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Popular Abstract in Swedish Hypertriglyceridemi (förhöjd plasma triglycerid(TG)nivå) är en riskfaktor för hjärt- kärlsjukdom. Det har föreslagits att relationen mellan fettintag och arterioskleros orsakas av vad som utspelar sig timmarna efter måltid. TG i chylomikronerna (CM) , dvs de fettrika partiklar som transporterar kostens fett via lymfan till blodbanan hydrolyseras då av lipoproteinlipas, 1. During incubation of platelets with 3H-arachidonic acid (20:4, n-6) and 14C-cholesterol doubly labelled and colloidal gold labelled chylomicrons (CMs) and chylomicron remnants (CMRs) CMs were taken up more efficiently than CMRs. Addition of unlabelled CMs, VLDLs, LDLs and HDLs decreased the uptake of labelled CMs. Electron microscopic studies demonstrated an accumulation of CM-Au's both in the

Popular Abstract in Swedish I denna avhandling undersöktes förekomsten och regleringen av neuropeptiden PACAP (pituitary adenylate cyclase-activating polypeptide) i det sensoriska nervsystemet hos råtta och mus och hur de normala nivåerna av PACAP ändrades vid olika betingelser som t.ex. nervavskärning och lokal inflammation. Dessutom undersöktes PACAPs roll vid smärta genom att studera om smärtsvThe data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. PACAP is one of the excitatory neuropeptides expressed in small sized DRG ne

Today’s debate about the EC and its future can be grouped along two main lines. On the one side are those who hold that the EC is a grouping of sovereign states for the purposes of international cooperation. On the other side are those who maintain that the EC is a new political society that unites the citizens of Europe in a new political and legal community where the question of the sovereignty

Background: Training of neuromuscular control has become increasingly important and plays a major role in rehabilitation of subjects with an injury to the anterior cruciate ligament (ACL). Little is known, however, of the influence of this training on knee stiffness during loading. Increased knee stiffness occurs as a loading strategy of ACL-injured subjects and is associated with increased joint

Coronary artery diseases (CAD) are main causes of morbidity and hospitalisation in western countries and CAD patients are at considerable risk of suffering further cardiac events. The development and evaluation of secondary prevention programmes therefore an important task. This thesis includes investigations on CAD patients admitted to a secondary prevention programme at Malmö University Hospital

We introduced a reporter gene system into Pichia stipitis using the gene for the artificial green fluorescent protein (GFP), variant yEGFP. This system was used to analyse hypoxia-dependent PsADH2 regulation. Reporter gene activity was only found under oxygen limitation on a fermentable carbon source. The promoter was not induced by oxygen limitation in the Crabtree-positive yeast Saccharomyces ce

The objective of this study was the investigation of the maximal potential donor pool and causes of non-realized organ donation. On-site retrospective medical-record review was performed for all cases of patient death (n=1608) occurring in 1999 at 34 (83% of all) intensive care units (ICUs) in the region of the transplant center in Prague, Czech Republic. Two hundred and eighty-eight (18%) patient

Propofol, an intravenous anaesthetic, has been shown to interact with the beta -subunit of the gamma -amino butyric acid(A) (GABA(A) ) receptor and also to cause changes in [Ca2+ ](i) . The GABA(A) receptor, a suggested target for anaesthetics, is known to be regulated by kinases. We have investigated if tyrosine kinase is involved in the intracellular signal system used by propofol to cause anaes

Postoperative pain after total knee arthroplasty (TKA) is severe, and achieving adequate analgesia remains a clinical challenge. We tested the hypothesis that, in patients having unilateral TKA under intrathecal (IT) anesthesia, the addition of a femoral nerve block would provide superior analgesia when compared with IT morphine and demonstrate fewer adverse side effects. In a single-blinded and c

We studied islet function in mice with beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor (HNF)-1alpha. At age 2-3 months, anesthetized transgenic and wild-type male mice underwent an intravenous glucose (1 g/kg) tolerance test (IVGTT). It was found that transgenic mice had an abolished insulin response in association with severe glucose intolerance. In other

Thylakoids from the green alga, Dunaliella salina, were fragmented by sonication and the appressed grasna membranes separated from stroma lamellae by partitioning in aqueous two-phase systems. The concentration and antenna size of Photosystem I in the two membrane domains were determined for cultures grown at three different light intensities. Although the antenna size of both PS is decreased with

We have previously reported suggestive linkage to chromosome 5p13-q13 in type 1 diabetic families. ISL1, a transcription factor involved in pancreas development, maps to this region. Sequencing of the ISL1 gene in patients and control subjects identified seven single nucleotide polymorphisms (SNPs) and one microsatellite in noncoding regions. Four haplotypes formed by six of these SNPs and one mic

Background: Impaction grafting in hip revision surgery is widely used but studies with mid- and long-term follow-up are scarce. Patients, methods and results A 5-year radiostereometric (RSA) follow-up of 15 hip revisions with the Exeter stem, morselized impacted allograft bone and cement revealed that 3 stems had not migrated between 2 and 5 years after revision, 11 stems had migrated to a minor

The mechanisms underlying longitudinal displacements of the arterial wall, that is, displacements of the wall layers along the artery, and the resulting intramural shear strain remain largely unknown. We have already found that these displacements undergo profound changes in response to catecholamines. Wall shear stress, closely related to wall shear rate, represents the viscous drag exerted on th

The mechanisms that increase cardiovascular risk in individuals born small for gestational age (SGA) are not well understood. Telomere shortening has been suggested to be a predictor of disease onset. Our aim was to determine whether impaired intrauterine growth is associated with early signs of vascular aging and whether telomere length could be a biomarker of this pathway.