Sökresultat

Objective: Sweetened beverage intake is associated with increased risk of type 2 diabetes, but its association with autoimmune diabetes is unclear. We aimed to investigate sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA); autoimmune diabetes with features of type 2 diabetes. Design/methods: Data from a Swedish population-based study was used, including incident cas

Popular Abstract in Swedish Människor har i alla tider försökt reparera och ersätta skadade vävnader i kroppen. Förr användes naturliga material som t. ex. bomull, silke, tagel och läder. Under 1900-talet har flera syntetiska (konstgjorda) material utvecklats, framförallt olika typer av polymerer (plaster), för användning som ersättning av skadade kroppsvävnader. Beroende på vilken typ av vävnad sThe aim of this work was to achieve surface modification of two biomedical polyurethanes and one poly(urethane urea) through the addition of small amounts of amphiphilic copolymers in solution. The matrix polymers used were the poly(ether urethane)s Pellethane 2363-80AE (P80) and 2363-75D (P75) and a poly(ether urethane urea) similar to Biomer (PUUR). The amphiphilic additives consisted of segment

Background: Mobility is important for the cognitive and psychosocial development of children. Almost one third of children with cerebral palsy (CP) are non-ambulant. Wheelchairs can provide independent mobility, allowing them to explore their environment. Independent mobility is vital for activity and participation and reduces the dependence on caregivers. The purpose of this study was to describe

Popular Abstract in Swedish Det svenska utbildningsväsendet styrs av nationella styrdokument som skollag, läroplaner och kursplaner. Det demokratiska uppdraget är en central fråga i dessa dokument. Avhandlingens syfte är att undersöka hur pedagogerna hanterar detta demokratiuppdrag och hur de påverkas av sociala krafter på olika nivåer. Demokratibegreppet är öppet för olika tolkningar. Inom utbiThe Swedish education system is governed by national steering documents, like the Education Act, curriculi and syllabuses. The democratic assignment is a central issue in these documents. The thesis aims to investigate how teachers handle this democratic assignment and how they are influenced by forces on different social levels. The concept of democracy is open to many interpretations. Democrac

Popular Abstract in Swedish Ger en ökad fysisk aktivitet bland växande barn bättre skelett- och muskelutveckling och påverkar det i så fall frakturrisken? Benskörhet och låg benmassa medför en ökad risk för frakturer. Låg fysisk aktivitet är också en riskfaktor. En ökad frakturförekomst är i dag ett växande samhällsproblem, och med dessutom en åldrande population samt en generellt mindre fysiskt Osteoporosis and related fractures are a global health problem. Physical activity, especially during growth, has been suggested as a strategy to improve musculoskeletal health in the population. Previous prospective pediatric exercise intervention studies, however, are short-term, mostly covering less than one year and use bone traits as surrogate endpoints for fractures. The Pediatric Osteoporosi

Background There are limited data on survival patterns among patients with monoclonal gammopathy of undetermined significance. Design and Methods We compared the survival of 4,259 patients with monoclonal gammopathy of undetermined significance, collected from hematology outpatient units in Sweden, with the survival of the general population by computing relative survival ratios. We also compared

The current prevalence of persons amputated at transmetatarsal level or higher in Sweden can be estimated to be between 5000 and 5500 persons (approx. 0.06 % of the population). The majority of these are patients with vascular disease (≈ 80%). In Sweden between 1000 and1100 new amputees can be expect every year. Less than 5% of all amputations will be related to causes other than vascular disease.

Popular Abstract in Swedish Det finns ett flertal hormoner som bildas i mag-tarmkanalen och som sedan frisätts till blodet i samband med måltidsintag. Runtom i kroppen finns det sedan målceller, så kallade receptorer, som stimuleras av hormonerna till att påverka olika processer i kroppen. De hormoner från mag-tarmkanalen som vi har studerat är de så kallade inkretinhormonerna, glukagon-lik peptidSeveral different hormones are released from the intestine following a meal. In this thesis we have focused on the so called incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). An important function of the incretin hormones is potentiation of insulin release from pancreatic beta-cells following a meal. This property has attracted a lot of inte

