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Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when overexpressed, plays a role in insulin resistance (Ahmad et al. 1997). We identified, in the 3' untranslated region of the PTP1B gene, a 1484insG variation that, in two different populations, is associated with several features of insulin resistance: among male individuals, higher values of the insulin resistance HOMA(IR)
Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical feasible and noninvasive prospective protocol for intervention of cardiovascular side effects. HL patients diagnosed between 1965 and 1995 (n = 6.946) and their first-degree relativ
A role for genetic factors in the etiology of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) is implicated based on prior findings from multiply affected families and small case-control and cohort studies. We identified 2144 LPL/WM patients (1539 WM [72%] and 605 LPL [28%]) diagnosed in Sweden, 8279 population-based matched controls, and linkable first-degree relatives of patien
In the light of technological changes, changes in business contexts, decreased number of IS students, changes in educational systems, etc., IS education commentators have urged the IS community to develop new and alternative IS curricula. In response to this, we present a model curriculum for a Bachelor of Science program in business information systems design (BISD 2007). The curriculum has a str
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This study examines elaborate prayer practices among peasant communities in late medieval Sweden. The work focuses on the perspectives of ideals and practices, namely the standards of prayer, devotional prayer, and prayer in times of need and prayer cultures.
Health care expenditures have increased rapidly in most OECD-countries, and several reforms have been considered for the improvement of cost-containment in the health care sector. Physicians in particular have been recognized to have considerable impact on health care expenditures and as a result they have become increasingly involved in budgetary control with the hope of a more efficient use of r
Abstract in UndeterminedModern standard written Chinese has two common object markers, ba and jiang. Both markers appear to have been widely used in the spoken language of the Tang dynasty. Today jiang has disappeared from the dialects and subdialects of northern China and it is mainly used in the Yue dialect (Cantonese). Object marker ba in vernacular-oriented writings has gradually replaced jian
The generation of ab initio three-dimensional (3D) models is a bottleneck in the studies of large macromolecular assemblies by single-particle cryo-electron microscopy. We describe here a novel method, in which established methods for two-dimensional image processing are combined with newly developed programs for joint rotational 3D alignment of a large number of class averages (RAD) and calculati
