Sökresultat

Introduction: Case–control analyses have shown BARD1 variants to be associated with up to >2-fold increase in risk of breast cancer, and potentially greater risk of triple negative breast cancer. BARD1 is included in several gene sequencing panels currently marketed for the prediction of risk of cancer, however there are no gene-specific guidelines for the classification of BARD1 variants. We pres

Background: Women are less likely to receive oral anticoagulation or ablation for treatment of atrial fibrillation (AF). Identification of sex differences in arrhythmia characteristics and symptoms may lead to a better understanding of potential reasons for these differences. Objectives: To determine sex differences in AF with respect to heart rate, duration, burden, and symptoms in patients under

In the world we live in today, the presence and claims of crisis abound – from climate change, financial and political crisis to depression, livelihoods and personal security crisis. There is a challenge to studying crisis due to the ways in which crisis as a notion, condition and experience refers to and operates at various societal levels. Further, different kinds of crisis can overlap and inter

Phased array antennas are cornerstones in many proposed antenna solutions concerning the next generation of both airborne radar systems and wireless communication systems (5G). Additionally, millimeter wave (mm-wave) frequencies are expected to play an integral role in 5G, and are deemed well-suited for inspecting structural components used in the aerospace industry.This dissertation consists of a

Background: Up to one third of adults have been estimated to have rotator cuff tendon (RCT) tears. Larger RCT tears are associated with poorer scores and function, and are more likely to re-rupture after surgical repairs, hence there is a need for earlier identification and treatment. The aim of this study was to identify biomarkers of RCT tear pathologies to aid accurate identification and monito

BACKGROUND AND OBJECTIVES: Human genetic studies support a key role of interleukin-6 (IL-6) in the pathogenesis of ischemic stroke. Still, there are only limited data from observational studies exploring circulating IL-6 levels as a risk factor for ischemic stroke. Here, we set out to perform a systematic review and meta-analysis of aggregate data on cohort studies to determine the magnitude and s

Elevated molybdenum (Mo) contents in organic-rich sediments are indicative of deposition from an anoxic and sulfide-rich (euxinic) water-column. This can be used for tracing past euxinic conditions in ancient oceans from sedimentary archives. Conventional analytical detection of elevated molybdenum levels is, however, expensive and cannot be directly performed in the field. Here, we show that hand

MiRNA molecules have the ability to regulate hundreds of gene expressions and play a central role in a wide range of biological processes. MiR-7 may be a potential tool and promising target to improve and optimize the growth characteristic and antibody productivity in Chinese Hamster Ovary (CHO) cells which represent the most commonly used mammalian cell line for therapeutic recombinant protein pr

The last years the number of children subjected to compulsory care under the Care of Young Persons Act (LVU) increased substantially with no clear explanation. A person under 20 years can be subjected to compulsory care under the Care of Young Persons Act if he or she has a socially destructive behavior. The purpose of the prerequisite is to make sure that children who in other ways than through s

Den organiserade brottslighetens utveckling är en omstridd fråga. Statistikföringen lider av en definitionsproblematik, där den organiserade brottsligheten innefattar en mångfacetterad kategori av utövare. Den gemensamma nämnaren för den organiserade brottsligheten framstår däremot som mer tydlig; en strävan om ekonomisk vinning. Brottbekämpningen har därför riktat in sig på själva incitamentet tiThe development of organized criminal enforcement is a controversial matter. Partly explained by the compilation of statistics suffers from a definition problem, where organized crime involves a multifaceted category of practitioners. The same does not hold true for organized crime, where the common denominator seems more apparent, being the pursuit of financial gain. Hence, the fight against crim