An acoustic trap with miniaturized integrated transducers (MITs) for applications in non-contact trapping of cells or particles in a microfluidic channel was characterized by measuring the temperature increase and trapping strength. The fluid temperature was measured by the fluorescent response of Rhodamine B in the microchannel. The trapping strength was measured by the area of a trapped particle

Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time

Popular Abstract in Swedish Frågorna som partikelfysiker ställer är samma frågorna som folk har ställt under hela mänsklighetens tid på jorden, nämligen: Var kommer vi från? Vad är det som bygger upp det universum som vi ser? Hur håller allting ihop? Fysiker, historiens stora tänkare och hobbyfilosofen i pubben har alla funderat över de här frågorna (vissa mer än andra). Partikelfysiker försöker hAn introduction into the theory and experimental background of particle physics and the ATLAS detector is given. The transition radiation tracker (TRT) which is vital to the particle tracking and identification is then described giving particular creedence to the calibration. The automation of this calibration is explained. The second half of this thesis and the central part dwells on the analyses

The Garden Warbler is a classic subject for the study of Palaearctic-African bird migration strategies. Most studies have considered the situation close to the breeding areas, while the African and especially the sub-Saharan part of the species' migration have received comparatively little attention. Here we use autumn and spring ringing data from Nigeria and The Gambia to study the movements and

Knowledge concerning the molecular mechanisms governing the influence of non-coding RNAs on protein production has emerged rapidly during the past decade. Today, two main research areas can be identified, one oriented toward the use of artificially introduced siRNAs for manipulation of gene expression, and the other one focused on the function of endogenous miRNAs. In both cases, the active molecu

Purpose. To investigate if testicular cancer survivors (TCSs) have a higher incidence of work loss compared with the population, accounting for stage, treatment and relapse.Material and methods. A cohort of 2146 Swedish TCSs diagnosed 1995-2007 (seminoma n = 926, non-seminoma n = 1220) was identified in the SWENOTECA (Swedish-Norwegian Testicular Cancer Group) register, and matched 1:4 to populati

Background: In workplace health promotion, all potential resources needs to be taken into consideration, not only factors relating to the absence of injury and the physical health of the workers, but also psychological aspects. A dynamic balance between the resources of the individual employees and the demands of work is an important prerequisite. In the home care services, there is a noticeable t

Caveolae are membrane organelles that play roles in glucose and lipid metabolism and in vascular function. Formation of caveolae requires caveolins and cavins. The make-up of caveolae and their density is considered to reflect cell-specific transcriptional control mechanisms for caveolins and cavins, but knowledge regarding regulation of caveolae genes is incomplete. Myocardin (MYOCD) and its rela

Mammographic density reflects the composition of the breast tissue and can be measured by different methods. Mammography has a lower sensitivity in women with dense breasts, and women with dense breasts have a higher incidence of breast cancer than do women with non–dense breasts. Furthermore, there has been an increased interest in improving the measurement of mammographic density. The aim of thi

Background: Patients with possible radiation induced cancer could be used to study if the rate of tumour cell proliferation is related to latency time. Such a finding could help researcher to find time periods when other initiating risk factors operate. Methods: Seventeen women with breast cancer, with a prior history of radiation treatment towards the parts or the whole breast, exclusive of the p

Popular Abstract in Swedish För att en organism ska fungera är det nödvändigt att alla de celler som bygger upp organismen kommunicerar med varandra. Denna kommunikation sker genom att speciella proteiner på cellens yta, s.k. receptorer, tar emot signaler från andra celler. G-proteinkopplade receptorer (GPCR) är den vanligaste typen av receptorer. Då en signalmolekyl binder till en GPCR ändrar deIn all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. The total number of GPCRs is estimated to be around 800 where

The pineal organ is the only differentiated photoreceptor organ present in embryos and early larvae of the Atlantic halibut (Hippoglossus hippoglossus). We investigated the molecular identity of opsins in the pineal organ, and their expression during different life stages. Using RT-PCR we identified two 681-bp gene sequences, named HPO1 and HPO4, in cDNA from adult pineal and whole embryos. The pr