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The encapsulation of Pt and Au-based anticancer agents within a protein cage is a promising way to enhance the selectivity of these potential drugs. Here a cytotoxic organometallic compound containing platinum(II) and gold(I) has been encapsulated within a ferritin nanocage (AFt). Inductively plasma coupled mass spectrometry data, collected to evaluate the amount of Pt and Au within the cage, indi
This chapter deals with aqueous two-phase systems, which are formed spontaneously when two polymers are mixed in water as a common solvent. Such phase-separated systems have potential as microencapsulation systems, although the major focus in research has been (bio)separation applications. Added components, such as proteins, large molecules, whole cells, and emulsion droplets, tend to partition pr
Abstract in Undetermined In this paper, we investigate the roles of different diversity mechanisms in two recently proposed six-port MIMO antennas using the effective degree-of-freedom concept. In particular, we confirm that angle and polarization diversities are indeed the dominant diversity mechanisms for the compact antenna that is designed to replicate the characteristics of the ideal co-locat
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapte
The objective of this analysis was to compare three methods of handling HIV-RNA data below the limit of quantification (LOQ) when describing the time-course of antiretroviral drug response using a drug-disease model. Treatment naive Scandinavian HIV-positive patients (n = 242) were randomized to one of three study arms. Two nucleoside reverse transcriptase inhibitors were administrated in combinat
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Introduktion Cancer uppstår när en cell i kroppen börjar dela sig okontrollerat, varmed det sker en onaturlig ansamling av celler ? tumörbildning. Solida tumörer t ex bröst- och prostatacancer är till skillnad från ickesolida tumörer som blodcancer/leukemi ofta dåligt försedda med syre på grund av långa avstånd mellan tumörceller ochNeuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. In earlier studies we have found that hypoxia induces dedifferentiation of neuroblastoma cells, which implies that hypoxia evokes a more aggressive phenotype. Here we employ microarray
We review the history of floristic studies of the parish of Stenbrohult, southern Sweden, where Carl Linnaeus was born in 1707 and spent his summers until 1728. Unfortunately, Carl Linnaeus never made a list of the wild vascular plants at his birthplace, although he mentioned at least 64 species from the parish of Stenbrohult in various manuscripts and books. However, he said that Stenbrohult was
Popular Abstract in Swedish Det kan finnas en risk för att enskilda individer med läpp-käk-gomsplalt (LKG) kan möta problem ur psykosocial synpunkt som en konsekvens av den medfödda avvikelsen. LKG är en av de vanligaste medfödda avvikelserna och sett ut den synpunkten synes det viktigt att närmre undersöka detta antagande. Detta leder till den viktiga frågan om det är LKG-spalten som sådan som ärIn study I, 55 adolescents with cleft lip and palate and 31 adolescents without cleft filled out two questionnaires: the Tennessee Self-Concept Scale to assess self-concept, and the Eysenck Personality Questionnaire Inventory to assess the degree of introversion. In studies II & III, data regarding physical characteristic and general intellectual capacity were obtained from the Swedish Nationa
The relationship between airway responsiveness to bronchoconstrictor- and cough-inducing stimuli has been examined in Ascaris suum-sensitized conscious guinea-pigs. Guinea-pigs were sensitized to Ascaris suum [4000 PNU and 100 mg Al(OH)3 i.p. on days 1 and 7] and then challenged with aerosolized antigen on days 21, 28 and 35. At day 35, antigen-exposure produced an early bronchoconstrictor respons
OBJECTIVE: To compare 3 immunoassays, an immune complex assay, and an application of the polymerase chain reaction (PCR) for the diagnosis of tuberculous meningitis (TBM). MATERIAL: Cerebrospinal fluid (CSF) from 33 patients with TBM and from 34 control patients with infectious and non-infectious CNS diseases was analysed. RESULTS: The antibody immunoassays were either nonspecific or insensitive.
Popular Abstract in Swedish Andningsvägarna kan schematiskt uppdelas i en övre och nedre del där den övre består av näsa, bihålor, (mellanöra) och struphuvud och den nedre av luftstrupe, luftrör samt alveoler. Sjukdomar i andningsvägarna, såsom astma och olika allergiska tillstånd, är vanligt förekommande, men mekanismerna bakom deras uppkomst och utveckling är ofullständigt klarlagda. NeuropeptidThe investigations focus on the neuropeptidepituitary adenylate cyclase-activating peptide and its effects on airway regulation, with emphasis on smooth muscle relaxation and neutrophil activation and migration. In the nasal mucosa, PACAP-containing nerve fibers were localized invascular smooth muscle and close to seromucous glands. In the lung, PACAP-containing nerve fibers were found close to se
Popular Abstract in Swedish Denna avhandling är en sammanläggningsavhandling och består av åtta delarbeten. Delarbetena är publicerade i internationella vetenskapliga tidskrifter, utom delarbete VI-VIII som är föremål för granskning i sådana tidsskrifter inför möjlig publikation. Alla delarbeten representerar studier av bisköldkörteln. Bisköldkörtlarna (parathyroidea) är belägna i anslutning tillThe occurrence and distribution of neurohormonal peptides, neuroendocrine markers and receptors in parathyroid nerve fibers and endocrine cells are described, using immunocytochemistry, in situ hybridization, image analysis and reverse transcriptase polymerase chain reaction. Immunocytochemical studies revealed that parathyroid glands of chicken, rat, guinea-pig, cat, dog and sheep contained adren
In this paper, I discuss the following questions: - What kind of implication arises from an argument wh-question? - What kind of implication arises from a clefted argument wh-question in Swedish? - Is there any difference in Swedish between clefted and non-clefted argument wh-questions with regard to the implications of existence they give rise to? I argue that both types of argument wh-questi
Populärvetenskaplig sammanfattning Oxidativa modifieringar av S100A9 S100A9 är ett protein i kroppen som får en förändrad struktur och funktion när det reagerar med syre. De strukturella förändringarna kallas oxidativa modiferingar. För att förstå processen skulle man kunna jämföra S100A9 med järn. När järn kommer i kontakt med syre får det en rödaktig färg och strukturen går från att vara stark tThe aim of this project was to examine how S100A9 binding to target molecules was affected by structural modifications with oxidizing agent in vitro. S100A9 was cultivated, purified and oxidative modifications were induced. The oxidative modifications where characterized with tryptohan fluorescence, Surface Plasmon Resonance technique (SPR) and MALDITOF-MS. To get access to protein to study recomb
Issues related to attribution of profits already exist in the traditional economic framework and are of a different nature, however these issues seem to become more bothersome in transactions conducted in e-commerce context, with an electronic economy. The matter is similar to the traditional economic problems in regard to transfer pricing adjustments; however these issues are much more complex du
