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OBJECTIVE—Insulin detemir is a soluble long-acting basal insulin analog designed to overcome the limitations of conventional basal insulin formulations. Accordingly, insulin detemir has been compared with NPH insulin with respect to glycemic control (HbA1c, prebreakfast glucose levels and variability, and hypoglycemia) and timing of administration. RESEARCH DESIGN AND METHODS—People with type 1 d
Objective:To determine whether the combined intervention of 50 000 IU vitamin A administered together with Bacille Calmette-Guerin (BCG) vaccination at birth was associated with adverse events, in particular bulging fontanels and adverse reactions to BCG.Subjects/Methods:From an ongoing trial, 2145 infants randomized to 50 000 IU vitamin A or placebo with BCG vaccination were recruited. Adverse ev
The paper examines the nonlinear behaviour of one- and two-degree-of-freedom discrete mechanical models subjected to partial follower load under conditions at which divergence instability occurs. Section (1.6) of the paper deals with the dynamic instability of an elastoplastic damped strut compressed by partial follower force at the free end. Space-time curves for the system are presented and disc
Historically, agriculturally induced CO2 release from soils has contributed to rising levels in the atmosphere. However, by using appropriate management, soils can be turned into carbon sinks. Many of the dryland regions of the world are characterised by degraded soils, a high incidence of poverty and a low capacity to invest in agriculture. Two well-proven soil organic matter models (CENTURY 4.0
Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTR
Autonomic and peripheral nerve functions as well as the possible short-term effect of a novel aldose reductase inhibitor (ARI) on neuropathy were evaluated in 30 male type I diabetics (age 25-44 years, mean 34; duration of diabetes 10-20 years, mean 34) with neurographic signs of peripheral neuropathy (PN). Autonomic neuropathy (AN) was established by the heart rate reactions to deep breathing (E/
This book deals with ’have’ in ancient Greek. Two different types of ’have’-constructions were used, viz., on the one hand, the active transitive verb ἔχω and, on the other hand, the verb εἶναι, ’be’, with a complement in the dative case (here called the ἔστι μοι construction). A transitive ’have’ does not seem to be of Proto-Indo-European origin but rather an innovation in separate Indo-European
Background: Individuals belonging to the same family share a number of genetic as well as environmental circumstances that may condition a common SBP level. Among the genetic factors, the angiotensin converting enzyme (ACE) gene I/D polymorphism appears as a possible candidate as it might influence both SBP and the pharmacological effect of ACE inhibitors. We aimed to combine genetic epidemiology
A method based on computational fluid dynamics (CFD) for the characterization of static mixers using the Z factor, helicity and the rate of striation thinning is presented. These measures were found to be well-suited for the characterization of static mixers as they reflect the pressure drop, the formation of secondary flow, i.e. vortices, and their effect on the mixing process. Two commercial sta
PURPOSE: To compare the diagnostic results following injection of (a) a high dose (0.3 mmol/kg b.w.) of gadodiamide injection and (b) the standard dose (0.1 mmol/kg b.w.) of Gd-DTPA, in patients with recurrent symptoms after surgery for lumbar disc herniation. MATERIAL AND METHODS: Twenty patients with recurrent or sustained symptoms after surgery for lumbar disc herniations were examined. MR imag
Chironomid remains from the sediment of Lake Vuolep Njakajaure reflect limnological conditions resulting from changing climate and vegetation throughout the Holocene, but do not strictly follow accepted climate trends or the vegetation history based on regional pollen and macrofossil analyses. Chironomid community changes appear to be influenced by organic nutrient input from the surrounding catch
On the origin, use and dating of the customary of the cathedral chapter of Lund, i.e. the Consuetudines Lundenses. I have argued that the consuetudines were used by the canons from 30 June 1123 at the latest, the day of inauguration of the crypt church. This seems even more plausible as the prototype of the text, i.e. the Consuetudines Marbacenses, were recently antedated. Furthermore, these circu
BACKGROUND: Death of smooth muscle cells in the atherosclerotic plaques makes the plaques more prone to rupture, which can initiate an acute ischemic event. The development of atherosclerosis includes the migration of immune cells e.g. monocytes/macrophages and T lymphocytes into the lesions. Immune cells can release antimicrobial peptides. One of these, human cathelicidin antimicrobial peptide hC
The academic discourse on the need for a shared political public sphere at the level of the European Union has in recent years produced the conventional wisdom that such an emerging transnational community of communication is already observable in the mass media. However, the empirical indicators on which this notion is based tend to accommodate parallel national public spheres rather than a genui
The acyl-coenzyme A-binding proteins (ACBPs) contain 26 highly conserved sequence positions. The majority of these have been mutated in the bovine protein, and their influence on the rate of two-state folding and unfolding has been measured. The results identify eight sequence positions, out of 24 probed, that are critical for fast productive folding. The residues are all hydrophobic and located i
Mantle cell lymphoma (MCL) is an aggressive lymphoid malignancy for which better treatment strategies are needed. To identify potential diagnostic and therapeutic targets, a signature consisting of MCL-associated genes was selected based on a comprehensive gene expression analysis of malignant and normal B cells. The corresponding protein epitope signature tags were identified and used to raise mo
Aims: To determine the effects of a nurse-led intervention designed to improve self-management of patients with heart failure in a primary health care setting regarding health-related quality of life and depression. Methods: Patients at eight primary health care centres were screened by the Diagnosis Related Groups registry for the diagnosis of heart failure and eligibility for a cluster randomise
Objective: To analyse the influence of socio-demographic characteristics and environmental factors on self-reported somatic and psychological symptoms among middle-aged Swedish women. Methods: A total of 6917 women living in the Lund area of southern Sweden were participates of this study. They completed a generic questionnaire pertaining to socio-demographic characteristics, lifestyle factors and
Background. The purpose of this study was to evaluate late effects and symptom complaints in long-term survivors (>5 years) of Extremity Bone Sarcoma (EBS Survivors). The results were compared with findings in age- and gender-matched individuals from the general Population (NORMs). Patients and Methods. Among 155 EBS Survivors approached, 133 (86%) were included, and 110 of them (83%) attended an
Levels of persistent pollutants, including PCBs, SIGMADDT, and gamma-hexachlorocyclohexane, were examined in a pike population inhabiting a eutrophic lake in southern Scandinavia. For females, levels of persistent pollutants decreased linearly with age, weight, or length. This decline was ascribed to the seasonal elimination of the lipophilic pollutants in roe, which contained up to 10 times highe
