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BACKGROUND: High-risk neuroblastoma (HR-NB) is associated with therapy-resistant relapse, and novel therapeutic strategies are needed. GSPT1 is a GTPase involved in protein translation whose disruption may offer therapeutic potential in translation-dependent cancers.METHODS: GSPT1 expression was assessed in publicly available clinical data and tissue microarrays. GSPT1-degrading molecular glues we

Nature-based Solutions (NBS) are recognized as key actions for achieving sustainable and resilient development. They are being implemented in a variety of fields, such as urban planning, and offer a wide range of social, environmental, and economic benefits. While there has been a significant increase in the number of NBS practices in recent years, there remains a notable imbalance, with a bias to

Carbon Black (CB), graphene, and nanodiamonds represent three classes of manufactured carbonaceous nanoparticles consisting almost exclusively of insoluble material. Particle-related Reactive Oxygen Species (ROS) have been linked to in vivo and in vitro toxicity and determining particle ROS activity is an efficient way of estimating nanomaterial toxicity and assist in the safe-by-design developmen

IMPORTANCE: Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants' anxiety and pain. These deficiencies impair the planning and implementation of potent

Friendship is a common and complex social bond. Among friendship practices yet to be fully understood are group- versus dyadic-oriented friendship styles, or whether people socialize with one versus multiple friends at a time. We report two studies comparing friendship styles and relational mobility among 1674 young adults (18–35 years old) in Japan and the United Kingdom. Respondents from both co

Randomised controlled trial (RCT) protocols contain essential details needed to understand and evaluate the trial's planned aims, design, data collection methods, monitoring, data analysis, and participants' safety. However, key information is often omitted from paediatric RCT protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmenta

BACKGROUND: TF (transcription factor) Prdm16 (positive regulatory domain-containing protein 16) regulates hematopoietic and neuronal stem cell homeostasis, adipose differentiation, and cardiac development. Its role in the circulatory system extends beyond the heart, as Prdm16 loss in arterial endothelial cells (ECs) impairs arterial reperfusion of ischemic mouse limbs due to endothelial dysfunctio

The integration of proton exchange membrane fuel cells (PEMFCs) in heavy-duty vehicles and other demanding applications, such as aviation, would be simplified if the stacks could operate above 100 °C instead of the traditional low temperature (LT, up to 80 °C), thereby allowing a reduction in cooling system in size and power. This review offers a comprehensive compilation of experimental studies r

Aim: This study evaluates the health effects of plant-based dairy alternatives in healthy individuals and those with Inflammatory Bowel Disease (IBD). Specifically, it investigates whether replacing one daily meal with a plant-based alternative has a positive impact on intestinal microbiota composition and gut health. It also investigates whether the effect of probiotic bacteria in yogurt depends

Comparison of ROS production of individual particle components from traffic-related sources can inform new health policies and emissions legislation. This work aims to quantify acellular ROS production and oxidative potential (OP) of such individual particle components from combustion, brake, tire, and road wear. Particle characteristics are probed to identify source-specific markers and improve t

CT-based radiostereometric analysis (CT-RSA) is a method of measuring implant micromotion using low-dose CT scans. We evaluated the precision, accuracy, and observer reliability of CT-RSA for measuring femoral stem translation in THA in vitro. A cementless femoral stem was implanted in a synthetic femur mounted on a calibrated micrometer platform. Controlled translations were applied along each or

Most European Union (EU) residents live in areas where outdoor air pollution levels exceed the 2021 World Health Organization (WHO) air quality guidelines for fine particles and nitrogen dioxide. Outdoor air pollution is classified as carcinogenic to humans, and both outdoor and indoor air contain established human carcinogens, including diesel exhaust particulates, benzo(a)pyrene [B(A)P] and benz

A resolved optical image of a gamma-ray emitter would be of enormous scientific interest. For gamma-ray sources associated with interacting stars (colliding winds or novae), stellar intensity interferometry (SII), envisioned as a second observing mode at the Cherenkov Telescope Array Observatory (CTAO), could yield images of the systems in visible light. Recent radius measurements of massive stars

Carbon Black (CB), graphene, and nanodiamond are distinct carbonaceous insoluble nanoparticles. Reactive Oxygen Species (ROS) associated with these particles play a significant role in both in vivo and in vitro toxicity evaluations. Accurate assessment of ROS activity is relevant for toxicity screening and in ensuring safe working environments as well as guiding the innovation by safe-and-sustaina

Occupational exposure to cancer-causing agents is a major, yet preventable, contributor to cancer in Europe and globally. In the European Union (EU), cancer is responsible for nearly half of all work-related deaths, underscoring the critical need for prevention measures. Effective strategies typically involve regulatory and workplace measures aimed at reducing or eliminating exposure risks. Raisin

The European Code Against Cancer (ECAC) provides evidence-based recommendations to help individuals reduce their cancer risk. For the 5th edition (ECAC5), recommendations on ultraviolet radiation (UVR) and indoor radon exposures were updated, and complementary recommendations for policymakers were introduced. UVR and radon are classified as carcinogenic to humans (group 1 carcinogens) in the Inter

Conventional traceability systems without real-time information transmission are susceptible to tampering. In contrast, blockchain and artificial intelligence (AI)-enabled traceability models offer transparency and accountability, given their decentralized nature and immutability. This research conceptualizes and develops a hybrid blockchain and AI-enabled traceability (prototype) model and implem