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For real time embedded systems software performance is one of the most important quality attributes. Controlling and predicting the software performance in software is associated with a number of challenges. One of the challenges is to tailor the established and rather general performance activities to the needs and available opportunities of a specific organization. This study presents a qualitat
Urinary tract infections (UTIs) are associated with significant morbidity and high frequency of antibiotic prescription. Diagnosing UTI is often difficult, particularly in the critically ill patient and in patients with unspecific and mild symptoms. The standard rapid tests have limited value, and there is a need for more reliable diagnostic tools. Heparin-binding protein (HBP) is released from ne
BACKGROUND: Radiography alone will not detect all scaphoid fractures. There is a reported prevalence between 9 and 33% of occult scaphoid fractures. The evidence-based literature suggests that magnetic resonance imaging (MRI) is the most suitable secondary imaging modality due to the ability to evaluate the bone marrow directly and to also identify other injuries. However, there is no consensus on
PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-
Next generation sequencing of uveal melanoma (UM) samples has identified a number of recurrent oncogenic or loss-of-function mutations in key driver genes including: GNAQ, GNA11, EIF1AX, SF3B1 and BAP1. To search for additional driver mutations in this tumor type we carried out whole-genome or whole-exome sequencing of 28 tumors or primary cell lines. These samples have a low mutation burden, with
Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences
This study examined human listeners’ ability to classify domestic cat vocalisations (meows) recorded in two different contexts; during feeding time (food related meows) and while waiting to visit a veterinarian (vet related meows). A pitch analysis showed a tendency for food related meows to have rising F0 contours, while vet related meows tended to have more falling F0 contours. 30 listeners judg
A number of microorganisms are capable of binding immunoglobulins (Igs) in a manner, which excludes binding to conventional antigen binding sites. Interaction of such bacterial proteins with surface immunoglobulins leads to polyclonal activation of B-lymphocytes. A recent example is Moraxella catarrhalis that binds to B lymphocytes in an IgD-dependent manner and induces proliferation and different
Abstract in Chinese 中文语用标记语"吧"的关联理论分析 Marita Ljungqvist 瑞典隆德大学 摘要 本文以关联理论为依据试图对汉语句末助词”吧”的用法进行全面的解释与分析。 结果表明，”吧” 在陈述句、疑问句与祈使句都具有类似的用法，即表示说话者面向听话者对自己表达的命题(陈述句、疑问句) 或言语行为(祈使句)之承诺。结果还表明”吧”有时同英文的像 yeah 、right 、innit 类似的所谓”tags” 的词语一样 起着鼓励听话者更积极/投入地参加会话的作用。 在这种语境里”吧”的出现表示礼貌而不一定意味着说话者要听话者回应或确认命题的真实价值。 关键词 句未助词、语用学、关联理论This paper aims to present a proposal for a relevance-theoretic description of the use of the particle ba in Mandarin Chinese. The result of the analyses of the data shows that ba is a pragmatic marker with a similar function in declaratives, interrogatives and imperatives, i.e. to indicate hearer-oriented weak commitment towards either the proposition expressed (declaratives, interrogatives) or t
Abstract is not available
BACKGROUND: Clinical trials implicate the estrogen receptor (ER) coactivator amplified in breast cancer 1 (AIB1) to be a prognostic and a treatment-predictive factor, although results are not unanimous. We have further investigated this using a controlled randomised trial of tamoxifen versus control. Materials and methods: A total of 564 premenopausal women were entered into a randomised study ind
This dissertation is a contribution to the debate about ‘climate justice’, i.e. a call for a just and feasible distribution of responsibility for addressing climate change. The main argument is a proposal for a cautious, practicable, and necessary step in the right direction: given the set of theoretical and practical obstacles to climate justice, we must begin by making contemporary development p
Today one could argue that most of the logistics research available has a strong connection to the positivistic paradigm where there is a great emphasis on simplicity in both the research conducted and in the solutions produced. The overall ability to design, plan and control is promoted by the researchers to a great extent. Consequently, firms invest money, time and resources in solutions, based
