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Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. However in practice, these have encountered unexpected mechanisms of resistance in many solid tumors, highlighting the need for furthe
Mörk materia har funnits sedan tidernas begynnelse, från den Stora Smällen. Under Universums första hundratals miljoner år var tyngdkraften från den mörka materian så kraftfull att den drog till sig den vanliga materian, som muskler till revben, och formade gigantiska strukturer. De första galaxerna växte där dessa strängar möttes.Galaxer kolliderade med andra galaxer, och slogs samman för att
This essay should be regarded as an artifact study and as a foundation for continued research. As very little has been written about younger blackware, the focal point of this study is on key problems such as dating, function and production. The material of the study is from the excavation of Kv. Apotekaren 4, carried out 1979-1980. The stratigraphy of the site was well dated with dendrochronology
Brevmall 1 Konstnärliga fakulteten i Malmö Disputation och examen inom forskarutbildning Denna guide är framtagen som stöd under disputationsprocessen för doktorander antagna enligt särskild överenskommelse om forskarutbildning mellan Konstnärliga fakulteten, Lunds universitet och - doktorander som antagits inom Konstnärliga forskarskolans (KF) ram, - doktorander i musikpedagogik vid Kungl. Musikh
The aim of this study was to investigate how patients perceive information and their health-related quality of life 1 month after discharge for colorectal cancer surgery. The aim was also to compare these results with the first 2 weeks at home and to identify factors related to the perception of information. One hundred patients from three surgical clinics in the south of Sweden were included in t
We have used proteomic fingerprinting to investigate diagnosis of Alzheimer's disease (AD). Samples of lumbar cerebrospinal fluid (CSF) from clinically-diagnosed AD cases (n = 33), age-matched controls (n = 20), and mild cognitive impairment (MCI) patients (n = 10) were used to obtain proteomic profiles, followed by bioinformatic analysis that generated a set of potential biomarkers in CSF samples
Glycosaminoglycans comprise linear polysaccharide containing repeated disaccharide units. When one of the disaccharide units of chondroitin sulfate, glucuronic acid, gets epimerized by dermatan epimerase 1 to iduronic acid, dermatan sulfate is formed. Dermatan sulfate is essential in tumorigenesis, due to increased flexibility in the chain and enables interaction with certain proteins such as cyto
We report on the versatile design and operation of a two-sided spectrometer for the imaging of charged-particle momenta in two dimensions (2D) and three dimensions (3D). The benefits of 3D detection are to discern particles of different mass and to study correlations between fragments from multi-ionization processes, while 2D detectors are more efficient for single-ionization applications. Combini
Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes.
Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Me
The limiting factor for lung transplantation is the lack of donor organs. The usage of lungs from donation after cardiac death (DCD) would dramatically increase donor availability. In the present paper we wanted to investigate lungs exposed to 1 h of warm ischemia without heparin followed by flush-perfusion and cold storage compared to lungs harvested from heart beating donors (HBD) using standard
Rapport över utredning i Sydvästra Lund. Utredningen berörde perioderna neolitikum till tidigmoderntid och utgör en ledtråd till att förstå uppkomsten och placering av Lund.
Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-matrix interactions. In this study, we have determined the effects of the loss of beta1 integrins in keratinocytes in vitro and during cutaneous wound repair. Flow cytometry of cultured beta1-deficient keratinocytes confirmed the absence of beta1 integrins and showed downregulation of alpha6beta4 but not
The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of th
To investigate subjective and objective changes in function in subjects with Parkinson's disease (PD) home visits with interviews were performed with a 1-year interval. Depressive symptoms were rated with the Geriatric Depression Scale, subjective health with the generic SF-36 scale and the disease-specific PDQ-8 scale; objective changes were assessed according to the Hoehn and Yahr scale; insomni
