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Background: Prostate cancer is a leading cause of death in the male population of the western world. Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is regulated by the androgen receptor. 11B6 is a murine IgG(1) monoclonal antibody directed against free human hK2. In this study, we performed a preclinical evaluation of In-111-la
The ALICE Collaboration reports the measurement of the relative J/psi yield as a function of charged particle pseudorapidity density dN(ch)/d eta in pp collisions at root s = 7 TeV at the LHC. J/psi particles are detected for p(t) > 0, in the rapidity interval vertical bar y vertical bar < 0.9 via decay into e(+)e(-), and in the interval 2.5 < y < 4.0 via decay into mu(+)/mu(-) pairs. An approxima
The charge state of proteins in solution is a key biophysical parameter that modulates both long and short range macromolecular interactions. However, unlike in the case of many small molecules, the effective charges of complex biomolecules in solution cannot in general be predicted reliably from their chemical structures alone. Here we present an approach for quantifying the effective charges of
Pro-inflammatory protein S100A9 was established as a biomarker of dementia progression and compared with others such as Aβ1-42 and tau-proteins. CSF samples from 104 stringently diagnosed individuals divided into five subgroups were analyzed, including nondemented controls, stable mild cognitive impairment (SMCI), mild cognitive impairment due to Alzheimer's disease (MCI-AD), Alzheimer's disease (
Context and Objective: Intraportal islet transplantation can restore insulin production in type 1 diabetes patients, but its effect is subject to several interfering processes. To assess the influence of beta-cell loss before and during engraftment, we searched for a real-time marker of beta-cell destruction. Previous studies showed that 65-kDa isoform of glutamate decarboxylase (GAD65) is dischar
Background: HTLV-1 is endemic in Guinea-Bissau, and the highest prevalence in the adult population (5.2%) was observed in a rural area, Caio, in 1990. HIV-1 and HIV-2 are both prevalent in this area as well. Cross-sectional associations have been reported for HTLV-1 with HIV infection, but the trends in prevalence of HTLV-1 and HIV associations are largely unknown, especially in Sub Saharan Africa
Far-field three dimensional x-ray diffraction (3DXRD) data acquired by repetitive acquisitions with a beam much smaller than the sample width is sometimes referred to as scanning-3DXRD. We here analyse the scanning 3DXRD approach and present a novel reconstruction technique capable of reconstructing intra-crystal variations in crystal structure from a set of recorded 2D diffraction patterns. The m
Elnät är komplexa och vidsträckt system som förlitar sig på alla sina beståndsdelar för att bibehålla en god driftsäkerhet och stabilitet. Den ökade andelen vind- och solkraft utgör ytterligare ett dynamiskt element i de redan komplexa systemen. En analys och behandling av riskerna kan bidra till en säker övergång, där påverkan på hälsa, miljö och ekonomi är minimal. Studien är utformad utifrån etThe electric utility system is complex and dependent on all of its constituents for attaining a reliable distribution. The increase of solar and wind power adds a new dynamic element to this system. Risk management methodology can help in facilitating a safe and sustainable transition, achieving minimal negative impact on society, environment and economy. The working process of the Thesis is const
Protected areas (PAs) embody a historical legacy of value contestation and human exclusion. While the rise of community-based conservation in the 1980s sought to reconfigure this mechanism by running a counter narrative arguing that biodiversity conservation and development were mutually reinforcing objectives, exclusionary PAs continue to maintain a strong position in the conservation discourse.
Early childhood education and care has been stated a key priority area for governmental investment of the education sector in Brazil since the early 2000s and was reaffirmed as the number one target of the 2014 national education plan. Nonetheless, services remain inadequate in regards to both coverage and quality. A vast amount of existing research indicates that early childhood education and car
Purpose: In order to study the Galactic Chemical Evolution, elemental abundances are needed. The purpose of this work is to investigate the chemical evolution of the Milky Way by determining several elemental abundances of giants in the local disk. Large surveys are up and coming, and several surveys are already working, and with these, the aim is high quality abundance measurements of several ele
In a modern-day circular economy context, there is a dire need for companies all over the world to change and adapt their business model from linear to circular. This thesis is thus dedicated to deepening the understanding of business models in circular transition, by looking at effects on the specific business model components: value proposition, value creation and delivery, and value capture (as
This thesis explores the nature of the challenges local NGOs face when responding to the humanitarian crisis in Venezuela. In doing so, it draws on material collected from distance interviews with Venezuelan NGOs involved in delivering humanitarian aid and on qualitative analysis of political statements from members of the Venezuelan government. Further, it investigates whether and how identified
This thesis conducts an auteur analysis of John Ford films containing submarines with the method of textual analysis. The films that are being analyzed are The Blue Eagle (1926), Men Without Women (1930), Seas Beneath (1931), Submarine Patrol (1938) and The Growler Story (1958). The purpose is to find out which distinctive auteur themes that can be identified in each of these films. The results in
This thesis examines user reviews of the video game Wolfenstein II: The New Colossus (Machine games 2017). From a total of 560 reviews, 176 reviews engaging with social and political issues in the game was selected for a critical discourse analysis. A close reading of the games politics of gender and race being negotiated in the reviews show how performances of (successful) masculinity and (believ
The global transport industry stands in front of the next big technology shift; the implementation of autonomous vehicles. This shift might remove the physical driver from the truck, increase safety and improve flexibility. This will most likely change the fundamentals of the transportation industry. Autonomous trucks are anticipated to be implemented for short distance transportation in gated are
The 1994 genocide against the Tutsi in Rwanda, during which Hutu and others who opposed the genocide were also killed, tore up the social fabric of Rwanda. The reconciliation effort has been immense involving actors from all walks of life all working with different methods and techniques. This study turns to the beautiful game, football, and aims to examine what role the sport has played in the po
Density is often used as a strategy to achieve a sustainable development in contemporary urban planning. A higher concentration in the urban environment of functions and people are argued to be essential to handle the climate change as well as achieving social equity. While a desire for higher density is often formulated in urban development plans by regions or municipalities, there lies a confusi
