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Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.

Genetic and environmental factors, including the commensal microbiota, have a crucial role in the development of inflammatory bowel disease. Aberrant activation of the transcription factor NF-κB is associated with chronic intestinal inflammation in mice and humans. Recently, an emerging family of innate lymphoid cells (ILCs) has been identified at mucosal sites contributing to the maintenance of g

Feeding Strategies Based on Probing Control for E. coli and V. cholerae Cultivations

Popular Abstract in Swedish Många olika proteiner kan produceras med hjälp av rekombinanta DNA tekniker. Ofta sätts vektorn som kodar för det rekombinanta proteinet in i bakterien E. coli, då den är välkänd. Det är viktigt att producera mycket celler för att uppnå hög produktivitet. Detta görs genom att näringsämnet (ofta glukos) tillsätts kontinuerligt till en så kallad semisats reaktor. TillsatsThe recombinant DNA techniques have made it possible to produce many different proteins for a wide range of applications. The vector encoding for the recombinant protein is often inserted in the bacterium E. coli as it is a well studied and a well-known organism. To achieve a high productivity, it is important to reach a high cell density. This is obtained through fed-batch operation where the nut

Development of Transgenic Potatoes to Attain Novel Starch Qualities

Starch is a plant-derived polysaccharide with many uses in different food and non-food applications. In this thesis, the production of two novel potato starch qualities, amylopectin and high-amylose, and the modifications and the characteristics of the produced plants and starches are described. The novel potato starch qualities will find uses in e.g. the paper, adhesive, textile and packing indus

Navigating ESG Impact: A Comparative Study of Investment Strategies within the DAX Index companies

This thesis examines the relationship between Environmental Social and Governance (ESG) factors and investment strategies. Specifically, it focuses on how ESG scores can influence investment decisions within companies listed on the DAX Index, the benchmark German stock market index. Using Granger causality on individual companies from the DAX and on portfolios built on the ESG score of companies w

Exploring the acceptability of a blanket Post-Exposure Prophylaxis (PEP) approach for Leprosy prevention in Achham, Nepal

This thesis explores the implementation and acceptability of blanket (population-wide coverage of active case finding and prevention) Post-Exposure Prophylaxis (PEP) as a preventive measure for leprosy transmission in the Achham district of Sudurpaschim (Far-west) Province in Nepal. Leprosy remains a significant public health concern in Nepal, with persistent challenges in prevention and control e

Tillsyn av förskolor i Lomma Kommun- En uppföljning av hygienprojekt och egenkontroll

Förskolorna måste göra mer på hälsoskyddsområdet än att lära barn tvätta händerna Samtliga förskolor i Lomma Kommun har under 2012 och 2013 inspekterats av miljökontoret för att följa upp Socialstyrelsens projekt om hygien och smittskydd i förskolan från 2009. Resultatet visar att de 24 förskolorna i Lomma Kommun har bra rutiner för hygien, smittskydd och städning. Andra områden som krävs enligStudies have showed that children that are spending their daytime at preschools suffer from more infections than children who stay at home. The indoor environment has a big impact on our health and therefore it must be good and suitable for the children in preschools. According to the Swedish environmental laws preschools must set- up preventive work to avoid environmental and health problems an

Nuclear Fuel Bundle Design Optimization using a Simplex Method

En kokvattenreaktor är en typ av kärnkraftverk där energi frigörs genom fission i uranstavar arrangerade i bränsleknippen. Genom reaktorn strömmar vatten vilket genom den intensiva värmeutvecklingen från uranstavarna kokar, den bildade vattenångan driver sedan via ångturbiner elektriska generatorer. Att bestämma en nukleär design, d.v.s. en distribution av urananrikningar och brännbar absorbator, A strategy for nuclear fuel bundle design optimization in boiling water reactors(BWRs), using a simplex method, is presented and examined. The objective of the study is to see how an automatic optimization scheme can create nuclear designs for use in BWR fuel bundles and how the scheme can be improved. Challenges with applying linear simplex optimization to non-linear bundle physics lie in approx

We are not idealists: A qualitative case study on the role of residents’ climate change concerns in rural mobility practices

Påverkar det vort transportval när vi bekymrar oss om klimatet? När vanliga människor oroar sig om klimatförändringen har det betydning för hur dom uppfattar sin transport i vardagen. Klimatbekymringen spelar i denna studie ingen avgörande roll för om folk väljer bil, bus eller cykel. Men ändå påverkas t. ex. synen på olika transportformer och känslan för vad som är ett individuellt ansvar. KlimaCitizens concerned about climate change could represent a potential for changes in everyday travel behaviour in a less carbon intensive way, or even put public pressure on governmental decisions to mitigate climate change emissions from the transport sector. Situated in the context of rural residents’ everyday life in Denmark, this study explores how the role of climate change concerns within resi

