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Popular Abstract in Swedish Den medicinska termen sepsis, "blodförgiftning" orsakas av bakterier i blodet. Symptombilden kan variera från tämligen lindriga förlopp till septisk shock, som har en hög dödlighet. Vid sepsis och septisk shock aktiveras olika kroppsegna system såsom koagulations- och komplementsystemet. Många mekanismer medieras av så kallade cytokiner. Dessa budbärarmolekyler byggs upPurified bacterial cell wall components peptidoglycan and teichoic acid were isolated from staphylococcal species S. aureus and/or S. epidermidis and tested for their ability to induce cytokine release from plastic-adherent human monocytes. Both cell wall components dose-dependently induced TNF-alpha, interleukin-1beta, and interleukin-6 release, peptidoglycan being more potent than teichoic acid.

Popular Abstract in Swedish Pyrimidiner är DNA-byggstenar som är essentiella för cellens överlevnad och delning. I mänskliga celler finns pyrimidiner att tillgå antingen genom återupptag eller genom biosyntes (nysyntes). Biosyntesen av pyrimidiner sker i flera steg och i ett av dem spelar enzymet Dihydroorotat dehydrogenas (DHODH) en avgörande roll genom att katalysera en oxidationsreaktion. När cIn the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. Potent inhibitors were identified within three classe

This thesis considers numerical simulations of high energy particle collisions, and improvements in the description of multiple collimated jets of hadrons in collision events in particular. In the event simulation software called event generators, the structure of multi-jet events is determined through an interplay of the input calculation, parton showers and phenomenological hadronisation models.

Neutrino physics is one of the fastest growing topic in phenomenological high energy physics. Neutrinos are elementary neutral particles and participate only in the weak interactions. For this reason it is very difficult to detect them experimentally. Nevertheless, much experimental progress has been obtained in the recent years. In particular our knowledge of the neutrino masses and mixing angles

This paper describes the potential help that the interactive desktop concept can bring to the execution of embodiment design tasks. The presented project is still in its infancy. The research framework is the following: once a product concept has been approved, the mechanical design engineer develops the product architecture and product part (also called embodiment design). Sketches at that level

We study the relationship between the structural transformation of the economy and theincome distribution, focusing on the case of Sweden from 1870 to 1970, with extra attentionpaid to the 1870–1950 period, for which we produce extensive new data. Average incomeincreased fivefold between 1870 and 1950, and the share employed in agriculture declinedfrom 72 to 23 per cent. To study the evolution of

This chapter addresses the difference between the intentions of the law and its application by using mobile telephony infrastructure development in Sweden as a case. Three possible pitfalls for policy management in general are concluded and analyzed. The first pitfall deals with legal complexity, which may be a result of piecemeal changes to the governing legal bodies over a longer time and is her

The efficacy of integrating open access geospatial data to produce habitat suitability maps for the corn bunting (Miliaria calandra) was investigated. Landsat Enhanced Thematic Mapper Plus (ETM+), Shuttle Radar Topography Mission (SRTM) and Corine (Coordination of Information on the Environment) land cover data for the year 2000 (CLC2000) were processed to extract explanatory variables and divided

Human galectins have functionally divergent roles, although most of the members of the galectin family bind weakly to the simple disaccharide lactose (Galss1-4Glc). To assess galectin-glycan interactions in more detail, we explored the binding of several important galectins (Gal-1, Gal-2, and Gal-3) on a glycan microarray containing hundreds of structurally diverse glycans. All three galectins exh

Popular Abstract in Swedish Avhandlingen, som består av tre delar, handlar om olika metoder för att undersöka algebraiska begrepp med hjälp av datorberäkningar. I första delen visar vi att en viss Liealgebra inte, till skillnad från många andra Liealgebror av liknande typ, kan brytas ned i vinkelräta komponenter av en speciellt enkel typ. Andra delen handlar om vilka polynom som kan bildas genomThis thesis consists of a collection of articles all using and/or developing algorithmic methods for the investigation of different algebraic structures. Part A concerns orthogonal decompositions of simple Lie algebras. The main result of this part is that the symplectic Lie algebra C3 has no orthogonal decomposition of so called monomial type. This was achieved by developing an algorithm for fin

Dendroclimatological sampling of Scots pine (Pinus sylvestris L.) has been made in the province of Jamtland, in the west-central Scandinavian mountains, since the 1970s. The tree-ring width (TRW) chronology spans several thousand years and has been used to reconstruct June August temperatures back to 1632 BC. A maximum latewood density (MXD) dataset, covering the period AD 1107-1827 (with gap 1292

Abstract in French Afin d’évaluer l’importance relative de la reproduction sexuelle et végétative dans les populations d’une plante de prairie, l’Hieracium pilosella L., les auteurs ont utilisé des marqueurs allozymiques permettant d’en identifier les clones. Les études conduites aux champs, sur les populations d’espèces de plantes clonales, ont souvent fait état de recrutement absent ou négligeabAllozyme markers were used to fingerprint clones of the grassland plant Hieracium pilosella and, by inference, to estimate the relative importance of sexual and vegetative reproduction in a population. Field studies in populations of clonal plant species have often reported negligible or absent recruitment from seed. In contrast, studies of genetic markers have found substantial clonal diversity i

The dissertation aims to develop an understanding of the outcomes and limitations of formal and informal control of the Swedish state, and of the positions and strategies of the social agents involved in this field. The dissertation contributes with new perspectives on controls directed at the state, comparing various control organs (the Parliamentary Ombudsman, the Chancellor of Justice, the UnitThe dissertation aims to develop an understanding of the outcomes and limitations of formal and informal control of the Swedish state, and of the positions and strategies of the social agents involved in this field. The dissertation contributes with new perspectives on controls directed at the state, comparing various control organs (the Parliamentary Ombudsman, the Chancellor of Justice, the Unit

Background: In a global perspective, bacterial infections are still a major cause of morbidity and mortality; therefore, effective antibiotics are needed. However, the emergence of antibiotic resistance due to irrational use has now become a serious public health problem. Hence, the objective of this study was to analyse the association of regulatory aspects with antibiotic consumption. Methods: A

Popular Abstract in Swedish Inom området datorgrafik undersöker man hur virtuella scener kan omvandlas till verklighetstrogna bilder. För interaktiva miljöer, som exempelvis datorspel, måste en ny bild vara genererad och klar att visas på skärmen mellan 30-60 gånger i sekunden för att upplevelsen ska kännas responsiv och för att rörelser ska flyta på ett naturligt sätt. För att datorn ska hinna meThe field of computer graphics refers to the use of computers to generate realistic-looking images from virtual scenes. Graphics processing units use an algorithm known as rasterization to compute images of scenes viewed from a virtual camera. The commonly used pinhole camera model does not account for the imperfections that stem from the physical limitations in real-world cameras. This includes,

BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women

Objectives. To record the occurrence of well-differentiated bladder carcinoma reported as T1 G1 to the Swedish Urinary Bladder Cancer Registry, to review the staging and grading of the carcinomas and to scrutinize the validity of the data on T1 G1 tumours reported to the registry during the period 1997-2000. Material and methods. The primary histopathological diagnoses of 98 cases of well-differen

Each of 102 Nordic routine clinical biochemistry laboratories collected blood samples from at least 25 healthy reference individuals evenly distributed for gender and age, and analysed 25 of the most commonly requested serum/plasma components from each reference individual. A reference material ( control) consisting of a fresh frozen liquid pool of serum with values traceable to reference methods