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Many individuals with intermediate hyperglycaemia (IH), including impaired fasting glycaemia (IFG) and impaired glucose tolerance (IGT), as presently defined, will progress to type 2 diabetes (T2D). There is confirmatory evidence that T2D can be prevented by lifestyle modification and/or medications, in people with IGT diagnosed by 2-h plasma glucose (PG) during a 75-gram oral glucose tolerance te

BACKGROUND: The long-term effects of adjuvant polychemotherapy regimens in oestrogen-receptor-poor (ER-poor) breast cancer, and the extent to which these effects are modified by age or tamoxifen use, can be assessed by an updated meta-analysis of individual patient data from randomised trials.METHODS: Collaborative meta-analyses of individual patient data for about 6000 women with ER-poor breast c

Popular Abstract in Swedish För tidigt födda barn genomgår intensivvård under en period när de är väldigt sårbara pga instabil cirkulation och ett omoget centralt nervsystem under snabb utveckling. Tillräcklig behandling av smärta är av största betydelse eftersom stark smärtupplevelse kan medföra skadliga omedelbara kroppsreaktioner, men också neurologiska och neuropsykologiska seneffekter. Det fiPreterm infants undergo intensive care during a vulnerable period with hemodynamic instability and a rapidly developing and immature CNS. Adequate pain management is essential, since pain experience might lead to acute physiological reactions as well as neurological and neuropsychological sequels. There is no “golden standard” for objective pain assessment, and no evidence-based recommendations fo

Popular AbstractAvsikten med denna avhandling är att utveckla en teori om de försvårade villkor som män ur arbetarklassen och den lägre medelklassen upplevt i Ronneby sedan början av 1900-talet; om hur traditionen att snabbt komma ut i arbetslivet — som bland män i Ronneby i det närmaste har varit likvärdigt med att bli vuxen — ersatts av ett behov att senarelägga vuxenblivandet. Bakgrunden är attThe place is Ronneby, a smallish town in southern Sweden. My subjects are working class and lower middle class men in Ronneby, men who — since the beginning of the century — have encountered changing conditions for reaching adulthood. In this dissertation, I will analyse these changing and increasingly difficult conditions and try to explain how the tradition of starting to work early in life, and

Background. Randomized trials have shown that icodextrin reduces the volume of extra-cellular fluid (ECFv) with variable effects on residual renal function. To explore this fluid shift and its possible mechanisms in more detail, prospectively collected data from one such trial, including measures of inflammation (C-reactive protein, tumor necrosis factor-a, albumin and low and high molecular weigh

Popular Abstract in Swedish Ur ett evolutionärt perspektiv har förmågan att lagra energi varit fördelaktig när tillgången på föda varit begränsad. I våra dagar i västvärlden råder det ingen brist på mat och vår förmåga att lagra energi har istället blivit en börda i dubbel bemärkelse. Energi lagras i kroppen framförallt i form av fett, s.k. triglycerider. Övervikt och fetma kan idag sägas utgöra eHormone-sensitive lipase (HSL) has a wide tissue distribution with the highest expression found in white adipose tissue (WAT). HSL also has a unique ability to hydrolyze a large panel of substrates including acylglycerols, cholesteryl esters and retinyl esters. HSL is potentially a new drug target for the treatment of obesity and type II diabetes. However, as HSL is not only expressed in adipose t

Popular Abstract in Swedish Prostatacancer är den bland män vanligast förekommande cancerformen i Sverige. Under 2003 diagnostiserades 9882 nya fall. Sjukdomen drabbar framför allt äldre individer; många män är 70 år gamla eller äldre när de får diagnosen. Sjukdomsförloppet kan vara mycket varierande. Hos många är tumörtillväxten långsam, men sjukdomen kan också utvecklas snabbt. Många patienter lConcentrations of prostate-specific antigen (PSA) and human kallikrein 2 (hK2) were investigated in blood samples that had been obtained from men who were diagnosed with prostate cancer (PCa) decades later. The studies were based on a cohort comprising 22,444 men who, in 1974?1986, were early middle aged and represented a non-PCa-screened population. The results clearly demonstrate a very strong c

