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Nucleoside analogues (NA) are prodrugs that are phosphorylated by deoxyribonucleoside kinases (dNKs) as the first step towards a compound toxic to the cell. During the last 20 years, research around dNKs has gone into new organisms other than mammals and viruses. Newly discovered dNKs have been tested as enzymes for suicide gene therapy. The tomato thymidine kinase 1 (ToTK1) is a dNK that has been
A diagnosis of malignant hyperthermia (MH) can be determined by performing an in vitro (muscle) contracture test (IVCT) or by identifying a known MH causative mutation in the ryanodine receptor 1 gene (RYR1). Genetic diagnosis has an advantage over IVCT because it is less invasive. Direct sequencing of the very large RYR1 coding region (15.117 bases) is a laborious and expensive task. In this stud
This issue of Leadership marks our first full year as Co-Editors-in-Chief. As we highlighted in our introductory editorial (Edwards and Schedlitzki, 2023) we see our role as striving to develop the community of the journal in its endeavour to be a key, critical and contemporary voice for leadership studies. To continue this journey, and to help contributors frame and develop their work for submiss
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effe
Rapporten utgör ett underlag till Jämställdhetsmyndighetens fördjupadeuppföljning av det jämställdhetspolitiska delmålet att mäns våld mot kvinnor skaupphöra.
Brevmall 1 Konstnärliga fakulteten i Malmö Disputation och examen inom forskarutbildning Denna guide är framtagen som stöd under disputationsprocessen för doktorander antagna enligt särskild överenskommelse om forskarutbildning mellan Konstnärliga fakulteten, Lunds universitet och - doktorander som antagits inom Konstnärliga forskarskolans (KF) ram, - doktorander i musikpedagogik vid Kungl. Musikh
Letter of invitation in order to obtain visa to Sweden 2 Letter of invitation in order to obtain visa to Sweden The Department of XXXX at Lund University in Sweden hereby invites den sökandes fullständiga namn (enligt pass) den sökandes födelsedatum den sökandes passnummer XXXX (namn) is going to be visiting Sweden (for less than 90 days) in order to varför . Beskriv besöket, vad vederbörande ska
Syftet med denna uppsats är att beskriva och analysera sponsringsverksamhetens utveckling och potential för att se vilken betydelse verksamhetens rykte som en bidragsverksamhet har för utvecklingen av sponsring till en affärsverksamhet. Vi har i samband med detta även tittat på vilka nya krav denna utveckling ställer på elitidrottsföreningar. De teorier vi har använt oss av för att analysera klubb
Detection of P. falciparum-specific subpopulations of B-cells is important for studies of immunity in malaria. This protocol relies on the photostability and protein loading capacity of carboxylated quantum dots to detect a broad range of different P. falciparum-specific B-cells. Infected red blood cell ghosts, obtained by permeabilization of infected cells with Streptolysin O, are coupled with ca
The idea that some people completely lack inner speech is of both scientific and popular interest. In a recent study, Nedergaard and Lupyan compared self-reporting high and low inner-speech-prevalence groups and found that participants in the low-prevalence group performed worse on a verbal working memory test and responded more slowly and less accurately during rhyme judgments. These results repr
Despite systematic screening and improved treatment strategies, the prognosis remains worse in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) compared to patients with idiopathic/hereditary pulmonary arterial hypertension (IPAH). We aimed to investigate differences in clinical characteristics, outcome and performance of the European Society of Cardiolo