Att göra en snygg entré - en fallstudie av Starbucks inträde på nationella marknader

Purpose: To investigate whether our case company's entry mode decisions can be understood and explained by existing literature on choice of entry modes and national barriers to entry. Methodogy:A case study has been chosen as the main research design; we investigate our case firm thoroughly. At the same time we study the national markets Starbucks has entered with focus on the national barrier

PVC flooring at home and development of asthma among young children in Sweden, a 10-year follow-up

The incidence of asthma and allergy has increased throughout the developed world over the past decades. During the same period of time, the use of industrial chemicals such as phthalates, commonly used as plasticizers in polyvinylchloride (PVC) flooring material, has increased. The aim of this study was to investigate whether PVC flooring in the home of children in the age of 1-5years is associate

Swedish Municipalities & New Nuclear Power: Perceptions, Planning & Decision-Making Processes

Swedish municipalities are placed in a decision-making position as the nation looks to bolster the nation's energy strategy with increased nuclear power. New nuclear power is posed as an exciting potential solution to the energy crisis and the need for more decarbonized energy sources. New nuclear power also consists of uncertainty, emerging technologies, and planning difficulties. This thesis

A Day By the Beach - Reimagining Coastal Tourism in the Age of Climate Change, Sri Lanka

As climate change accelerates, rising sea levels and eroding shorelines are reshaping our coastal landscapes. Short-term fixes, such as beach nourishment and offshore breakwaters, are proving increasingly ineffective and costly. In nations like Sri Lanka, where tourism is a vital pillar of the economy and heavily dependent on beaches, these transient measures have become financially unsustainable.

Improvisation - ett pedagogiskt perspektiv

Title: Improvisation ? a pedagogical perspective. This investigation studies how church musicians and pianists describe the use of improvisation in their teaching. The research questions focus on the relationship between improvisation and interpretation, the aim how to use improvisation and how this could be realized. To get the answer of these questions, I have interviewed two organists and two p

Faktorer som kan påverka förmågebedömning – med avseende på kommunala risk- och sårbarhetsanalyser

This report constitutes that there are factors that may affect capacity assessment within municipal risk- and vulnerability analysis. The scope is an interview survey investigating the attitudes of operators within the municipal emergency preparedness towards factors that could potentially affect the outcome of capacity assessment. Six Influencing factors are identified comprising; 1 Selection re

Kan grupprättigheter rättfärdigas? En normativt jämförande studie av fyra liberalistiska teoretiker och deras argumentation om grupprättigheter

The purpose of this essay is to compare point of views from four different liberal scholars concerning multiculturalism and group recognition. As well as to investigate if there are any conflicts between liberal values like liberty, equality and self-determination. The material is based on Will Kymlicka, Susan Moller Okin, Joseph Raz and Chandran Kukathas ideas about liberalism, multiculturalism a

Stadens struktur : varför och hur?

Popular Abstract in Swedish Varför ser staden ut som den gör? Vilka krafter ligger bakom bebyggelsens och transportsystemets utformning? Vad eller vilka aktörer har inflytande över hur staden utformas? Hur kan internationella olikheter i städers utformning förklaras? De krafter som formar staden är många och komplexa. Stadens struktur har under historiens gång påverkats av bland annat nya teknologWhy do cities appear the way they do? What are the underlying forces that contribute to its built environment and transport system? What/whom are the factors/actors that influence the ways in which the city is shaped? How can the international differences in the shape of cities be explained? The driving forces that shape the city are numerous and complex. City structure, has through the ages, been

Genetic variability and cadmium metabolism and toxicity

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Kadmium är en giftig metall vilken finns i mat som vi rekommenderas äta mycket av, exempelvis sädesprodukter, grönsaker och skaldjur. Våra matjordar är kontaminerade med kadmium och föroreningen kommer att kvarstå under mycket lång tid framöver. Kadmium skadar framförallt njurarna och skelettet och kan antagligen även orsaAbstract: Cadmium (Cd) is ubiquitous in the environment. Human exposure in non-smokers occurs mainly via intake of healthy food like vegetables, cereals, and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. There is considerable inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of C

JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination.

Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse