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Exploring emotional relationships between user and product is an important issue to adress in the design of t non-discriminating everyday products. Universal design is one approach among several, which the industrial designer can use when designing on the basis of on a non-discriminating philosophy. One way to achieve an integration of the user product relationship into the concept of universal de

Abstract - Vol. I In this Volume of the thesis, which consists of two volumes, a risk analysis framework for application in the maritime transport system of packaged dangerous goods (PDG) is presented. In many countries, dangerous goods risks have been ranked high among public concerns. Such concerns are mainly due to the increasing volume of dangerous goods, human safety and health and environme

The near-field characteristics of a turbulent jet with moderate swirl generated by a fully developed, axially rotating pipe flow are investigated with LDV, time-resolved stereoscopic PIV measurements, as well as with large-eddy simulations. Large-scale vortical structures in either double, triple or even quadruple-helix configuration are found at the pipe exit but rapidly break down or amalgamate

Non-linear waves have been a research topic for a long time, but have not yet entered common ocean engineering practice. In this article the problem of calculating the probability density function (pdf) for non-linear waves is investigated. The 'saddle point approximation' is applied to a second-order wave model to estimate the pdf. The performance of the approximation is compared with the perform

Background Atopic dermatitis (AD) affects health and quality of life (QoL) and also has great impact on both healthcare costs and costs to society. Objectives The aim of the study was to analyse the cost-effectiveness of treatment with tacrolimus ointment vs. standard treatment in patients with moderate to severe AD. Methods A Markov simulation model was constructed capturing several key features

Although the importance of New Institutional Economics and the institutional approach for understanding pre-industrial economic development and the early growth of markets are widely accepted, it has proven to be difficult to assess more directly the effects of institutions on the functioning of markets. This paper uses empirical research on the rise of markets in late medieval Holland to illumina

In the present study, the daily dose in terms of particle surface area received by citizens living in five cities in Western countries, characterized by different lifestyle, culture, climate and built-up environment, was evaluated and compared. For this purpose, the exposure to sub-micron particle concentration levels of the population living in Barcelona (Spain), Cassino (Italy), Guilford (United

Aims: Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO2), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO2 could be a marker for mortality in the high-r

Coagulation activation and venous thromboembolism (VTE) are hallmarks of cancer; however, there is an unmet need of improved biomarkers for individualized anticoagulant treatment. The present sub-study of the RASTEN trial was designed to explore the role of coagulation biomarkers in predicting VTE risk and outcome in a homogenous cancer patient population. RASTEN is a multicenter, randomized phase

This article picks up on a term (‘cross-fertilisation’) often exploited in debates on the interaction of international laws and legal practices, especially in the context of international criminal law. Two questions are addressed: (1) What is the meaning of ‘cross-fertilisation’? (2) What are its conditions? As the article argues, ‘cross-fertilisation’ pertains to the understanding of legal uttera

Background: People in treatment for substance use disorder commonly have comorbid personality disorders, including antisocial personality disorder. Little is known about treatments that specifically address comorbid antisocial personality disorder. Methods: Self-rated help received for antisocial personality disorder was assessed during follow-ups at 3, 9 and 15 months post-randomization of a rand

Dynamic nuclear polarization of (13)C-labeled cell substrates has been shown to massively increase their sensitivity to detection in NMR experiments. The sensitivity gain is sufficiently large that if these polarized molecules are injected intravenously, their spatial distribution and subsequent conversion into other cell metabolites can be imaged. We have used this method to image the conversion

Several recent international publications (e.g. Platzack 1996, 2001; Håkansson, Pienemann & Sayehli 2002; Pienemann 1998; Pienemann & Håkansson 1999) have claimed that learners take the same developmental route in the acquisition of syntax of a second or foreign language, irrespective of their first language (L1). Targetlike verb placement in a Germanic V2 language like German, Dutch or Sw

The possibility of accurately identifying thermal material parameters on the basis of a simple tension test is presented, using a parameter identification framework for thermo-mechanically coupled material models on the basis of full field displacement and temperature field measurements. Main objective is to show the impact of the material model formulation on the results of such an identification

Increasingly, scholarly debates and policy developments on citizen participation in energy transitions have included calls for ‘energy democracy’ and active forms of ‘energy citizenship’. The concepts are tightly connected to the debate on energy transition, and the need for a decentralised energy system, based on renewable energy and increased local energy ownership. The two concepts exist in par

This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb−1 of proton–proton collision data at a centre-of-mass energy s=13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the bb¯bb¯, bb¯W+W−, bb¯τ+τ−, W+W−W+W−, bb¯γγ and W+W−γγ final states. Results are presented