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Obesity and Surgical Treatment - A Cost-Effectiveness Assessment for Sweden

The rising trend in the prevalence of obesity has become a major public health concern in many countries during the past decades, partly because being obese is associated with comorbidities and death. The cost of treatment for obesity related diseases has become a heavy burden on the national health care budget in many countries. The treatment options for obesity are mainly weight management thera

The Effect of Musculoskeletal Pain on Sexual Function in Middle-aged and Elderly European Men: Results from the European Male Ageing Study.

OBJECTIVE: To determine whether musculoskeletal pain was associated with impaired sexual function in a population sample of middle-aged and older men. METHODS: The European Male Ageing Study (EMAS), a multicenter population-based study of men aged 40-79 years, was used to investigate this hypothesis. A questionnaire asked about the presence and duration of musculoskeletal pain, allowing subjects t

Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth.

Objective: Cord blood islet autoantibodies in children born to mothers with type 1 diabetes may be associated with a reduced risk of islet autoimmunity and diabetes. The aim of this study was to investigate in children with type 1 diabetes but born to non-diabetic mothers whether islet autoantibodies at birth affected their presence at diagnosis. Patients and methods: Serum samples at birth and at

Early Complementopathy After Multiple Injuries in Humans.

ABSTRACT: After severe tissue injury, innate immunity mounts a robust systemic inflammatory response. However, little is known about the immediate impact of multiple trauma on early complement function in humans. In the present study we hypothesized that multiple trauma results in immediate activation, consumption and dysfunction of the complement cascade and that the resulting severe "complemento

Nurses' personalities, nursing-related qualities and work satisfaction: a 10-year perspective

The personalities and qualities of nursing personnel are considered to be of great importance for their interactions and nursing relationships with patients and may also influence work satisfaction. The aim of the study was to explore the extent to which different personal qualities and personality factors, with a possible effect on motivation, professional conduct and coping with stress and anxie

Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets.

Background aims Human mesenchymal stromal cells (MSC) are promising candidates for cell therapy because of their intriguing properties (high proliferation and differentiation capacity, microenvironmental function and immune modulation). However, MSC are heterogeneous and a better understanding of the heterogeneity of the cells that form the MSC cultures is critical. Methods Human MSC were generate

Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours.

Amplification of chromosomal region 11q13, containing the cell cycle regulatory gene CCND1, is frequently found in breast cancer and other malignancies. It is associated with the favourable oestrogen receptor (ER)-positive breast tumour phenotype, but also with poor prognosis and treatment failure. 11q13 spans almost 14 Mb and contains more than 200 genes and is affected by various patterns of cop

Gas phase molecular relaxation probed by synchrotron radiation experiments

This thesis presents experimental studies of gas phase molecular relaxation after excitation with synchrotron photons in the 15-35 eV and in the 70-350 eV regions. In the 15-35 eV region, molecular relaxation by neutral dissociation processes and non Franck-Condon effects in N2 and O2 molecules have been studied by means of dispersed fluorescence and photoelectron spectroscopy experimental tec

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

FYN is a non-receptor tyrosine kinase belonging to the SRC family of kinases, which are frequently over-expressed in human cancers, and play key roles in cancer biology. SRC has long been recognized as an important oncogene, but little attention has been given to its other family members. In this report, we have studied the role of FYN in FLT3 signaling in respect to acute myeloid leukemia (AML).

A statistical analysis of data from the production line at the Munksund paper mill

A multivariate statistical analysis of paper strength and production process data from the SCA Munksund paper mill is presented. The analysis is divided into five parts: (i) paper quality variables, (ii) process variables from the paper machine, (iii) process variables from digester and refiner, (iv) a combination of all process variables, and (v) a further analysis of the z-strength. Analysing

The impact of social capital on changes in smoking behaviour: a longitudinal cohort study.

Background: Smoking prevalence across high-income countries such as the United Kingdom has significantly decreased over the past few decades; this decrease, however, has not occurred uniformly across social strata. The highest concentrations of smokers are currently found in lower-income groups. Lack of access to material resources and differing social norms have been cited as possible causes of t

Ascertainment and diagnostic accuracy for hematopoietic lymphoproliferative malignancies in Sweden 1964-2003.

Population-based cancer registries are widely used to provide key information about cancer incidence, survival, determinants of progression and clues about pathogenesis. To substantially expand the limited data on diagnostic accuracy and completeness for lym-phoproliferative (LP) tumors in such databases, we conducted a retrospective investigation of close to 1,000 cases diagnosed during 4 decades

Adherence to treatment guidelines for patients with chest pain varies in a nurse-led prehospital ambulance system.

