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Carbon-based materials are highly sought after due to their superior properties, making them valuable for high-performance applications. However, most carbon-based materials are derived from fossil sources, and their synthesis often involves hazardous chemicals. Therefore, it is essential to develop sustainable methods for synthesising these materials from renewable resources, using fewer solvents
Background: Chronic low-grade inflammation is a well-known risk factor for coronary heart disease (CHD) and future cardiovascular events. Anti-inflammatory therapy can reduce the risk of ischemic cardiovascular disease (CVD) events following myocardial infarction (MI). However, it remains unknown to what extent inflammation at the time of an acute event predicts long-term outcomes. We explored whe
Background: Despite progress in the treatment of asthma, there is an unmet need for additional therapeutic strategies, not least to avoid side-effects of corticosteroids. The enzyme MutT homolog 1 (MTH1) hydrolyzes oxidized purines and prevents their insertion to DNA. Small molecule inhibition of MTH1 has shown promising therapeutic effects in both cancer and inflammatory conditions. In this study
Objective: To evaluate the fecal metabolome in patients with early systemic sclerosis (SSc) compared with unaffected controls and to determine if altered metabolites are associated with specific bacterial genera in patients with early SSc. Methods: Stool samples and clinical data were collected from 106 patients with early SSc and 79 unaffected control patients. Targeted metabolomics was performed
Aims To study the prevalence of masked uncontrolled hypertension (MUCH) in patients recently hospitalized for myocardial infarction, and to develop machine learning-based prediction models identifying MUCH. Methods and results Ambulatory blood pressure measurement (ABPM) was performed in 99 patients following hospitalization for a myocardial infarction. Sixty-two clinical variables were eligible f
In this paper we present the first investigation of the C–N coupling reaction between N-tosylhydrazones including O-peracylated 2,6-anhydro-aldose tosylhydrazones and 1H-1,2,3-triazoles under catalyst-free conditions. This transformation is characterized by relatively mild thermal conditions, high regioselectivity in favor of 2,4-disubstituted 2H-1,2,3-triazoles and broad functional group tolera
Research suggests that individuals often overlook beneficial subtractive strategies when solving problems. Subtractive strategies, which include reducing demand for goods and services (e.g., reducing car use), have a high climate mitigation potential. Yet, these may be systematically overlooked in favor of additive strategies like adopting new technologies (e.g., buying an electric car). This Regi
Offering supports for young adults with mental health problems in their educational and vocational pursuits promotes well-being, social inclusion, and self-sufficiency. It is therefore important that welfare actors offer services to this group. However, in Sweden, with a tradition of local self-governance and municipal autonomy, decisions regarding which services to offer may depend on perceptions
Haploblocks are regions of the genome that coalesce to an ancestor as a single unit. Differentiated haplotypes in these regions can result from the accumulation of mutational differences in low-recombination chromosomal regions, especially when selective sweeps occur within geographically structured populations. We introduce a method to identify large well-differentiated haploblock regions (LHBRs)
Introduction: Residual cognitive deficits are commonly reported by individuals in remission from depression, often affecting daily life functioning and mental health. To provide tailored and personalized cognitive enhancement interventions for this population, there is a need for a better understanding of the characteristics of those who benefit from such interventions. Therefore, this study aimed
Objective: To evaluate the causal effect of genetically predicted serum urate (SU) levels on the risk of overall and major site-specific cancers in individuals of European ancestry, using Mendelian randomization (MR) analysis. Method: Data from two population-based cohorts from southern Sweden, the Malmö Diet and Cancer Study (MDCS) and Malmö Preventive Project (MPP), and summary-statistics data f
Objectives Early detection of neurosensory injury among workers exposed to hand-arm vibration is crucial. The aim of our study was to evaluate the diagnostic test performance of clinical point-of-care testing using a tuning fork and temperature rollers in relation to vibrotactile and thermal quantitative sensory testing. Methods We recruited 225 vibration-exposed workers who underwent clinical poi
Understanding the structure of metal-ligand complexes is essential for catalyst design, materials development, and biochemical modeling. Metal carbonyls are especially relevant due to their diverse structures and electronic features. Here, we benchmarked seventeen density functionals (B3LYP, BP86, CAM–B3LYP, M06, M06L, PBE, PBE0, r2SCAN, r2SCAN–3c, revPBE, revTPSS, RPBE, TPSS, TPSS0, TPSSh, (Formu
OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of acupuncture for the treatment of infantile colic.
The Paris Agreement necessitates global net-zero emissions by mid-century, including steel industry emissions that currently amount to about 7% of global energy system emissions. In this article we review the literature on steel decarbonization. Steel industry emission mitigation measures include reduced demand through materials efficiency, increased high-quality recycling, and decarbonization of
This paper presents an integrated conodont biostratigraphy and carbon isotope chemostratigraphy for the Cambrian-Ordovician transition in western Zhejiang, southeast China. Eight conodont zones can be recognized, in ascending order the Westergaardodina cf. calix-Prooneotodus rotundatus, Proconodontus, Eoconodontus, Cordylodus proavus, Cordylodus intermedius, Cordylodus lindstromi, Cordylodus angul
Background: Employment rates are lower in adults with cerebral palsy (CP). Even though reduced manual ability is associated with limitations in daily activities, it is unclear whether employment rates are associated with manual ability in adults with CP. Objective: To analyze regular employment and employment rates (hours/week) in adults with CP and estimate their associations with manual ability
This chapter focuses on how to apply salutogenesis in practice in the context of health care, especially when designing interventions. The foundation for implementation is to understand and apply the core principles of salutogenesis and health promotion, hereby building capacity and strength in all involved, i.e.: the patients, participants, health professionals and relatives. The key salutogenic
Bakgrund: Hemlöshet utgör en komplex global samhällsutmaning. Individuella, politiska och sociokulturella faktorer begränsar hemlösa personers möjligheter att utöva sin rätt till aktivitet och hälsa i vardagen. Internationella studier indikerar att aktivitetsbaserade åtgärder kan vara gynnsamma för målgruppen, men mer samlad kunskap behövs för att stödja framtida studier som undersöker hur svenskaBackground: Homelessness constitutes a complex global societal challenge. Individual, political and socio-cultural factors limit homeless persons from exercising their right to activity and health in everyday life. International studies show that the use of occupation-based interventions may benefit the target group. Further evidence is needed to inform future studies investigating how Swedish occ
