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Mammalian cells are frequently under stress leading to DNA damage because of UV exposure, ionizing radiation or genotoxic chemicals. Cells have evolved a DNA damage response (DDR) mechanism to ensure survival and pass on the correct genetic information to the next generation. MITF is a melanocyte-specific transcription factor. It has been shown to accumulate in the vicinity of DNA damage and its e

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Det är statens suveräna rätt att reglera utlänningars närvaro inom dess territorium. Denna rätt är däremot inte utan begränsningar. Artikel 1 i protokoll nr. 7 till Europeiska konventionen om skydd för de mänskliga rättigheterna säkerställer rättssäkerhetsgarantier i samband med utvisningen av utlänningar. Dessa rättssäkerhetsgarantier måste tillgodoses vid utvisningsförfarandet i de medlemsstaterIt is the sovereign prerogative of the state to regulate the presence of aliens within its territory. This right, however, is not without limits. Article 1 of Protocol No. 7 to the European Convention on Human Rights ensures procedural safeguards relating to the expulsion of aliens. These safeguards must be considered in expulsion proceedings by those Member States having ratified the protocol.

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This thesis exists within the debate of sustainable environmental management, examining the potential of rights of nature in overcoming problems caused by the current neoliberal conservation paradigm such as inequalities in power, lack in indigenous inclusion, as well as using contextually inappropriate approaches. In examining this a qualitative comparative case study research design is applied o

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Five years into the present peacebuilding cycle in Colombia, violence is increasing again. In the Putumayo department, social-ecological conflicts between the state, armed groups and local communities persist. Social leaders, often representing local communities, are targets of violent actions and represent an extremely vulnerable group. In the Putumayo, at least 67 social leaders defending human

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The United States is the only OECD country to not provide universal health coverage to its citizens. While majority of the population is able to obtain insurance through employer-sponsored plans, many low-income adults fall victim to the ‘coverage gap’ – earning too much to qualify for state-funded social programs, in jobs that fail to provide a viable alternative. The central aim of the Affordabl

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Uppsatsen behandlar hur tre svenska byggföretag (Skanska, NCC och PEAB) har valt att internationalisera/etablering sig på den polska byggmarknaden. Eftersom byggföretags internationalisering kan tänkas se annorlunda ut än ett produktionsföretag finner vi detta som ett intressant ämne att studera vidare. Detta sker först via en genomgång av möjlig teoretisk data där vi granskat fyra olika internati

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Purpose: The purpose of this study is to improve the material supply to assembly stations at Nedermans and identify parameters and principles that determine if the components should be stored at the assembly station or in the warehouse. The improvement should reduce the floor space used for assembly, increase the assembly utilization rate and reduce waste of time in the material handling.
Meth

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This thesis problematizes the exclusion of disabled people in society and their rights. The emphasis of the research is on persons with severe or/ and multiple disabilities who tend not to have capabilities to politically interact with society. They are one of the most marginalized groups among disabled people in numerous aspects while most of them are already excluded in society. This research es

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Syftet med studien var att undersöka polyamorösas upplevelse av terapi med fokus på bemötande, den terapeutiska relationen och klienternas öppenhet med att berätta om sina relationsätt. Semi-strukturerade intervjuer genomfördes med sex deltagare som samtliga är polyamorösa och har erfarenhet av psykoterapi. Studien har en hermeneutisk fenomenologisk vetenskapsteoretisk ansats och materialet analysThis study aims to investigate polyamorous individuals’ experiences of psychotherapy. We inquired whether attitudes towards polyamory may influence the therapeutic relationship, and clients’ experiences of being open about their polyamorous lifestyle. Semi-structured interviews were conducted with six participants who are polyamorous and have experience of psychotherapy. The study is based on a he

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Postpartum depression (PPD) affects about 13% of all women giving birth and is described as a devastating disorder. Yet, the majority of women suffering from PPD do not seek professional help. Insecure attachment is shown to be a significant help-seeking barrier for women with PPD; however as research thus far has focused on help-seeking populations it is still unknown how different attachment sty

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European strategic autonomy has been a fluctuating discussion since the end of the Second World War. It has primarily been the project of France, but has mostly failed to materialise. This is partly due to other European states’ worry that such a project would become an extension of French national interests. Some of the strongest opponents of an exclusive European defence cooperation have been sm

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The plausibility threshold started, and is still, developing through the case law of the EPO. It is used as a tool against speculative patents, as the claimed technical effect of the invention must be made plausible. The plausibility threshold is foremost being used at the EPO in relation to the requirement of an inventive step under Article 56 EPC and the requirement of sufficiency of disclosure

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Syftet med denna studie är att ta reda på de eventuella folkmusikaliska influenserna i svensk respektive grekisk populärmusik och göra en jämförelse mellan de båda. Syftet är också att finna likheter och skillnader i hur svenska respektive grekiska folkmusikstudenter resonerar kring folkmusikaliska influenser i populärmusik för att belysa ämnet ur olika perspektiv Svensk och grekisk populärmusik hTitle: Folk musical influences in Swedish and Greek popular music - a comparative study. What folk music influences Swedish and Greek folk music students can find in popular music and how they reason about them. Author: Michael Sideridis The purpose of this study is to determine the possible influences of folk music in Swedish and Greek popular music and make a comparison between the two. It also

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Eftersom det inte finns så mycket tidigare forskning bedriven inom ämnesområdet lyx och premium vill vi skapa en ökad förståelse för vad detta egentligen är och vilka utmärkande särdrag som karaktäriserar dessa varumärken. Dessutom finner vi forskningen än mer outvecklad och inte bedriven i någon större omfattning utifrån ett företagsperspektiv hur signifikanta lyxens egenskaper är i dessa varumär

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Introduction: Patients addicted to alcohol or drug often have additional unhealthy lifestyles, adding to the high mortality and morbidity in this patient group. Therefore, it is important to consider lifestyle interventions as part of the usual addiction treatment. Objective: The aim was to identify predictors of successful changes in lifestyle risk factors among patients in treatment for alcohol

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BackgroundResearch involving current and future generations of older adults in the design of smart home technology (SHT) is scarce. In this study, current and future generations of older adults, professionals, and researchers together sought to identify user needs and aspirations for and related to SHT. The aim was to co-produce prioritized ideas for SHT solutions to support engagement in everyday

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Introduction: The co-occurrence of lupus nephritis (LN) and chronic kidney disease (CKD) is associated with an excess risk of infection. However, it remains unknown whether the infection risk differs between LN with moderate and advanced CKD (LN-CKD) and other CKD etiologies. Methods: Using data from the Swedish Renal registry 2006-2021, we identified 14,128 patients (median age 68 years, 64% men,

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A measurement of off-shell Higgs boson production in the H∗ → ZZ → 4ℓ decay channel is presented. The measurement uses 140 fb−1 of proton–proton collisions at √s = 13 TeV collected by the ATLAS detector at the Large Hadron Collider and supersedes the previous result in this decay channel using the same dataset. The data analysis is performed using a neural simulation-based inference method, which

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In this thesis, computationally efficient statistical models for large spatial environmental data sets are constructed. In the first part of the thesis, a method for estimating spatially dependent temporal trends is developed. A space-varying regression model, where the regression coefficients for the spatial locations are dependent, is used. The spatial dependence structure is specified by a Ga