INTRODUCTION: Studies have shown that adherence to prehospital treatment guidelines, for patients with non-traumatic chest pain is incomplete and that there is a gender difference in treatment provided. PURPOSE: The aim of this study was to examine adherence to guidelines in a nurse-led ambulance system in southern Sweden. METHOD: Retrospective cohort study, including 862 medical records was rev

Dairy products and its association with incidence of cardiovascular disease: the Malmö diet and cancer cohort.

It is unclear whether specific dairy products are associated with risk of cardiovascular disease (CVD). The aim of this project was therefore to examine the association between intake of milk, cheese, cream and butter, and incidence of CVD in the Swedish Malmö Diet and Cancer cohort. Milk was separated into fermented (yoghurt and cultured sour milk) versus non-fermented milk, and low-fat versus hi

Circadian variation in concentration of anti-Mullerian hormone in regularly menstruating females: relation to age, gonadotrophin and sex steroid levels.

BACKGROUND Anti-Müllerian hormone (AMH) is a promising marker of ovarian reserve. The aim of the study is to assess the circadian variation in AMH, and to evaluate its clinical relevance and biological aspects as an effect of age and other endocrine mechanisms involved in the regulation of AMH secretion. METHODS Nineteen healthy non-smoking, regularly menstruating female volunteers with body mass

Planens miljöpåverkan – En studie av bedömningsmetoder för kommunala detaljplaner

För varje detaljplan som en svensk kommun behandlar skall en påverkansbedömning göras där planens miljöpåverkan undersöks. Om påverkan utifrån bedömningen antas vara betydande skall detta utredas vidare. Kommunerna får dock själva avgöra hur bedömningen genomförs, och kontrollen av bedömningen är svag. Studien undersöker vad detta lett till genom att granska vilka metoder som används idag, och vilThe environmental impact of each new detailed development plan must in some way be assessed in Sweden. If the impact is deemed be significant, this must be further investigated. However, the municipalities can determine themselves how the assessment is done, and the monitoring of the assessment is weak. The study examines the consequences of this by screening what methods are used for the assessme

The Nordic IPO Puzzle

Purpose: To evaluate the Nordic IPO markets from an academic perspective taken from an investor's point view. Methodology: Quantitative research Theoretical perspective: Majority of previous research suggest that in the long run newly listed companies underperform comparable companies on the market when comparing changes in stock prices. However, there have been some studies that have f

De kommersiella volontärresebyråerna : En kvalitativ studie om svenska volontärresebyråers perspektiv på volonturism

International work aid is a form of social work that historically has been conducted by non-profit organizations. When the commercial volunteer agencies entered the market they did so with a well-known product but with a different organizational form. The for-profit social enterprise does not only aim to create social value but also financial value. The commercial volunteer travels, called volunto

Marshallplanen - En motivanalys av USA:s bakomliggande motiv till beslutet av Marshallplanen

I denna undersökning har vi tagit på oss uppgiften att undersöka de bakomliggande motiven till beslutet av Marshallplanen. I denna granskning använde vi också hjälp av två teoretiska perspektiv realismen och konstruktivismen för en mer djupare insikt. Efter andra världskrigets slut kunde ingen förutse hur lång tid det skulle ta för Europa att återuppbyggas till sitt tidigare skick. USA såg då dett

Blockkedjeteknologins relevans för svensk hälso- och sjukvård: En omfattande utvärdering av hur teknologins möjligheter och vårdens framtidsvision överlappar

Titel: Blockkedjeteknologins relevans för svensk hälso- och sjukvård: En omfattande utvärdering av hur teknologins möjligheter och vårdens framtidsvision överlappar Författare: Svante Nyman och Mattias Wendler Handledare: Carl-Johan Asplund, Avdelningen för Produktionsekonomi, LTH & Sarah Lidé, Branschspecialist Hälso- och sjukvård, PwC Sverige Bakgrund: Idag är vården i Sverige i många Title: The Importance of Blockchain Technology for Swedish Healthcare: An Evaluation of the Opportunities of Blockchain and the Future of Healthcare Authors: Svante Nyman and Mattias Wendler Supervisors: Carl-Johan Asplund, Faculty of Engineering, Lund University & Sarah Lidé, Healthcare Industry Expert, PwC Sweden Background: Today, healthcare in Sweden is, in many cases, costly, but th