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Background & aims: Tea has been shown to be associated with reduced risk of several diseases including cardiovascular diseases, stroke, metabolic syndrome, and obesity. However, the results on the relationship between tea consumption and bladder cancer are conflicting. This research aimed to assess the association between tea consumption and risk of bladder cancer using a pooled analysis of pr

OBJECTIVES: To explore and compare the prevalences of a wide range of comorbidities in axial spondyloarthritis (axSpA) versus the general population, and in non-radiographic versus radiographic axSpA (nr-axSpA/r-axSpA).METHOD: Well-characterized axSpA patients (n = 246) from the SPARTAKUS cohort (55% men; mean age/disease duration 52/26 years; nr-axSpA/r-axSpA = 82/164) were included, and matched

INTRODUCTION: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally.METHODS: A pre-planned analysis of the European Society of Coloproct

Aim: To evaluate whether history of pregnancy complications [pre-eclampsia, gestational hypertension, preterm delivery, or small for gestational age (SGA)] improves risk prediction for cardiovascular disease (CVD).Methods and results: This population-based, prospective cohort study linked data from the HUNT Study, Medical Birth Registry of Norway, validated hospital records, and Norwegian Cause of

Background/Aims: To identify prodromal Alzheimer's disease (AD) subjects using a data-driven approach to determine cognitive profiles in mild cognitive impairment (MCI). Methods: A total of 881 MCI subjects were recruited from 20 memory clinics and followed for up to 5 years. Outcome measures included cognitive variables, conversion to AD, and biomarkers (e. g. CSF, and MRI markers). Two hierarchi

Popular Abstract in Swedish VADÅ CYTOTOXISKA OCH PROINFLAMMATORISKA EGENSKAPER HOS EOSINOFILA? Vårt immunförsvar är nödvändigt för vår överlevnad, men des's komplexitet gör det svårt att greppa. Man brukar dela upp det i ett ospecifikt och ett specifikt försvar. T och B celler ingår i det ospecifika och vita blodkroppar i det specifika. En andra uppdelning är första försvarslinjen (den barriär soEosinophils are multi-functional leukocytes involved in the pathophysiology of inflammatory diseases such as asthma and inflammatory bowel disease. Participation in some neoplastic diseases and in the host defense against helminths has also been postulated. They are considered both good and bad, protecting or harming the host. The exact roles of eosinophils and their mechanisms of action are poorl

The purpose of the study was to (1) observe the frequency of giving way to pedestrians at the zebra crossing, (2) reveal speed adaptation problems, (3) examine if the time difference between the arrival of the pedestrian and the car have any influence on the speed of the approaching car, (4) identify so-called “ideal” situations (in which the car brakes on the driver’s own initiative in order to g

Popular Abstract in Swedish Malaria parasiter skördar årligen runt 2 miljoner liv i regionerna söder om Sahara. De parasiter som orsakar malaria hos människor ingår i en stor grupp av blodparasiter som återfinns hos primater, reptiler, fladdermöss och fåglar. För att dessa parasiter ska kunna genomgå hela sin livscykel både ett ryggradsdjur och en blodsugande insekt (en vektor). I de blodsugande iMalaria-like parasites consist of a large group of species that infects primates, rodents, bats, lizard and birds. I have focused on parasites from the genera Haemoproteus, Plasmodium and Leucocytozoon that are infecting birds. By using molecular methods to identify parasites from avian blood samples, I have found a diversity, based on the cytochrome b gene, that greatly exceeds the diversity prev

BACKGROUND: Hippocampal decrease in size in response to posttraumatic stress disorder (PTSD) is still a subject of controversy. The aims of this study were to: (1) confirm previous hippocampus findings in PTSD patients compared to controls, using ethnically similar study groups where alcohol and drug abuse were non-existent; (2) test influence of disease duration as well as depression scores on po

Great Snipes Gallinago media spend about eight months per year in sub-Saharan Africa, but most aspects of their non-breeding ecology are poorly known. We analysed the seasonal pattern of appearance, flight feather moult (primaries and secondaries), and body mass in relation to age and sex, based on 3,247 birds collected by hunters in 1990–2000 in Benin, Gabon, Cameroon and the Democratic Republic

The Silurian was a time of major climatic transition punctuated by multiple biotic crises and global carbon cycle perturbations. The most severe of these biotic events was the late Silurian (Ludfordian) Lau/Kozlowskii extinction event (LKE) and the associated Lau carbon isotope excursion (CIE). Although the extinction event and Lau CIE are globally documented, the only records thus far of local an

Background: DNA methylation and gene expression are promising biomarkers of various cancers, including non-small cell lung cancer (NSCLC). Besides the main effects of biomarkers, the progression of complex diseases is also influenced by gene-gene (G×G) interactions. Research Question: Would screening the functional capacity of biomarkers on the basis of main effects or interactions, using multiomi

Background: Human intratumoral T cell infiltrates can be defined by quantitative or qualitative features, such as their ability to recognize autologous tumor antigens. In this study, we reproduced the tumor-T cell interactions of individual patients to determine and compared the qualitative characteristics of intratumoral T cell infiltrates across multiple tumor types. Methods: We employed 187 pai

Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial. Genetic studies can help dissect causal directions of epidemiological associations because genotypes are much less likely to be confounded, biased or influenced by disea

BACKGROUND: Diffuse traumatic axonal injury (TAI), a common consequence of traumatic brain injury, is associated with high morbidity and mortality. Inflammatory processes may play an important role in the pathophysiology of TAI. In the central fluid percussion injury (cFPI) TAI model in mice, the neuroinflammatory and astroglial response and behavioral changes are unknown.METHODS: Twenty cFPI-inju

Previous studies have indicated that hereditary prostate cancer is common among men with early onset prostate cancer. The aim of this study was to investigate the incidence of malignant tumours in first-degree relatives of men with early onset prostate cancer. All prostate cancer cases diagnosed before the age of 51 years from 1958 to 1994 were identified in the population-based Swedish Cancer Reg

Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. The focus in this thesis lies on the effect of prognosti

BACKGROUND: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, typ

Popular Abstract in Swedish Svenska räkneord behandlas här ur olika synvinklar. Boken är inte tänkt som en lärobok om svenska räkneord, även om man kan lära sig en hel del om systemet här - mer än språkanvändaren i allmänhet känner till. Fonologi, morfologi, syntax och semantik får alla sin del av uppmärksamheten. Jag undersöker räkneordssystemet som en synkron helhet, men de historiska förhållandSwedish numerals are here treated from different points of view. The book is however not intended to be a textbook of Swedish numerals, though one may learn a great deal about the system herein - more than the general user of the language knows. Phonology, morphology, syntax and semantics all get their fair share of attention. I am investigating the numeral system as a synchronic whole (and simila

Solid tumors exhibit chromosomal rearrangements resulting in gain or loss of multiple chromosomal loci (copy number variation, or CNV), and translocations that occasionally result in the creation of novel chimeric genes. In the case of breast cancer, although most individual tumors each have unique CNV landscape, the breakpoints, as measured over large datasets, appear to be non-randomly distribut