Abstract in Norwegian Hovudlina i forskinga på lesing og skriving byggjer på tanken om at talt språk på alle vesentlege punkt er primært i høve til skrive språk. Omgrepsapparatet for studiet av språk og lese- og skrivedugleik er også bygd kring denne tanken. Dette er problematisk frå eit vitskapsteoretisk standpunkt sidan tanken om det talte språket sin dominans ikkje er tilstrekkeleg empirisk undMainstream research on reading and writing is based on the assumption, common in modern linguistics, that spoken language is primary to written language in most important respects. Unfortunately, the conceptual framework for the study of language and 'literacy' (encompassing both reading and writing skills) is built around this assumption. This is problematic with regard to the philosophy of scien

BACKGROUND AND OBJECTIVES: Human genetic studies support a key role of interleukin-6 (IL-6) in the pathogenesis of ischemic stroke. Still, there are only limited data from observational studies exploring circulating IL-6 levels as a risk factor for ischemic stroke. Here, we set out to perform a systematic review and meta-analysis of aggregate data on cohort studies to determine the magnitude and s

We briefly review the various machine learning methods and discuss how they can be used in efficient identification and analysis of spectroscopic binary stars. They can be treated as complementary to conventional methods, and we argue that some amount of human oversight is always needed and in fact highly beneficial when employing machine learning. We propose that a general dimensionality reductio

Scientific summary: Amongst other affected countries, Namibia endured seasonal floods in different parts of the country namely, Karas, Kavango, Caprivi, Ohangwena, Omusati, and Oshana regions. However, the study was only conducted on the floods within the Ohangwena region. Major flooding in this region became eminent from 2007, and only rapid appraisal assessments were conducted. As a consequence,

Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort RESEARCH ARTICLE Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort Ashok Sharma1, Xiang Liu2, David Hadley2,3, William Hagopian4, Edwin Liu5, Wei- Min Chen6, Suna Onengut-G

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/55%2006032016_679_55_Sharma_PlosOne_2016.pdf - 2026-05-27

The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl

Thesis Purpose: This study explores the major drivers and barriers to eco-innovation in Scandinavian and Finnish furniture companies, examining the influence of company size and age. The findings benefit stakeholders including businesses, policymakers, professionals, investors, and consumers. Theoretical Perspective: This study’s theoretical framework was developed through an exploration of eco-in

Flooding in oil palm plantations in Southeast Asia is a common problem. The oil palm’s habitable range is restricted to lowland equatorial areas, and the high rainfall and degraded landscapes associated with oil palm cultivation leaves oil palm prone to flooding. Flooding diminishes yields in mature palms, increases mortality in young palms, and disrupts operational processes. This reduces the ec

MiRNA molecules have the ability to regulate hundreds of gene expressions and play a central role in a wide range of biological processes. MiR-7 may be a potential tool and promising target to improve and optimize the growth characteristic and antibody productivity in Chinese Hamster Ovary (CHO) cells which represent the most commonly used mammalian cell line for therapeutic recombinant protein pr

Near-Infrared Spectroscopy (NIRS) has become popular in many research fields for the past two decades. NIRS technology uses near infrared light for measuring changes in the concentration of deoxygenated hemoglobin and oxygenated hemoglobin. Noninvasive near-infrared absorption measurements in tissue have many invaluable applications in the medical field. Today NIRS is a very attractive technique w

Purpose: To investigate whether our case company's entry mode decisions can be understood and explained by existing literature on choice of entry modes and national barriers to entry. Methodogy:A case study has been chosen as the main research design; we investigate our case firm thoroughly. At the same time we study the national markets Starbucks has entered with focus on the national barrier

Påverkar det vort transportval när vi bekymrar oss om klimatet? När vanliga människor oroar sig om klimatförändringen har det betydning för hur dom uppfattar sin transport i vardagen. Klimatbekymringen spelar i denna studie ingen avgörande roll för om folk väljer bil, bus eller cykel. Men ändå påverkas t. ex. synen på olika transportformer och känslan för vad som är ett individuellt ansvar. KlimaCitizens concerned about climate change could represent a potential for changes in everyday travel behaviour in a less carbon intensive way, or even put public pressure on governmental decisions to mitigate climate change emissions from the transport sector. Situated in the context of rural residents’ everyday life in Denmark, this study explores how the role of climate change concerns within resi

Quantum computing has advanced rapidly throughout the past decade, both from a hardware and software point of view. A variety of algorithms have been developed that are suitable for the current generation of quantum devices, which are referred to as noisy intermediate-scale quantum devices. Amongst them is the variational quantum algorithm, a hybrid quantum-classical algorithm that optimizes the p