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A lack of empathy, and particularly its affective components, is a core symptom of behavioural variant frontotemporal dementia (bvFTD). Visual exposure to images of a needle pricking a hand (pain condition) and Q-tips touching a hand (control condition) is an established functional magnetic resonance imaging (fMRI) paradigm used to investigate empathy for pain (EFP; pain condition minus control co
Real wages are a convenient, useful, and powerful way to learn how life was like in the past. In this chapter we start by reviewing the methodology behind real wage estimations and their history. Then we look at the how real wages have contributed to shedding light on major issues in economic history such as the onset of modern economic growth, the Great Divergence, and colonialism in the Americas
Conventional social mobility research misses substantial inequalities of opportunity. To capture intergenerational persistence of family social status, we need to move beyond parent-child associations in occupation or income. We study the inheritance of surname status as a group-level process, using full-count population data for Swedish men between 1880 and 2015 and surname types reflecting prein
Objectives: SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss-of-function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes. Here we describe a novel dominant variant in SLC4A4 in patients wit
Preventing obsessive–compulsive disorder (OCD) before it emerges has long been considered a central, yet elusive, goal for researchers. Achieving this will likely require identifying individuals at elevated risk and intervening during critical developmental periods before the onset of impairing symptoms. This trial evaluated the feasibility of a brief parent-guided online targeted prevention progr
The goal of this thesis is to answer the question what is the probability that the U.S. economy will experience a recession and a concomitant financial crisis in the near future. The question is answered through the use of a probit model, in which five explanatory variables, derived from previous research, are processed. The variables are Current Account to GDP, NYSE Composite Index, Domestic Cred
The European Union is developing a common asylum system. The goal is to create certain minimum standards regulating the reception and procedures regarding asylum seekers and refugees. The Dublin II Regulation is one of the legal instruments created in this process. It determines which state is responsible for any particular asylum seeker and for their asylum application. The member state that allo
Charting the conversation between Robert N. Bellah and Martin E. Marty in which the concept of public theology was coined, this chapter contends that public theologies have been haunted by a ghost – the ghost of theological liberalism, concretized in Paul Tillich. Instead of casting out the ghost, however, the chapter re-claims this legacy in order to carve out the contours of a criterion that all
The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders 1–4, but attempts to assess constraint for non-protein-coding regions have proved more difficult. Here we aggregate, process and release a dataset of 76,156 human genomes from the Genome Aggregation Database (gnomAD)—the larges
This article discusses the role of mathematics during physics lessons in upper-secondary school. Mathematics is an inherent part of theoretical models in physics and makes powerful predictions of natural phenomena possible. Ability to use both theoretical models and mathematics is central in physics. This paper takes as a starting point that the relations made during physics lessons between the th
Haemophilia A (HA) is a hereditary bleeding disorder, characterised by deficiency of coagulation factor VIII (FVIII). Repeated joint bleeds can lead to permanent joint damage. FVIII replacement therapy has a high cost and can reduce but not completely prevent bleeding. This thesis aims to promote personalised treatment and optimised outcomes through a clinical and pharmacokinetic characterisation.
This paper introduces the MinCan database that presents mine-level estimates for the Canadian mining industry with a persistent annual coverage between 1950 and 2022. These estimates are based on archival maps and a selection of historical sources, which follows a hierarchy of criteria-based credibility and standardization. The information contained in MinCan covers 947 mines and provides informat
Earlier this year, authorities in the Xinjiang Uyghur Autonomous Region passed a revised version of the Xinjiang Regulations on Religious Affairs. The new rules emphasize the Sinicization of religion, ensuring that sites of religious worship, like mosques, reflect “Chinese characteristics and style.” Moreover, they are calling for the cultivation of “patriotic” religious leaders. Despite enshrinin
BACKGROUND: Polycystic ovary syndrome (PCOS) has previously been associated with several comorbidities that may have shared genetic, epigenetic, developmental or environmental origins. PCOS may be influenced by prenatal androgen excess, poor intrauterine or childhood environmental factors, childhood obesity and learned health risk behaviors. We analyzed the association between PCOS and several rel
Objectives To describe clinical and laboratory characteristics and outcomes in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and thyroid disease (TD). We also aimed to calculate incidence and identify predictors of TD in two large cohorts of patients with AAV. Methods The study comprised 644 patients with AAV in a population-based cohort from southern Sweden
Background: Allergic contact dermatitis (ACD) from rubber glove usage is usually caused by rubber additives such as the accelerators. However, in analyses of the suspected gloves, ordinary rubber allergens are not always found. Accelerator-free rubber gloves are available, but some patients with accelerator allergy do not tolerate them and might also be patch test positive to them. Objectives: To
