Sökresultat

Popular Abstract in Swedish Proteiners interaktioner med andra proteiner, med polymerer och med ytor har stor praktisk betydelse inom bland annat proteinrening, läkemedelsformulering och livsmedelsteknologi. Målet med detta arbete är att öka förståelsen för växelverkan mellan proteiner, mellan proteiner och polymerer samt mellan proteiner och ytor, särskilt beträffande de elektrostatiska krafternaInteractions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these syste

Popular Abstract in Swedish Prostanoider, en samlingsbeteckning för prostaglandiner och tromboxaner, tillverkas av de flesta av kroppens olika celltyper och fungerar som en slags hormoner i många olika organsystem i människor och djur. Prostanoiderna bildas alla från prostaglandin H2 som i sin tur tillverkas av enzymet cyklooxygenas (COX) från fettsyran arachidonsyra. Prostanoiderna är alltså fettProstanoids are ubiquitously distributed lipid signaling molecules derived from arachidonic acid, that exhibit numerous and diverse biological effects in a variety of physiological and pathophysiological conditions. The cell surface receptors for the prostanoids belong to the family of G protein-coupled receptors. In this thesis, the author describes the cloning and structural characterization of

This thesis addresses challenges in increasing the robustness of cloud-deployed applications and services to unexpected events and dynamic workloads. Without precautions, hardware failures and unpredictable large traffic variations can quickly degrade the performance of an application due to mismatch between provisioned resources and capacity needs. Similarly, disasters, such as power outages and

Popular Abstract in Swedish En viktig fråga inom modern astrofysik är hur galaxer bildas och utvecklas. Under de senaste decennierna har flera teorier för hur detta sker lagts fram, vilket har lett till att de flesta astronomer idag tror på en modell i vilken större galaxer, så som vår egen Vintergata, bildas genom sammanslagning av mindre galaxer. Trots att modellen rönt stor framgång återstThis thesis presents results from two projects using photometric observations to investigate stellar populations in Local Group galaxies. In the first project, Strömgren photometry is used to study stellar populations in dwarf spheroidal galaxies. It is demonstrated that the Strömgren c1 and m1 colour indices can be efficiently used to identify RGB members in dwarf spheroidal galaxies, and d

Popular Abstract in Swedish Hjärnskador som uppstår till följd av otillräckligt blodflöde (ischemi) drabbar årligen ett stort antal människor i Sverige och leder antingen till död eller invaliditet och åsamkar stort lidande för den drabbade och dennes anhöriga. Den vanligaste orsaken till hjärnischemi är stroke (slaganfall), som beror på en propp i ett blodkärl eller en hjärnblödning, till en begrBrain ischemia is a major cause of death and morbidity in the industrialized countries. It is mainly caused by stroke, but may also be the consequence of successful cardiopulmonary resuscitation in victims of cardiac arrest, known as transient global ischemia. Although extensive effort in the field of brain research using experimental rodent models, no neuroprotective treatments are at present ava

Popular Abstract in Swedish Forskning om stamceller har fått mycket uppmärksamhet de senaste åren. Mycket av intresset avspeglar möjligheten att använda denna typ av celler som en terapi för att bota olika sjukdomar. En stam cell från hjärnan är en cell som har förmåga att dela sig symmetriskt, varvid två kopior bildas eller asymmetriskt, vilket ger upphov till en ny stam cell samt en progenitorceIn the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). Long-term growth factor-expanded

Popular Abstract in Swedish Tunna skikt av olika material har en framträdande roll inom både vetenskap och teknik idag. Det bakomliggande intresset för denna typ av ytbeläggningar är främst möjligheten att kombinera egenskaper hos de tunna filmerna med övriga egenskaper från det underliggande materialet för att därigenom erhålla förbättrade kemiska, mekaniska eller elektriska egenskaper. Därutöver

