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Global reconstructions, inclusive of environments and ecosystems, and biodiversity counts for the Devonian Period are often done so at the expense of high latitude regions given a historical lack of data presented from these areas. This has bearing on the recognition of biocrises (events marked by extinctions and faunal turnovers) at high latitudes as well as their controls and potential correlati

Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)

Background: We aimed to investigate if early life marine n-3 fatty acids and fish intake, and fatty acid desaturase (FADS) genetic variants, were associated with later risk of celiac disease (CeD).Methods: Among 85,244 children in the prospective Norwegian Mother, Father, and Child Cohort Study, fish and marine fatty acid intakes were estimated from questionnaires to mothers during pregnancy, and

Populärvetenskaplig sammanfattning:Elfordon uppfattas ofta som en modern uppfinning, men elektriskt drivna fordon har funnits sedan slutet av artonhundratalet. De första helelektriska personbilarna, bussarna och lastbilarna utvecklades redan innan förbränningsmotorn slog igenom.För att förstå varför elektriska störningar spelar en så viktig roll i dagens elfordon kan man börja med en enkel bild. TThe rapid electrification of heavy-duty vehicles has introduced traction voltage systems (TVS) with electrical scale and complexity not previously seen in on-road applications. Multiple power electronic subsystems interact through long cables and frequency-dependent impedances, making conducted electromagnetic interference (EMI) a system-level phenomenon. Differential-mode (DM) and common-mode (CM

Hallundakomplexet, Botkyrka 13:1 och 69:1, delundersöktes mellan åren 1969–71. (I fortsätt-ningen kommer de båda fornlämningarna att kallas för Hallunda 13 respektive Hallunda 69). Komplexet är än idag, drygt 50 år efteråt, en av Mälardalens fyndrikaste boplats-, verkstads- och gravkomplex från bronsåldern. Platsen ligger strax söder om Mälaren och de mest uppmärksammade lämningarna och fynden på

Post-quantum cryptography increases the computational and data-movement demands placed on embedded processors. Many standardized and candidate schemes rely heavily on Keccak, SHA-3, and SHAKE operations, where the 1600-bit Keccak state is repeatedly updated and may become a bottleneck when accelerated through software-hardware interaction. This thesis presents a direct memory access (DMA)-enhanced

Modern society depends on dams for renewable hydropower, water supply, and flood control. As climate change increases the frequency of extreme rainfall and flood events, and as the demand for renewable energy sources continues to grow, ensuring the safety of these critical structures becomes more urgent than ever. One of the most serious hidden threats in embankment dams is internal erosion – a sl

Background. National registries that capture patients with chronic kidney disease (CKD) across all stages are scarce. We present here the Swedish Renal Registry (SRR), a nationwide prospective register covering the whole spectrum of CKD. Methods. Created in 1991, SRR enrolls CKD patients referred to adult nephrologist care (non-dialysis CKD [ND-CKD], kidney transplantation, maintenance dialysis),

Background: Gut dysbiosis and gut-brain-axis involvement in people with Parkinson's disease (PwP) support the use of gut-microbiota-modulating interventions. Probiotics may help manage constipation in PwP; however, mechanisms underpinning additional beneficial properties are unknown. Objective: The aim was evaluating the effects of a probiotic (Lacticaseibacillus rhamnosus, Lactobacillus acidophil

Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr

Excited states in the proton drip line nucleus 61Ga were populated via the fusion-evaporation reaction 24Mg(40Ca,p2n)61Ga. The experimental setup at Argonne National Laboratory comprised a novel combination of the Gammasphere array with two CD-shaped double-sided Si-strip detectors inside the Microball CsI(Tl) charged-particle detection array, as well as the Neutron-Shell liquid scintillators and

Introduction: Food systems strongly influence both human and planetary health. Unhealthy diets aremajor risk factors for chronic disease and mortality, while food production contributes substantially togreenhouse gas emissions (GHGE), and other negative environmental impacts. Adopting moresustainable dietary patterns, such as the EAT-Lancet diet, has been proposed as part of the solution, butuncer

Course leaders in rehabilitation healthcare professionals’ higher education face challenges stemming from multi-disciplinarity and the co-existence of different stakeholders. So far, the literature mainly attributed to course leaders’ managerial tasks, neglecting other fundamental transversal skills. Students represent an essential source of information for understanding the expected characteristi

Airborne particle emissions from road vehicles represent a significant concern for urban air quality. Among the key contributors to non-exhaust emissions (NEE) are vehicle disc brakes, which have recently been recognized as equally important as exhaust emissions. In disc brake systems, the brake pads are pressed against the rotating disc to decelerate the vehicle. This contact causes wear on the d

Background: Chronic obstructive pulmonary disease, COPD, is an increasing cause of morbidity and mortality worldwide, and an imbalance between proteases and antiproteases has been implicated to play a role in COPD pathogenesis. Matrix metalloproteinases (MMP) are important proteases that along with their inhibitors, tissue inhibitors of metalloproteinases (TIMP), affect homeostasis of elastin and

Background Our aim was to evaluate if increased survival and new ventilation strategies were accompanied by a changed incidence of bronchopulmonary dysplasia (BPD) in Sweden over a decade. Methods Data from two Swedish population-based studies of live-born infants with gestational age (GA) 22–26 weeks, born during 2004–2007 (n=702) and 2014–2016 (n=885), were compared for survival, any BPD, modera

Breast cancer is the most common type of cancer in women worldwide. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the oestrogen receptor, progesterone receptor, and amplification of HER2. This subtype is the most aggressive subtype and a heterogeneous subgroup of breast cancer, making up around 10-15% of the cases, often affecting younger patients

The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for historical, geographical, and secular trends, but until now not linked to health outcomes in the total population, e.g. for cardiovascular disease (CVD) or mortality during follow-up of birth cohorts. We used linkage analysis based on national registers in Swed

Aims/Hypothesis: To test the usefulness of the new WHO criteria for clinical staging of diabetes in the characterization of 1977 diabetic patients. Methods: The following clinical stages were used: patients on diet and/or oral antidiabetic agents 2 years after diagnosis were considered as non-insulin requiring (NIR; n = 711) and patients who required insulin therapy after 1 year as insulin requiri