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Vincristine is a key drug in the treatment of childhood and adult acute lymphoblastic leukemia (ALL), and many other childhood malignancies. Despite decades of wide clinical use, no data on the correlation between vincristine pharmacokinetics and long-term clinical outcome have been published. We here report clinical data (median follow-up time 10.5 years, range 7.3-12 years) for 86 children with
We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)pyridine (NNC77-0074) on stimulus-secretion coupling in isolated pancreatic alpha- and beta-cells. NNC77-0074 stimulated glucose-dependent insulin secretion in intact mouse pancreatic islets. No effect was observed at less than or equal to 2.5 mM glucose and maximal stimul
In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of
The intestine represents the body’s largest surface exposed to the outer world and is thus a major entry site for pathogens such as bacteria and viruses. The intestinal immune system has the important task of protecting us against infection while maintaining tolerance against the vast amount of commensal microbes populating the intestinal tract and the multitude of foreign antigen present in the d
Popular Abstract in Swedish De semi-arida regionerna i norra Kina är drabbade av många faktorer som påverkar miljön negativt, t.ex. ökenspridning, vind erosion, överbetning, uttömmande av naturresurser. Det redan hårda trycket på ekosystemen i dessa regioner har ökat sedan Kina införde marknadsekonomi. Reformerna sedan 1978 har lett till en snabb ökning av antalet betesdjur och en expansion av jorLand degradation is commonly perceived to be severe in many parts of semi arid China. The transition towards market economy since the 1978 reforms, have set marginal dry lands under added pressure in the form of increased livestock numbers and expanding cultivation on erosive soils. To evaluate land degradation since the reforms, this study focuses on mapping and analysing the biological productio
Wild-type (F/B), constitutively active (F/B*), and three kinase-inactive (F/Ba-, F/Bb-, F/Bc-) forms of Akt/protein kinase B (PKB) were permanently overexpressed in FDCP2 cells. In the absence of insulin-like growth factor-1 (IGF-1), activities of PKB, cyclic nucleotide phosphodiesterase 3B (PDE3B), and PDE4 were similar in nontransfected FDCP2 cells, mock-transfected (F/V) cells, and F/B and F/B-
Using bird atlas data from south-central Sweden and information on survey effort for the corresponding 5 x 5 km grid squares, we assessed how much time is required to get reliable presence/absence data for forest birds. We restricted the analyses to a suite of 28 species considered common enough and sufficiently generalised in their requirements to be present in all survey squares largely dominate
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Introduktion Cancer uppstår när en cell i kroppen börjar dela sig okontrollerat, varmed det sker en onaturlig ansamling av celler ? tumörbildning. Solida tumörer t ex bröst- och prostatacancer är till skillnad från ickesolida tumörer som blodcancer/leukemi ofta dåligt försedda med syre på grund av långa avstånd mellan tumörceller ochNeuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. In earlier studies we have found that hypoxia induces dedifferentiation of neuroblastoma cells, which implies that hypoxia evokes a more aggressive phenotype. Here we employ microarray
A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) and published in 1996. The assessment reviewed the scientific literature up to 1993 on the use of radiotherapy in the treatment of solid tumours. and estimated the costs associated with radiotherapy It also described the current practise of radiotherapy in Sweden 19
Light influences man both physiological and experiential and different kinds of light sources may have different impact. In a laboratory study the influence of two kinds of light sources, fluorescent tubes and LED on the experience of the surrounding lighting as well as if there were differences in the biological reactions. 42 healthy subjects took part in the study. Two levels of ambient light we
Popular Abstract in Swedish Stjärnors radialhastigheter har i mer än ett sekel haft betydelse för studiet av Vintergatans och stjärnhoparnas kinematik. Radialhastigheten är den hastighet en stjärna, eller ett annat objekt, har längs synlinjen från en given observatör. Hittills har radialhastigheter bestämts med hjälp av spektroskopi, genom att observera spektrallinjer vars vilovåglängder är kända.This work demonstrates the determination of absolute stellar radial velocities from geometrical principles, i.e. using astrometry. Such `astrometric radial velocities' are obtained independently of spectroscopic information. While spectroscopic radial velocities are affected by line shifts from astrophysical processes on the stellar surfaces, by gravitational redshift and various other effects, as
All cellular organisms in aquatic environments are susceptible to virus attack. Viruses are the smallest but most abundant biological entities in freshwaters. This thesis describes interactions between viruses and bacteria in temperate and polar freshwaters with particular emphasis on Arctic and Antarctic aquatic systems. Free virus-like particles in freshwaters are vulnerable and exposed and as p
This thesis describes novel molecular host-parasite interactions with potential significance for the understanding of pathological processes manifested with bacterial infections. Bacterial surface proteins and virulence determinants are shown to mediate the accumulation at the surface of the pathogen of key components of the fibrinolytic and contact phase systems. Plasmin(ogen) binding surface pr
Objective. To study effects on non-cancer mortality of observational weight loss in middle-aged men stratified for body mass index (BMI), taking a wide range of possible confounders into account. Design. Prospective, population based study. Setting. Male population of Malmö, Sweden. Participants. In all 5722 men were screened twice with a mean time interval of 6 years in Malmö, southern Sweden.
1. Salmeterol is a potent, selective and long acting beta 2-adrenoceptor agonist. In vitro, salmeterol exerts 'reassertion' relaxation of airways smooth muscle. Reassertion relaxation refers to the capacity of salmeterol to cause repeated functional antagonism of induced contraction when airway smooth muscle is intermittently exposed to, then washed free from, beta-adrenoceptor antagonists such as
Popular Abstract in Swedish Den viktigaste frågan för många företag handlar om att trygga långsiktig och framgångsrik utveckling. Men hur säkerställer man ett företags framtid när efterfrågan förändras och kostnaderna för produktionen bara ökar? Hur hanterar man teknikutvecklingen och ändrade maktförhållanden i värdekedjan? Svaren på dessa frågor är ofta nytänkande, innovation och en stark kundoriThis thesis explores and describes strategic change towards increased customer orientation and innovation in the Swedish forest and paper packaging industry, an industry which has been subject to calls for new strategic directions for more than two decades. The large-scale and cost-efficient strategy, which has been the industry's hallmark, is in need of a more customer based and innovative emphas
The foundation of this thesis has been to investigate the possibilities of giving Stena Aluminium, a company recycling aluminium, increased control to regulate and steer the risk they are taking when exposing raw material and finished goods. Stena Aluminium wants to minimize the risk of losses on raw material and finished goods when prices change. This is a large problem for instance when raw mate
Purpose:
Identify alternative to the current air transportation routes from supply units in Asia to European customers. The authors strive to provide the department of Supply Flow & Logistics with proposals of how they can reduce their costs and environmental effects connected to transportation. The authors also strive to display and evaluate the risk connected to a change in transp
