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The objective is to systematically review the literature on economic evaluations of pharmacological treatments of dementia disorders. A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we a

Together with Mauritius, Botswana is often categorized as one of two growth miracles in sub-Saharan Africa. Due to its spectacular long-run economic performance and impressive social development, it has been termed both an economic success story and a developmental state. While there is uniqueness in the Botswana experience, several aspects of the country’s opportunities and challenges are of a mo

The streaming instability is a promising mechanism to drive the formation of planetesimals in protoplanetary disks. To trigger this process, it has been argued that sedimentation of solids onto the mid-plane needs to be efficient, and therefore that a quiescent gaseous environment is required. It is often suggested that dead-zone or disk-wind structure created by non-ideal magnetohydrodynamical (M

Background The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF. Methods and Results We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for HF for the

ARGONAUTE1 (AGO1) binds directly to small regulatory RNA and is a key effector protein of post-transcriptional gene silencing mediated by microRNA (miRNA) and small interfering RNA (siRNA) in Arabidopsis. The formation of an RNA-induced silencing complex (RISC) of AGO1 and small RNA requires the function of the heat shock protein 70/90 chaperone system. Some functions of AGO1 occur in association

This article examines challenges to the classical paradigm of education in Sweden that followed in the wake of state-initiated attempts at school reform in the first decades of the nineteenth century. When the internal disputes of the so-called ‘Genius Committee’ resulted in a failure to overcome the increasing divide between reformers, a prolific opportunity to argue the value of practical subjec

Many studies suggest that increased exposure to urban greenness is associated with better population health. Accessing nature can in some circumstances, however, be difficult, especially for individuals with mobility constraints. Therefore, a growing body of work is investigating the ways to replace the in vivo experience with forms of “virtual” contact, in order to provide these individuals with

This paper presents the case study of a newly constructed 1600 m2 kindergarten building in Oslo, Norway. The building has been designed within the framework of the Norwegian Research Council Project LowEx, which aims at engineering solutions to achieve a seasonal coefficient of performance (SCOP) of 6–10 for heating, a seasonal energy efficiency ratio (SEER) of 80–100 for cooling, and an 80% reduc

Insect migrations are spectacular natural events and resemble a remarkable relocation of biomass between two locations in space. Unlike the well-known migrations of daytime flying butterflies, such as the painted lady (Vanessa cardui) or the monarch butterfly (Danaus plexippus), much less widely known are the migrations of nocturnal moths. These migrations - typically involving billions of moths f

Charophytes play a critical role for the functioning of shallow lake ecosystems. Although growth of charophytes can be limited by many factors, such as temperature, nutrients and light availability, our understanding about concomitant effects of climate warming and other large-scale environmental perturbations, e.g. increases in humic matter content (‘brownification’) is still limited. Here we con

We recently reported that a red meat (beef) diet relative to a casein-based diet increases protein kinase C (PKC) activity in rat colonic mucosa. The purpose of this study was to further elucidate the effects of a high-beef diet on colonic intracellular signal transduction by analyzing steady-state protein levels of different PKC isozymes as well as activities of the three types of sphingomyelinas

The present paper assesses the usage of relational ontologies in the realm of macromarketing made available by consumer culture theorists. Our paper advances this movement by exploring the potential of relational ontologies to propel a more thorough methodological discussion and operationalization of relationality in macromarketing. To fulfill this task, the paper first identifies and discusses fo

Objective: To quantify opioid use in knee and hip osteoarthritis (OA) patients, and to estimate the proportion of opioids in the population attributable to OA patients. Design: Population-based cohort study. Methods: We included 751,579 residents in southern Sweden, aged ≥35 years in 2015. Doctor-diagnosed knee or hip OA between 1998 and 2015 was the exposure. Dispensed weak and strong opioids wer

The essay gives a brief account of Brecht’s years of exile in Denmark, Sweden and Finland. Central to this story were his close relations with a number of cultural figures in the Nordic countries. The essay also discusses the way Brecht’s writing was transformed during his Nordic exile. It focuses on the fact that he wrote some of his best-known plays and developed his famous theory of Verfremdung

Climate change increases the risks of heat stress, especially in urban areas where urban heat islands can develop. This literature review aims to describe how severe heat can occur and be identified in urban indoor environments, and what actions can be taken on the local scale. There is a connection between the outdoor and the indoor climate in buildings without air conditioning, but the pathways

We introduce a Multilevel Monte Carlo method for approximating the transitiondensity for discretely observed multivariate diffusion processes. These areused within a Pseudo-marginal Metropolis-Hastings (PMMH) algorithm to do Bayesianinference on the parameters.The Pedersen representation shows how the transition density can be representedas a conditional expectation, but the corresponding Monte Ca

Examining renovation processes having reduced energy consumption as an explicit goal, this article considers how energy efficiency is made part of renovation processes, focusing on the planning and design phase. Interviews and participant observations of meetings have been conducted. Applying a framework developed in practice theory, we demonstrate the importance of understanding routines, technol