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GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in
Background In patients with stage III cutaneous melanoma, adjuvant treatments with PD-1 and BRAF+MEK inhibitors were approved based on improved recurrence-free survival. However, as the treatments have significant side effects and costs, the effect on overall survival remains a matter of great importance. Methods Clinical and histopathological parameters were obtained from the Swedish Melanoma Reg
Strut-based structures, such as lattices, produced using additive manufacturing (AM) offer significant potential for applications requiring lightweighting and structural compliance. However, conventional Design for AM (DfAM) approaches often assume idealised material behaviour, which can be misleading for thin strut-based structures where geometric parameters and process-induced effects significan
Due to the threat climate change poses, the aviation industry needs to adapt. In the process to convert the aviation fleet into a more environmentally friendly fleet, using biofuels such as Sustainable Aviation Fuels as a drop-in fuel remains a promising option. To include biofuels, safety aspects need to be investigated, where combustion instabilities are important. Thermo-acoustic instabilities
This study examines the ateljé system as a studio-based teaching model used in the first two years of architectural education at Lund University between 2012 and 2022. Based on teaching material, student work, course structures, and the author’s experience, it analyses how learning develops through iterative design work, continuous feedback, and interaction between students.The study shows how con
Background and purpose: Molecularly targeted cancer therapies challenge conventional health economic evaluation frameworks that are structured around tumour-specific indications, comparators, and trial designs. Existing models often rely on pooled estimates from heterogeneous early-phase evidence or single-indication analyses, creating uncertainty for reimbursement decision-makers. We propose a co
This paper explores the changing role and place of handicrafts in contemporary rural development processes. Building on fieldwork conducted in four settlements in northern Thailand and Vietnam, we discuss how a traditional sector is being reshaped under the forces of globalisa- tion and what this means for the character of rural livelihoods. This empirical analysis permits us to reflect on wider a
OBJECTIVES: To identify the lowest sensitivity and specificity that physicians and the general population consider acceptable for medical artificial intelligence (AI), relative to current human performance.METHODS: In a nationwide, cross-sectional survey in Sweden, 2025, random samples of 500 physicians and 500 adults from the general population were mailed a questionnaire presenting three vignett
An increasing number of children grow up in joint physical custody (JPC), prompting interest in how this arrangement affects their development. Particularly, questions about the impact of JPC on early attachment development have placed young children at the forefront of scholarly attention. Yet, no systematic synthesis of research has examined attachment development in young children living in JPC
At the turn of the twentieth century, infant- and child mortality declined rapidly in many industrializing societies. In Sweden, this decline coincided with industrialization and urbanization, as well as a period of growing social disparities in childhood mortality. The inequality in child survival was connected to a range of factors, including access to water- and sanitation, housing conditions,
Bone conduction hearing implant systems (BCHIs) are established treatments for patients with conductive or mixed hearing loss or single-sided deafness when conventional hearing aids are unsuitable. This study evaluated the cost-effectiveness of the active transcutaneous system Sentio versus a similar system, i.e., Osia in an Australian setting. Scenario analyses also compared Sentio to other syste
Most clinical laboratories measure total magnesium (tMg) which includes both the ionized (iMg) and bound forms. Only the ionized component is biologically active, and it may be influenced by acid-base status, plasma protein concentrations and electrolyte disturbances, potentially altering how well tMg reflects iMg. This multicenter observational study evaluated the relationship between tMg and iMg
Introduction: Cervical cancer represents a significant public health challenge worldwide. To improve screening accessibility and participation, we implemented vaginal human papilloma virus (HPV) self-sampling as part of an organized cervical cancer prevention strategy. This study aimed to evaluate the implementation and outcomes of the self-sampling program in a real-world setting. Material and Me
Accurate prediction of groundwater levels (GWL) is essential for effective and sustainable water resource management, particularly in arid and semiarid regions where excessive extraction and climate change significantly accelerate aquifer depletion. The nonstationary characteristics of groundwater data pose significant challenges to the performance and reliability of conventional machine learning
Ambivalence is widely regarded as a source of ontological insecurity and anxiety due to its close association with uncertainty, undecidability, and indeterminacy. While ontological security studies (OSS) has usefully engaged with the concept of ambivalence as an epistemic phenomenon and its manifestations in international politics such as ‘strangers’, almost no attention has been paid to ambivalen
Fokus för denna studie är att undersöka statusen för Norra Bunnsjön och de utmaningar den står inför idag med betoning på vattenresurshantering för ett bättre bevarande av fiskbestånden. För att uppnå målen genomfördes litteraturgranskningar, datainsamling från olika källor och vattenprovtagningar på plats. Resultaten visar att sjön har höga halter av kemiska föroreningar som kvicksilver, kvicksiThe focus of this study it to investigate the status of the Norra Bunn lake and the challenges it is facing today then to address these issues accordingly with a focus on water resources management for a better fish stocks conservation. To achieve the objectives, various literature reviews, data collection from different sources and on-site water samplings are carried out. The study results show
This thesis concerns oaths, curses, and prayers in Roman comedy, more precisely the comedies by the playwriter Terence (185/84 - 159 BC). So-called informal/interjectional oaths and prayers constitute the main focus of this investigation, however, asseverations, formal oaths, formal prayers, and curses are included as well. In this study, carried out by utilizing the methodological frameworks herm
The world is constantly changing, and business strategies are changing with it. Companies are offering new delivery options and technologies for customers globally when doing purchases. IKEA, a global furniture retailer, is expanding their touchpoints by opening retail stores in city centre locations in order to become more accessible. The ways customers travel in urban areas are more varied incl
