
Introduction: Most neurodegenerative diseases, including Alzheimer's disease (AD) and multiple sclerosis (MS), feature abnormal tau phosphorylation (p-tau) in the brain. Prior immunostaining studies have shown p-tau accumulation in the AD retina, suggesting it may mirror brain tau pathology. Methods: We used mass spectrometry to quantify p-tau peptides in matched retinal and hippocampal samples fr
Rapid developments in animal-tracking technology have enabled major advances in the field of movement ecology, which seeks to understand the drivers and consequences of movement across scales, taxa, and ecosystems. The field has made ground-breaking discoveries, yet the majority of studies in movement ecology remain reliant on observational approaches. While important, observational studies are li
With their superficially shark-like appearance, the Mesozoic ichthyosaurs provide a classic illustration of major morphological adaptations in an ancestrally terrestrial tetrapod lineage following the invasion of marine habitats1, 2–3. Much of what is known about ichthyosaur soft tissues derives from specimens with body outlines4, 5–6. However, despite offering insights into aspects of biology tha
Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397–1415) reveal HROB as a new player in HR required for recruitment of the MCM8–9 complex, which is paralogous to the MCM2–7 replicative helicase. HR
BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is a rare cardiac disorder that predispose to supraventricular arrhythmias. Prognosis is usually benign, yet there is an increased lifetime risk of sudden death. While typically sporadic, familial clustering has been reported. This study aimed to assess the risk of WPW, arrhythmias, and mortality among siblings of individuals with WPW.METHODS: This
Decisions made by millions of refugees about where to go, how to make a living and how to secure a future are fundamental drivers of secondary movements. While a substantial body of literature addresses factors contributing to migrants’ decision-making, a comprehensive understanding of the central role of refugees in secondary mobility decision-making, including agency and strategies employed, rem
Denna avhandling handlar om hur arkitektur producerar normer genom hållbar stadsutveckling, från formulering av visioner och strategier till materialisering och design. Den handlar också om arkitekturens potentiella roll i att omförhandla och utmana den normativt utstakade vägen framåt, till förmån för alternativa förhållningssätt. Hållbar stadsutveckling beskrivs i avhandlingen som en typologi avArchitecture, planning and urban design are some of the professional practices that contribute to the spatial aspects of societal organization and enable everyday life to run smoothly. The urgent and intertwined challenges of climate change and social injustice have introduced new dimensions to these tasks, frequently framed as working towards ‘sustainable development.’ In this doctoral thesis, I
Duplication of PLP1 (proteolipid protein gene 1) and the subsequent overexpression of the myelin protein PLP (also known as DM20) in oligodendrocytes is the most frequent cause of Pelizaeus-Merzbacher disease (PMD), a fatal leukodystrophy without therapeutic options. PLP binds cholesterol and is contained within membrane lipid raft microdomains. Cholesterol availability is the rate-limiting factor
The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controll
Background Gender discrimination of women is often emphasized in work contexts, whereas less focus is on how men are discriminated against in social relationships. Gender discrimination in decisions of family relations, is essential to study as the contact between parent and child is commonly viewed as the most important relationship in people’s life, as well as being the most important aspect of
The tumor microenvironment (TME) is composed of various cellular components such as tumor cells, stromal cells including fibroblasts, adipocytes, mast cells, lymphatic vascular cells and infiltrating immune cells, macrophages, dendritic cells and lymphocytes. The intricate interplay between these cells influences tumor growth, metastasis and therapy failure. Significant advancements in breast canc
For a century, transport systems have been governed by masculine norms, constraining both women and men within the conditions and mobility behaviour it has established. This article explores the potential implications of adopting feminine norms for mobility and transport systems. Current masculine mobility norms are contested by investigating what including a feminine mobility concept would entail
The transition towards a circular economy (CE)relies on a supporting policy framework. TheEU is currently recognised as a global leader inclimate action and has adopted a comprehensivepolicy package to reach the objectives set outin its Circular Economy Action Plan. This paperexamines current and planned CE policies, theirkey impact on industries – with a focus on es-tablished manufacturing indust
Timely light exposure is a vital aspect to achieve better sleep and well-being. As there are risks with a disturbed circadian rhythm and benefits with light settings that stimulate the rhythm, the circadian effective light, circadian stimulus (CS), for radiographers was examined. Aim: The aim of the study was to compare radiographers’ light environment on the workstations, at a university hospital
On December 9, 2016, South Korea's National Assembly voted to impeach the country's president, Park Geun-hye, over abuse of power among other charges. Three months later, the Constitutional Court upheld the impeachment and she was dismissed from office-the first South Korean president to be removed this way. New elections were called. Park was then made the subject of a criminal investigation and
