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BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies

The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit

The PreAmplifier ShAper for the ALICE TPC detector

In this paper the PreAmplifier ShAper (PASA) for the Time Projection Chamber (TPC) of the ALICE experiment at LHC is presented. The ALICE TPC PASA is an ASIC that integrates 16 identical channels, each consisting of Charge Sensitive Amplifiers (CSA) followed by a Pole-Zero network, self-adaptive bias network, two second-order bridged-T filters, two non-inverting level shifters and a start-up circu

Analysis of the molecular interplay between Streptococcus pyogenes and its human host

The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl

Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein.

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib

Derivation of efficiency factors for uneven irradiation on a fin absorber

In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency

Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy

Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i

Eosinophil granulocyte interaction with serum-opsonized particles: binding and degranulation are enhanced by tumor necrosis factor alpha

Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel

New treatments in hemophilia: insights for the clinician.

Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in

Two major classes in the M protein family in group A streptococci

The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh

Investigation on the effects of fly ash particles on the thermal radiation in biomass fired boilers

Ash is produced in combustion of biomass. Sonic part of this matter is called fly ash and is carried by the flow and causes not only air pollution and erosion, but also call affect the thermal radiation. The effects of fly ash particles oil the thermal radiation are considered ill this investigation. By analyzing sampled data in all electrostatic filter, a realistic particle size distribution is f

Sharing session: "The Upheaval"

26 February 2026 15:00 to 16:30 | Performance Skånes Dansteater has together with choreographer Philippe Blanchard initiated an exploratory project with the title "The Upheaval". The project involves a deeper conversation about ecologically sustainable practices within the performing arts. In February the team moves their ongoing studio practice temporarily to IAC and opens their artistic research

https://www.staff.lu.se/calendar/sharing-session-upheaval-skanes-dansteater - 2026-05-02

2010: Finished PhD projects

Human Ecology DivisionCarl Nordlund     "Social Ecography; International trade, network analysis, and an Emmanuelian conceptualization of ecological unequal exchange"Presentation: Defence date: 11th October 2010. This thesis demonstrates how network analysis, ecological economics and the world-system perspective can be combined into an ecographic framework that can yield new insights into the unde

https://www.keg.lu.se/en/research/research-projects/finished-phd-projects/2010-finished-phd-projects - 2026-05-01

Beyond Blueprints: Adoption of AI in Architecture

This thesis investigates the adoption of artificial intelligence (AI) solutions among architects in Sweden. Architects are currently experiencing headwinds and decreased demands for their services as increasing interest rates and a weak economy have contributed to a decline in construction activity. Simultaneously, advancements in AI have introduced a range of innovative technologies to the field

Shopping Malls and Consumption

Shopping malls are a global phenomenon, and as such they reach a degree of local iconicity simply by being malls. One of the main roles shopping malls play in our everyday lives is nurturing social interactions. Shopping malls have been portrayed by many scholars as places where people go to practice consumer religion (Fiske, 1989; Ritzer, 1999; Zepp, 1997), prime temples which glorify consumption

From Tweets to the Streets. New Media and Political Engagement - A Case Study of Amnesty International and the Egyptian Uprisings

Despite the so-called ‘great retreat’, in which people arguably are distancing themselves from the political sphere and civic engagement, the last two years has seen an upsurge in political activities. Outside the realms of institutionalised politics, i.e. political parties, lies a whole terrain of alternative political activities, including social movements and media institutions. Following the E

Staying Relevant in the Roman Republic Old Age, Retirement and Magistrates in the Early to Middle Republic

This essay explores the magistratal lists (fasti etcetera) covering the period of 509 to 219 BC by looking at an accumulation of political capital and the length of magistratal careers. This essay attempts to give evidence to several theories for the early and middle Republic, primarily the fact that retirement of consulars occurs around the age of 60-65 and that one started one's consular car