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Discussion on social media and their contribution to democratisation is dominated by scholarship on the use of social media in mobilizing and coordinating grassroots opposition in contentious movements (e.g., the Arab Spring). Such approach, however, fails to recognize the power dynamics underlying everyday uses of social media. To fill this gap, this article provides one of the first studies on t
This study is motivated by two research questions: (1) How is an organizational control system established and maintained in product and process innovation? (2) How are innovation processes facilitated or hindered as a result of the interplay between forms of control and autonomy? The thesis investigates these questions by means of an in-depth longitudinal case study involving 15 innovation projec
The chi(b)(np) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider at root s=7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb(-1), these states are reconstructed through their radiative decays to Y(1S,2S) with Y ->mu(+)mu(-). In addition to the mass peaks corresponding to the decay modes chi(b)(1P,
BACKGROUND AND OBJECTIVE: Severe idiopathic pulmonary fibrosis is associated with an increased risk of cardiovascular disease and gastro-oesophageal reflux, which may influence prognosis. We evaluated associations between cardiovascular and antacid medications, and mortality, in oxygen-dependent pulmonary fibrosis (PF) of unknown cause.METHODS: Prospective population-based study of adults starting
A novel approach in molecular design is presented, where in vivo formed complementarity determining regions (CDR) from antibody genes were shuffled into a specific framework region. A synthetic gene library of soluble VH-fragments was created and the complexity of the library was determined by sequencing. The synthetic genes were diverse and contained random combinations of CDR from different germ
PURPOSE: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovar
Public diplomacy is the communication of an international actor’s policies to citizens of foreign countries. These citizens might include civil society representatives, nongovernmental organisations, multinationals, journalists and media institutions, specialists across different sectors of industry, politics and culture, and members of the general public. They are typically engaged by actors like
Analysis of human cartilage extracts by radioimmunoassay showed that the noncollagenous 148-kd cartilage matrix protein was present in extracts of tracheal cartilage but was undetectable in normal or arthritic joint cartilage, corroborating previous results with bovine cartilage samples. Concentrations of the protein in the circulation, as studied by radioimmunoassay, were greatly elevated in pati
The purpose of dynamic asset allocation (DAA) is to overcome the challenge that changing market conditions present to traditional strategic asset allocation by adjusting portfolio weights to take advantage of favorable conditions and reduce potential drawdowns. This article proposes a new approach to DAA that is based on detection of change points without fitting a model with a fixed number of reg
This paper discusses the strategy of the Czech economic policy as regards the current enlargement process of the European Economic and Monetary Union (EMU). The authors discuss the validity of the Maastricht criteria for the new European Union (EU) member countries, as well as the risks and puzzles of both real and nominal convergence processes. The paper shows that current fiscal policy is the ma
BACKGROUND AND PURPOSE: The purpose of this study was to obtain a deeper understanding of the process of motivation for change in patients with prolonged musculoskeletal disorders and to identify factors that might influence change resulting in increased independence.METHOD: A qualitative two-year follow-up study. Data collection and analysis were performed according to the qualitative case study
We estimated the number of different human genes by relating the patterns of spontaneous mutation at the population and individual level. A geometric distribution model of mutation was used in which the average rates of nucleotide replacement (P) and mutation at a locus (p), obtained by experiment, were used to determine the estimate of the physical size of the coding genome (n) in man. The probab
Aim: This study evaluated the musculoskeletal effects of increased physical activity on children, starting at six to nine years of age. Methods: In one school we increased the physical education of 72 girls and 100 boys to 200 minutes per week over seven years. In three other schools, 45 girls and 47 boys continued to receive 60 minutes per week. We measured areal bone mineral density (aBMD) with
For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system’s primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued b
Creating bimodal grain size distribution in crystalline materials is an effective strategy to improve structural efficiency. Present investigation demonstrates that further control over topology through the formation of bimodal 'harmonic' structure simultaneously increases average values of strength and ductility, reduces the variation of corresponding properties, and thwarts the localization of p
