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Introduction: Endotoxemia developing during cardiosurgery as elevated endotoxin concentrations in patient's serum may prevail over 24 h after operation. A major reason is thought to be increased gut permeability resulting in endotoxin and bacterial leakage. In this study we aimed to measure endotoxin levels on samples obtained during and after cardiovascular procedures and compare them with clinic
The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I polymo
Samples from the Danian were prepared for study of coccoliths, on one hand with Light Microscopy, on the other hand with Scanning Electron Microscopy to test the different advantages and disadvantages of these methods. Light Microscopy studies can be used for quantitative investigations and Scanning Electron Microscopy studies for quantitative and qualitative investigations of coccoliths. Scanning
The current study examines the effects of a computerised Working Memory (WM) intervention in elementary school children when training in groups of various sizes. It further examines the effects of noise during the performance of WM tasks. The children included were 7 - 9 years old and were randomly assigned to control and training groups based on Raven's scores. Results showed an improvement o
The arguments put forward in the debate on Turkey's bid for EU membership are many and diverse. The aim of this thesis is, by using the methodological framework of constructivst comparative politics and political reasoning, to systematically structure the arguments. Officially the question of whether or not Turkey will become a member of the EU depends upon the developments internally in the c
The initiative to unite the economies of the Americas into a Free Trade Area of the Americas (FTAA) is increasingly threatening the survival of the indigenous people making them coalesce into transnational coalitions with people throughout the region. The aim of this thesis is to examine how the threats posed by the proposed FTAA and the opportunities of transnational activism opposing it has infl
The WTO Doha Round illustrates the conflict of unequal distribution of influence between the developing and developed countries in multilateral trade negotiations and the changing of power relations over time. This thesis analyzes and explains how the developing countries have influenced the multilateral trade negotiations of the WTO Doha Round using a model of analysis testing and comparing reali
In disadvantaged areas of Eastern Sri Lanka, girls tend to be more vulnerable to both voluntary and forced recruitment by the Liberation Tigers of Tamil Eelam (LTTE). This thesis focused on how a group of recently released young female ex combatants reintegrated into their community. This was done through a case study of girls in a vocational training program in Eastern Sri Lanka, who had been rel
Different approaches have been used for translation of the EAT–Lancet reference diet into dietary scores that can be used to assess health and environmental impact. Our aim was to compare the different EAT–Lancet diet scores, and to estimate their associations with all-cause mortality, stroke incidence, and greenhouse gas emissions. We did a systematic review (PROSPERO, CRD42021286597) to identify
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine (T4) hormones depends on the conformation, iodination and post-translational modification of TG. Although st
Type 2 diabetes (T2D) has a complex etiology which is not yet fully elucidated. The identification of gene perturbations and hub genes of T2D may deepen our understanding of its genetic basis. We aimed to identify highly perturbed genes and hub genes associated with T2D via an extensive bioinformatics analytic workflow consisting of five steps: systematic review of Gene Expression Omnibus and asso
Background: Cognitive deficits such as difficulties with attention, memory, and executive functions are frequently reported during remission from depression and relates to adverse functioning in daily life and risk of relapse. There is therefore a need for interventions targeting cognitive deficits after depression. However, few randomized controlled trials have investigated the efficacy of interv
Background: Artificial intelligence (AI) systems can potentially aid the diagnostic pathway of prostate cancer by alleviating the increasing workload, preventing overdiagnosis, and reducing the dependence on experienced radiologists. We aimed to investigate the performance of AI systems at detecting clinically significant prostate cancer on MRI in comparison with radiologists using the Prostate Im
Pharmaceutical companies spend hundreds of millions of pounds on marketing/R&D-related payments annually to healthcare organisations and healthcare professionals. UK pharmaceutical industry self-regulatory bodies require member companies who sign up to their code of conduct to publish details of their payments. They are also required to publish the methodologies underlying these payments, name
Objective To elucidate experiences and coping strategies among adults in the surveillance of indeterminate pulmonary nodules detected with CT in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS).Design A qualitative study of conventional content analysis.Settings The study was conducted at a university hospital in a southern region of Sweden. The SCAPIS setting is similar to the
A new 130 to 140 Ma mafic dyke swarm, is identified in western South Africa. It consists of the previously undated Cederberg dyke swarm (CDS), for which we report U-Pb ID-TIMS baddeleyite ages of 131.4 ± 4.5 Ma (Knersvlake subswarm) and 133.0 ± 1.5 Ma (Doring-Tanqua subswarm).40Ar/39Ar dates on these two samples and two additional dates of the Doring – Tanqua subswarm cluster between 128.5 ± 1.4 M