Popular Abstract in Swedish Den kontinent Skandinavien idag tillhör kallas Eurasia, men den kontinent vi ser idag har inte alltid funnits. Kontinenterna var inte bara sammanfogade på andra sätt, de har också rört sig över jordens yta (de långsamma med samma hastighet som naglar växer!), i platt-tektoniska processer. Innan uppkomsten av Eurasia har Skandinavien i omgångar tillhört andra konstellatiIn an attempt to reconstruct the pre-Caledonian cratonic margin of Fennoscandia, U-Pb geochronological and geochemical investigations have been performed on allochthonous orthogneisses in the northern Swedish Caledonides. The crystalline basement of the nappes have also been examined to further constrain the continuation of various chronologically defined orogenic belts. To constrain the global pa

Popular Abstract in Swedish Avhandlingen innehåller fyra artiklar som berör olika aspekter av offentlig omfördelning i välfärdsstaten. Avhandlingen syftar till att ge kunskap om konsekvenser av, motiv för och mätande av och denna omfördelning. Den första artikeln ställer frågan: Hög hög skatteomfördelning från arbetande till icke arbetande kan motiveras av grundantagandet att naturresurser är gemThis thesis is an attempt to generate knowledge about the justification, measurement and consequences of public redistribution. The first paper poses the following question: How much redistribution from working to non-working can be justified by arguing that external resources are owned jointly by all, or that ownership should ideally be divided equally? This question is analyzed using bargaining

Background: In spite of the World Health Organization's recommendations to maintain caesarean delivery (CD) between 5% and 15% of total births, the rates of CD continue to rise in countries with routine access to medical services. As in Italy CD rate reached 38% in 2008, the highest at EU level, we evaluated socioeconomic and clinical correlates of "elective" and "non programmed" CD in the Country

Background: Alzheimer’s disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the risk allele APOE ε4. The spread of tau pathology is related to atrophy and cognitive decline, but little data exist on the effects of APOE ε4 on tau. The objective of this prelim

Background: Traumatic brain injury (TBI) is a major cause of disabilities and mortality worldwide, with higher prevalence in offender populations than in the general population. Previous research has strongly advocated increased awareness of TBI in offender populations. The aim of this study was to explore the prevalence and characteristics of TBI, and to investigate associations and interactions

Context: Breathlessness is a cardinal symptom in cardiorespiratory disease and consists of multiple dimensions that can be measured using the instruments Dyspnea-12 (D12) and the Multidimensional Dyspnea Profile (MDP). Objectives: The objective of the study is to determine the minimal clinically important differences (MCIDs) of all D12 and MDP summary and subdomain scores as well as the instrument

The EU Trade Secrets Directive (‘the Directive’) has standardized the national laws in EU member states for the protection of trade secrets. For the first time, a harmonised definition of what constitutes a ‘trade secret’ is established as well as common measures aimed at preventing the misappropriating of trade secrets and rules for procedures and sanctions.The adoption of the Directive reflects

Objectives. To evaluate beneficial effects of postmenopausal hormone replacement therapy (HRT) on endothelial function, measured as intraplatelet cyclic guanosine monophosphate (cGMP, mediator of nitric oxide), cyclic adenosine monophosphate (cAMP, mediator of prostacyclin) and plasma endothelin-1 (ET-1), and on monocyte activation, measured as plasma neopterin. Design. Part 1: double-blind random

OBJECTIVE: To construct an artificial neural network (ANN) model to predict survival after liver resection for colorectal cancer (CRC) metastases. BACKGROUND: CRC liver metastases are fatal if untreated and resection can possibly be curative. Predictive models stratify patients into risk categories to predict prognosis and select those who can benefit from aggressive multidisciplinary treatment an

Background: The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA). In RA, however, autoantibodies such as ACPA, rheumatoid factor (RF), and anti-carbamylated protein antibodies (anti-CarP) often occur together, and it is thus unclear whether smoking is specifically associated with some autoantibodie

Objective There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence of CHD later in life among women in a large, pan-European cohort study. Methods Data were used from European Prospective Investigat

Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare report

Background/Objectives:Dietary addition of either conjugated linoleic acid (CLA) or n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) has been shown to alter adiposity and circulating lipids, risk markers of cardiovascular diseases. However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA. Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secr