Sökresultat

This paper deals with the potential grammaticalization of English (it) could be and (it) might be into epistemic sentence adverbs in analogy to maybe. They can occur in adverb-like positions and functions in informal language use, e.g. (it) could be something good has begun, often with the pronoun it omitted. But, given that no diachronic development is attested, to what extent does their usage inThis paper deals with the potential grammaticalization of English (it) could be and (it) might be into epistemic sentence adverbs in analogy to maybe. They can occur in adverb-like positions and functions in informal language use, e.g. (it) could be something good has begun, often with the pronoun it omitted. But, given that no diachronic development is attested, to what extent does their usage in

The Japanese government's approval ratings are dropping fast ahead of elections in July

The most common cause of autosomal recessive familial Parkinson's disease (PD) are mutations in the PRKN/PARK2 gene encoding an E3 ubiquitin protein-ligase PARKIN. We report the generation of an iPSC cell line from the fibroblasts of a male PD patient carrying a common missense variant in exon 7 (p.Arg275Trp), and a 133 kb deletion encompassing exon 8, using transiently-present Sendai virus. The e

The dependence of the diffusion MRI signal on the diffusion time carries signatures of restricted diffusion and exchange. Here we seek to highlight these signatures in the human brain by performing experiments using free gradient waveforms designed to be selectively sensitive to the two effects. We examine six healthy volunteers using both strong and ultra-strong gradients (80, 200 and 300 mT/m).

The idea of facilitating labour mobility for refugees as a pathway for admission is back on the policy agenda. Such complementary pathways are promoted in the Global Compact for Refugees as means to facilitate access to protection and solutions in addition to resettlement, and praised by United Nations High Commissioner for Refugees as directly contributing to easing pressure on host countries by

Background: Real-World evidence on mesenchymal-epithelial transition exon 14 skipping mutations (METex14) in lung cancer remains limited. With an incidence of 3–4% across histological subtypes, METex14 is now an actionable target for MET inhibitors (METi) in advanced lung cancer, demonstrating response rates between 30–70%. Yet, its role in early stages and sensitivity to immune checkpoint inhibit

Background: The existing association between skin disease and psychiatric comorbidity has gained attention during the last decades. Stress and mental illness can directly or indirectly affect skin disease, while dermatological conditions, known to impair life quality and mental well-being, can promote psychiatric conditions. Objectives: The aim of this study was to assess the risk of developing ps

Introduction: Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple sources of uncertainty, many of which can be overcome by using traceable, sealed, long-lived surrogate sources containing a radionuclide of comparable energies and emission probabilit

BACKGROUND: There are few data on outcomes after reintervention for persistent or recurrent primary hyperparathyroidism (PHPT). The authors hypothesized that the variation in outcomes at the hospital level after reoperation would be significant. After accounting for this variability, some patient-level clinical criteria could be identified to help inform treatment decisions in this patient populat

Background: There is limited information on the distribution of retroperitoneal lymph node metastases (LNMs) in upper tract urothelial carcinoma (UTUC). Objective: To investigate the location of LNMs in UTUC of the renal pelvis or proximal ureter and short-term complications after radical nephroureterectomy (RNU) with lymph node dissection (LND). Design, setting, and participants: This was a prosp

We investigated the relationship between hs-CRP, a marker of low-grade inflam-mation, alone or in combination with C-peptide, a marker of hyperinsulinemia/ insulin resistance, and risk for cardiovascular events (CVEs) and mortality in patients recently diagnosed with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In patients with recent-onset T2D, we measured serum hs-CRP (n = 7,301) and C-pep

It is a well-known fact that when we in Korea find elaborate polite conjugations, that structure and determine everyday interaction, the Danes, on the other side of the Globe, have a habit of saying ‘you’ (‘du’) in almost every context. We are dealing with an Asian language ruled by a high level of honorific phrases and a Scandinavian language characterized by its more unpolished and straightforwa

BACKGROUND: Ketamine has considerable therapeutic potential in alleviating major depressive disorder and chronic suicidality. However, the clinical diagnosis of neuropsychiatric disorders requires more robust diagnostic criteria. Electroencephalography (EEG) has shown promise in classifying depressive and suicidal patients from healthy individuals. The present study aimed to identify changes in th

The newly emerged pathogen, Candida auris, presents a serious threat to public health worldwide. This multidrug-resistant yeast often colonizes and persists on the skin of patients, can easily spread from person to person, and can cause life-threatening systemic infections. New antifungal therapies are therefore urgently needed to limit and control both superficial and systemic C. auris infect

BACKGROUND: Observational studies have revealed that type 2 diabetes (T2D) is associated with an increased risk of peripheral artery disease (PAD). However, whether the two diseases share a genetic basis and whether the relationship is causal remain unclear. It is also unclear as to whether these relationships differ between ethnic groups.METHODS: By leveraging large-scale genome-wide association

Background: The period after a child is discharged from hospital is generally described as challenging for the parents. Their satisfaction with the health services received is an important indicator of the quality of care. eHealth devices are increasingly used in health care to support communication with parents. Differences in levels of parental satisfaction by modality of provided care or by par

Climate and environmental activists in Sweden have never been more confrontational than now. However, despite previous research on social movements giving reason to expect a radicalisation and turn to political violence within the environmental movement, such a development has so far not occurred. This thesis examines the views and attitudes towards political violence directed at inanimate objects

Aviation policy within the European Union (EU) plays a pivotal role in shaping the aviation industry. This thesis examines the extent to which the EU’s regulatory discourse effectively promotes sustainable development norms in aviation policy, focusing on the Regulation (EU) 2018/1139. Employing a multi-level Critical Discourse Analysis (CDA) framework developed by Fairclough (1995), the study ana

Technological development has empirically demonstrated significant social impact across diverse global contexts. The uncertainty of the effects necessitates continuously updated research and historical revision to foster sustainable processes and address research gaps. Traditional economic optimism tends to overlook multidimensional compositions of effects, beyond financial gains. This paper exami