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We have identified and characterised a cluster of six TRIM-B30.2 genes flanking the chicken BF/ BL region of the B complex. The TRIM-B30.2 proteins are a subgroup of the TRIM protein family containing the tripartite motif ( TRIM), consisting of a RING domain, a B-box and a coiled coil region, and a B30.2-like domain. In humans, a cluster of seven TRIM- B30.2 genes has been characterised within the
The identification of genes underlying quantitative-trait loci (QTL) for complex diseases, such as rheumatoid arthritis, is a challenging and difficult task for the human genome project. Through positional cloning of the Pia4 QTL in rats, we found that a naturally occurring polymorphism of Ncf1 (encoding neutrophil cytosolic factor 1, a component of the NADPH oxidase complex) regulates arthritis s
Ultra-thin magnesium and magnesium-nickel films grown on Mo(110) under ultra-high vacuum (UHV) conditions are hydrogenated at room temperature with atomic H and studied by high-resolution core-level photoelectron spectroscopy (PES). For the Mg-film a layer of hydride is formed at the Mg/Mo interface and a sub-mono layer of hydride is formed at the surface, while an intermediate region remained non
Objectives: The antiinflammatory effect of macrolide antibiotics has been well-established, as has their role in the treatment of certain disorders of chronic airway inflammation. Several studies have suggested that long-term, low-dose macrolides may be efficacious in the treatment of chronic rhinosinusitis; however, these studies have lacked a control group. To date, this effect has not been test
This article deals with an archaeology of Reformation in medieval Denmark. The change from Catholic to Protestant confession, which took place in 1536, ha,,; not been subject to elaborate investigation by archaeologists. The main question is, whether material culture reflects differences in the lifestyle between people possessing a Catholic or Protestant belief The focus is to find out how the dif
Abstract is not available
A simple and effective procedure is described for the determination of the best-fit parameters of a given model of a surface structure by analysis of low energy electron diffraction (LEED) intensities. The procedure involves a nonlinear minimisation of chi(2) for the comparison of experimental and calculated intensities as a function of the parameters of the model structure. The minimisation is ca
Although there is no biblical account of the 'Rest on the Flight into Egypt', the story is well known in the Christian world. In pseudo-Matthew the story has developed into legend form. He tells about the Christ-Child commanding the date palm Mary is resting beneath to bend down so that she can eat the fruit. It is found in literary sources from the twelfth century onwards. 'The Rest on the Flight
OBJECTIVE: To explore the risk factors that have been suggested to be associated with the development of SLE. METHODS: A case-control study was performed and a questionnaire was developed to obtain the data. Consecutive female incident cases diagnosed between 1981 and 1999 in a defined geographical area in southern Sweden were included. Controls, matched for calendar year of birth, were selected r
Tec family protein tyrosine kinases have in their N-terminus two domains, The PH domain is followed by Tec homology (TH) domain, which consists of two motifs, The first pattern, Btk motif, is also present in some Pas GAP molecules, C-terminal half of the TH domain, a proline-rich region, has been shown to bind to SH3 domains, Mutations in Bruton's tyrosine kinase (Btk) belonging to the Tec family
Translocations involving an immunoglobulin (IG) locus are a recurring theme in B cell neoplasia. The rearrangements lead to the joining of an IG gene with a (proto)oncogene, whereby the latter comes under the influence of transcription-stimulating sequences in the constitutively active IG locus resulting in deregulation of the oncogene and neoplastic growth. We present here three cases of B cell n
Phenotypic plasticity may enable organisms to optimize their phenotypes in environments that are heterogeneous over time or space. For example, inducible defenses are favored for prey populations faced with variable predation risk. We studied the impact of brook trout (Salvelinus fontinalis) on the development of defensive morphological characters in larvae of the mayfly, Drunella coloradensis, bo
The aim of this study is to investigate how Swedish learners of English (at different levels of proficiency) master idiomaticity in their target language. I argue that idiomaticity can be related to the storage and use of multi-word expressions that are preferred by native speakers. These multi-word units are referred to as prefabs in the present study. By manually identifying and subsequently cla
The homolytic cleavage of the organometallic Co-C bond in vitamin B-12-dependent enzymes is accelerated by a factor of similar to 10(12) in the protein compared to that of the isolated cofactor in aqueous solution. To understand this much debated effect, we have studied the Co-C bond cleavage in the enzyme glutamate mutase with combined quantum and molecular mechanics methods. We show that the cal
A conscious therapeutic approach was used combining methods in physiotherapy with psychological awareness to re-educate nine transfemoral amputees during 10 months in outdoor environments. All were rehabilitated trauma or tumour cases, mean age 33 years, and had worn their prostheses for more than 18 months. The method aimed at integrating the prosthesis in normal movements and increasing body awa
An investigation of the kinetics of the Heck reaction between 4-iodoanisole and styrene catalysed by {cis-1,3-bis[(di-tert-butylphosphino)methyl]-cyclohexane} palladium (11) iodide (1) has been performed in DMF-d(7) solution. Based on mercury poisoning experiments a heterogeneous palladium catalyst formed from the PCsp3P Pd(II) pre-catalyst is proposed. Saturation behaviour with respect to the ole
