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Is the oncogene MYC upregulated or hyperactive? In the majority of human cancers, finding agents that target c-MYC has proved difficult. Here we report specific bacterial effector molecules that inhibit cellular MYC (c-MYC) in human cells. We show that uropathogenic Escherichia coli (UPEC) degrade the c-MYC protein and attenuate MYC expression in both human cells and animal tissues. c-MYC protein
Aim: The first Swedish National Guidelines for Ovarian Cancer (NGOC) were published in 2012. We aimed to evaluate surgical outcomes and survival in patients with stage IIIC-IV disease, before and after the NGOC implementation. Method: Women with primary epithelial ovarian cancer, FIGO stage IIIC–IV, registered in the Swedish Quality Registry for Gynecologic Cancer 2008–2011 and 2013–2016 were incl
Quenching of vibrational excitations in resonant inelastic X-ray scattering (RIXS) spectra of liquid acetic acid is observed. At the oxygen core resonance associated with localized excitations at the O–H bond, the spectra lack the typical progression of vibrational excitations observed in RIXS spectra of comparable systems. We interpret this phenomenon as due to strong rehybridization of the unocc
This chapter explores Turkish museal display as an arena for memory-cultural Islamisation, extending beyond the walls of museums. It probes museums as spaces for exhibiting nationalism, and the burgeoning interest in religion and affect within a new museology. It discusses how Turkish expositions have appropriated aspects of such a new museology in restorative-commemorative expositions of the Otto
Warriors and warfare have become common themes within Bronze Age archaeology the past 10 -20 years. Recent reporting of Neolithic and Bronze Age massacres and battlefields in Germany supports endemic violence in these regions. But what about in southern Scandinavia? This paper explores the evidence of violence related skull trauma from a pooled sample of 257 individuals from 40 different localitie
Nätläkare, vårdgivare som tillhandahåller sjukvårdstjänster via smartphoneappar, har gått från att vara perifera inslag i den svenska sjukvården till att på allvar utmana det konventionella sättet att bedriva sjukvård. Den tillgänglighet som nätläkare erbjuder är oöverträffad men alla patientgrupper har inte sett sin tillgång till vård förbättras i samma utsträckning tack vare nätläkare.Syftet medOnline doctor services, healthcare provided via smartphone apps, have gone from being peripheral to seriously challenging the conventional Swedish way of providing healthcare services. The accessibility of online doctors is unsurpassed but all patient groups have not gotten better access to healthcare thanks to online doctors.The aim of this study was to investigate how perceptions of the online d
γ-CoV2O6 is a quasi-one-dimensional spin-3/2 magnet that possesses two distinct magnetic orders at low temperatures with propagation vectors k1=(½,0,0) and k2=(¼ + δh, δk, - ¼ + δl), respectively. Here we use muon spin relaxation and rotation to reveal the thermodynamics of the magnetic phase separation in this compound. In the paramagnetic (PM) region, short-range correlated spin clusters emerge
This chapter provides a reassessment of the waste ‘crises’ in the so-called Land of Fires in Italy and highlights the contribution of local social mobilizations in advancing environmental justice and sustainability concerns. It is based on the long term collaboration between a social scientist and two activists, and it draws from a dialogue of academic and activist knowledge in the tradition of En
For the perennial herb G. fastigiata on the Baltic island of Oland, there were significant correlations between electrophoretic variation at the PGI-2 locus and fine-scale gradients of compositional change in the limestone grassland plant communities occupied by G. fastigiata. Variation at the AAT-3 and IDH loci and in seed phenotype showed no significant correlations with plant community composit
The changing landscape of science and science education has provided an impetus to re-imagine how science can be taught in schools. The dawn of the Big Data era, especially in astronomy, and the notion of “Science as Practice” are some of the developments driving this need for a re-imagination of science education. This current work contributes to this agenda by exploring the features an education
Denna studie kretsar kring pheriwale, en grupp egenföretagare inom Indiens stora informella ekonomi. Pheriwale har livnärt sig på handel i Delhi under nästan ett sekel och sysslar med handel med begagnade kläder. De är en av de mest tydligt kvinnodominerade grupperna av gatuhandlare och -försäljare i staden. Genom att knacka dörr hos invånare i staden och förorten sysslar de med byteshandel och saThis study revolves around the working lives of pheriwale, a group of self-employed traders within India’s vast informal economy. Pheriwale have been trading in Delhi for nearly a century and are involved in the second-hand clothing trade. Among the wide variety of street vendors and traders in the city, pheriwale are one of the most visibly women-dominated. They offer a door-to-door service, coll
Key message: Dynamic global vegetation models are key tools for interpreting and forecasting the responses of terrestrial ecosystems to climatic variation and other drivers. They estimate plant growth as the outcome of the supply of carbon through photosynthesis. However, growth is itself under direct control, and not simply controlled by the amount of available carbon. Therefore predictions by cu
Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical illness affecting 6-8 million people in Latin America. Reaching scholarly consensus on the host response to T. cruzi infection remains a significant challenge, primarily due to substantial heterogeneity in outcomes driven by both the choice of animal model and the infecting parasite's discrete typing unit (DTU). This var
What is the effect of punching holes at random in an infinite tensed membrane? When will the membrane still support tension? This problem was introduced by Connelly in connection with applications of rigidity theory to natural sciences. The answer clearly depends on the shapes and the distribution of the holes. We briefly outline a mathematical theory of tension based on graph rigidity theory and
Obesity may exacerbate colorectal cancer (CRC) prognosis, yet previous studies have shown inconsistent findings due to methodological limitations. In this nationwide cohort study, we investigated the association between body mass index (BMI) on CRC recurrence and mortality, while examining the influence of demographic, clinical, and socioeconomic characteristics. From the Danish Colorectal Cancer
Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for
Antimicrobial resistance (AMR) poses a major threat to global health, with limited surveillance data available from western sub-Saharan Africa. After reports of high rates of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) in bloodstream infections at The Gambia’s sole tertiary hospital, we present follow-up data after enhancements in microbiology cap
Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind
