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Background/Aim: The TGF-β pathway can influence breast cancer progression and therapy efficacy, exhibiting both pro- and anti-tumoral effects. This study examined the impact of active TGF-β signaling on recurrence and radiotherapy (RT) benefit in early-stage breast cancer, using nuclear phosphorylated Smad2 (pSMAD2) as a marker for pathway activation. Methods: Tissue-microarrays from 1178 stage I-
In Sweden mental ill-health has increased among the young, especially among young women. Our aim was to investigate the association between experience of physical violence during the past year and self rated psychological health among young men and women.
Changes in agricultural management have been identified as the most probable cause for the decline of Skylark (Alauda arvensis) populations in Europe. However, parasitic infections have not been considered as a possible factor influencing this process. Four hundred and thirty-four Skylarks from the Southern Italy and the Netherlands were screened for haemosporidian parasites (Haemosporida) using t
PURPOSE: A Swedish and Norwegian study was designed to examine health-related quality of life (HQL) in patients with head and neck cancer (head and neck) at diagnosis and during treatment and rehabilitation. The overall aim was to examine the impact on HQL at diagnosis depending on tumor location, stage, sex, and age (part I) and to describe HQL longitudinally and determine for which patients and
Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to
The decays of the high angular momentum, high spin F-4(0) states of the electron configuration 3s3p3d in aluminium-like ions (with three electrons outside a closed shell) have been identified in delayed spectra of foil excited Ti, Fe and Ni ion beams. The line identifications were aided by HXR, MCHF, and MCDF calculations and are corroborated by lifetime measurements which demonstrate the differen
This study examined to what extent the decentralised drinking water management system in Mahoba district, Uttar Pradesh, India, is participatory. The central questions focused on how participation is taking place, what socio-political factors affect participation, and how the community members explain their capability to participate. Methodologically the study was interpretivist in nature and base
The purpose of this paper was to understand post-war Sri Lanka. For about thirty years there was a raging armed conflict in Sri Lanka between the Sri Lankan Army (SLA) and the Liberation Tigers of Tamil Eelam (LTTE). The war ended in 2009 and left behind clusters of Internally Displaced Persons (IDPs)and child recruits; unforcibly or forcefully recruited by the LTTE. The Government of Sri Lanka (G
Aim: The aim of this observational study was to investigate relationships between physiological levels of glucometabolic biomarkers and cognitive test results in a population-based setting. Methods: Cross-sectional data were obtained from the Swedish population-based Malmö Diet and Cancer Study Re-examination 2007–2012 comprising 3001 older people (mean age 72 years). Through oral glucose toleranc
Background: Fine roots and their symbionts are the key drivers of processes such as nutrient cycling and belowground productivity. Their function depends on position in a branching hierarchy, with absorptive roots (responsible for resource acquisition), and transport roots. Aim: We examined how the different diameter cutoffs for root classification mirror concentrations of 11 different nutrients,
Objective: Both psoriatic arthritis (PsA) and rheumatoid arthritis (RA) have a significant impact on quality of life, but few reports have compared the two diseases. The current study assessed health-related quality of life (HRQoL) in PsA at diagnosis and after five years compared with early rheumatoid arthritis (RA) and a matched general population. Methods: Patients with early PsA and early RA i
Aim: To discuss specialist operating theatre nurses’ competence in relation to the general six core competencies and patient safety. Design: A discursive analysis of legal statutes and scientific articles. Methods: Swedish legal statutes and an overview of scientific articles on operating theatre nursing were deductively analysed and classified into healthcare providers’ general six core competenc
Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducib
The use of artificial intelligence in law represents one of the biggest challengesacross different legal systems. Supporters of predictive systems believe thatdecisionmaking could be more efficient, consistent and predictable by usingAI. European legislation and legal scholars, however, identify areas where AIdevelopments are at high risk or too dangerous to be used in judicial proceedings.In thisThe use of artificial intelligence in law represents one of the biggest challenges across different legal systems. Supporters of predictive systems believe that decisionmaking could be more efficient, consistent and predictable by using AI. European legislation and legal scholars, however, identify areas where AI developments are at high risk or too dangerous to be used in judicial proceedings. In
BACKGROUND AND OBJECTIVE: A post hoc analysis of TITAN evaluated the clinical benefit of apalutamide plus androgen-deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (mHSPC) with high disease burden. METHODS: Patients were assessed in subgroups of those with four to fewer than ten, ten to <20, or ≥20 bone metastases; with lung but not liver metastases; and w
Introduction: The optimal timing for distal radial fracture fixation remains controversial. Most previous studies have dichotomized timing into early or delayed categories, potentially obscuring the true effect of delay. This study investigated surgical timing as a continuous variable to determine its influence on radiographic alignment. Methods: In a retrospective multicentre cohort study, we rev
Physiologically based pharmacokinetic (PBPK) models offer the ability to simulate and predict the biodistribution of radiopharmaceuticals and have the potential to enable individualised treatment planning in molecular radiotherapy. The objective of this study was to develop and implement a whole-body compartmental PBPK model for peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE
