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The slopes of the Tågerup promontory in western Scania contain one of the largest known Mesolithic settlements that has ever been excavated in Scandinavia. The Tågerup site displays a unique combination of huts and houses, graves and wooden implements, flints and bones which constitute a 1500-year-long Mesolithic occupation sequence, dated 6500–5000 cal BC. During that time, there were gradual but
Background: We have recently analyzed the profile of T-cell subtypes based on chemokine receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients compared to healthy controls (HC). Here, we compared the levels of the respective chemokines in blood plasma of ueRA patients with those of HC. We also studied the association of chemokine levels with the proportions of circu
We look at multigrid methods for unsteady viscous compressible flows. We specifically target smoothers that can be used in parallel and without computation of a Jacobian, which are particlarly attractive candidates in the context of Discontinuous Galerkin discretizations. In CFD, a plethora of nonlinear smoothers have been suggested which are hard to analyze. Our methodology is to use a linear mod
Background:Chemotherapy in platinum-resistant ovarian cancer (PROC) aims for palliation and prolonging of progression-free survival (PFS). This study compares Health-related Quality of Life (HRQoL) and efficacy between single-agent chemotherapy and tamoxifen in PROC.Methods:Patients with PROC were randomised (2: 1) to chemotherapy (weekly paclitaxel 80 mg m -2 or four weekly pegylated liposomal do
Whilst 50% of child protection workers across much of Europe and the affluent ‘West’ leave after two years, many stay and develop substantial professional careers. This paper discusses research in Italy, Sweden and England examining what factors explain ‘remaining’ for more than three years in this stressful job. Underpinned by a hermeneutic epistemology, qualitative interviews were undertaken and
Background & Aims: Little is known about the pathogenic mechanisms of gluten immunogenicity in patients with celiac disease. We studied temporal associations between infections and the development of celiac disease autoimmunity, and examined effects of HLA alleles, rotavirus vaccination status, and infant feeding. Methods: We monitored 6327 children in the United States and Europe carrying HLA
Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs
OBJECTIVE: To assess mortality related to musculoskeletal (MSK) disorders and rheumatoid arthritis (RA), specifically, among adults (aged ≥ 20 yrs) in southern Sweden using the multiple-cause-of-death approach.METHODS: All death certificates (DC; n = 201,488) from 1998 to 2014 for adults in the region of Skåne were analyzed when mortality from MSK disorders and RA was listed as the underlying and
A computational framework for modelling damage-induced softening in fibre-reinforced materials is presented. The main aspect of this framework is the proposed non-local gradient-enhanced continuum damage formulation. At the material level, the elastic constitutive behavior is defined by a hyperelastic functional including a volumetric and an isochoric contribution. The isochoric contribution is su
Background: The evaluation of imprecision is a key dimension of the grading of the confidence in the estimate. Grading of Recommendations Assessment, Development and Evaluation (GRADE) gives recommendations on how to downgrade evidence for imprecision, but authors vary in their use. Trial Sequential Analysis (TSA) has been advocated for a more reliable assessment of imprecision. We aimed to evalua
Background: Hand eczema (HE) in healthcare workers (HCWs) is common. Besides wet work, healthcare work also implies exposure to contact allergens. Objectives: To assess HE and contact allergy related to occupational exposures in HCWs. Methods: In a cross-sectional study, 311 HCWs with HE within the preceding 12 months and a control group of 114 HCWs without HE were investigated with the baseline s
Low-density lipoproteins (LDL) are natural lipid transporter in human plasma whose chemically modified forms contribute to the progression of atherosclerosis and cardiovascular diseases accounting for a vast majority of deaths in westernized civilizations. For the development of new treatment strategies, it is important to have a detailed picture of LDL nanoparticles on a molecular basis. Through
Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VO
The Brexit Blog Corpus (BBC) is a collection of texts extracted from political blogs, which, in a recent study, was annotated according to a cognitive-functional stance framework by two independent annotators (Annotator A and B) using semantic criteria (Simaki et al. 2017). The goal was to label the stance or stances taken based on the overall meaning of a set of utterances. The annotators were no
In the transportation literature, equity has been and is still used with a variety of meanings and purposes. Traditionally, equity has been considered in strategic transport planning but very few works have been addressing it in a quantitative way, detailing how to explicitly consider it at a transportation design level (tactical and/or operational) focusing on the consequent social role of transp
This paper examines how a Scandinavian country organises elderly care as a welfare service on a quasi-market. More specifically, it deals with how public officers work with meeting citizens’ need and demand, while at the same time struggle with political decrees, changes in the political climate, as well as the whims of the market. Swedish elderly care is used as an example of how a welfare servic
Water security offers to the local population an adequate quality and quantity of water for health, economy, livelihoods and ecosystems. Hence, achieving basic levels of water security should be a priority in areas where access to fresh water is scarce. The Punata alluvial fan (Bolivia) is a semiarid zone and an important agricultural zone, where the main source of water is groundwater. Therefore,
To assess the benefits of introducing Agile practices, it is important to get a clear understanding of the baseline situation, i.e. the situation before their introduction. Without a clear baseline, we cannot properly assess the extent of impacts, both positive and negative, of introducing Agile practices. This paper provides a preliminary guideline to help researchers in capturing and reporting b
Do female representatives participate less often in legislative debates, and does it matter which topic is debated? Drawing on the role incongruity theory, we hypothesise that women take the parliamentary floor less often because of the gender stereotypes that are likely to guide the behaviour of party representatives. Such underrepresentation is less likely to be present when debates are dealing