Behövs kemiska bekämpningsmedel inom jordbruket? I Sverige finns ekologiska jordbruk, detta betyder bland annat att kemiska bekämpningsmedel inte används för att bespruta grödorna inom dessa jordbruk. Ekologiska lantbrukare använder sig istället av biologisk kontroll, vilket betyder att naturliga rovdjur till skadeinsekter introduceras i jordbrukslandskapet för att äta skadeinsekterna. För att unChemical pesticides have long been used to keep crops free from pests, but in modern agriculture biological control is viewed as a viable alternative to pesticides. The concept of biological control is to implement predators that feed upon the pests. It can however be difficult to follow the effects of the biological control in the field, which is why a theoretical mathematical model has been desi

Barnets ställning i det svenska samhället har under de senaste århundradena utvecklats från en obetydlig människa till en individ som spelar en stor roll i människors liv. Denna utveckling är ett exempel på hur mänskliga relationer och sociala processer påverkar hur man ser på olika individer i samhället. Utvecklingen skulle också kunna ses som en bidragande orsak till varför vårdnadstvister har öIn the last centuries, the child´s position in society has evolved from being seen as an insignificant human being to an individual that plays an important role in people’s lives. This development is an example of how social processes and human relations play part in how we see different people in society. The custody disputes in Sweden has increased over the past years. The evolvement of the chil

Abstract Introduction. The Brain is an amazingly complex piece of biological hardware, capable of massive information processing. It relies heavily on the delicate interactions between huge distributed networks to work properly. When these interactions are altered there can be any number of consequences. These carefully tuned networks are largely dependent on the internal interaction of multiple g

Thesis Purpose: This study explores the major drivers and barriers to eco-innovation in Scandinavian and Finnish furniture companies, examining the influence of company size and age. The findings benefit stakeholders including businesses, policymakers, professionals, investors, and consumers. Theoretical Perspective: This study’s theoretical framework was developed through an exploration of eco-in

Flooding in oil palm plantations in Southeast Asia is a common problem. The oil palm’s habitable range is restricted to lowland equatorial areas, and the high rainfall and degraded landscapes associated with oil palm cultivation leaves oil palm prone to flooding. Flooding diminishes yields in mature palms, increases mortality in young palms, and disrupts operational processes. This reduces the ec

Quantum computing has advanced rapidly throughout the past decade, both from a hardware and software point of view. A variety of algorithms have been developed that are suitable for the current generation of quantum devices, which are referred to as noisy intermediate-scale quantum devices. Amongst them is the variational quantum algorithm, a hybrid quantum-classical algorithm that optimizes the p

Popular Abstract in Swedish Hjärt- kärlsjukdomar är den vanligaste dödsorsaken i Sverige. Den bakomliggande orsaken till de allra flesta fall av hjärt- kärlsjukdom är vad som i vardagligt tal kallas åderförkalkning. Den medicinska termen för åderförkalkning är ateroskleros. Ateroskleros är en inflammatorisk sjukdom i artärerna som orsakas av att LDL-partiklar, det så kallade onda kolesterolet, ansThe immune system is a promising target for novel therapies that are aiming at reducing cardiovascular diseases. Autoimmune responses against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by immunosuppressive regulatory T cells (Tregs). Immunizations of hypercholesterolemic mice with oxidized L

The competition in the banking industry has during the last decades been intensified resulting in smaller interest margins. As a consequence, the resources spent on each credit customer have had to be decreased, resulting in less interaction and a perceived limited access to valuable information. This has especially been the case in the banks´credit management of small firms. Earlier research app

Near-Infrared Spectroscopy (NIRS) has become popular in many research fields for the past two decades. NIRS technology uses near infrared light for measuring changes in the concentration of deoxygenated hemoglobin and oxygenated hemoglobin. Noninvasive near-infrared absorption measurements in tissue have many invaluable applications in the medical field. Today NIRS is a very attractive technique w

På senare år har relationen mellan arbetsminne och tal- och språkförmåga studerats inom en rad områden; normalspråkiga barn och vuxna, barn med språkstöming, barn med dyslexi samt barn och vuxna med hörselskador. För barn och vuxna med hörselskador har arbetsminnet visat sig ha stor betydelse för olika aspekter av språkförmågan, t ex förmågan att lära in nya ord. För vuxna med hörselskador har man