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Oral Methadone versus Morphine IR for Patients with Cervical Cancer and Neuropathic Pain : A Prospective Randomised Controlled Trial

Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often

A Proactive Cloud Application Auto-Scaler using Reinforcement Learning

This work explores the use of reinforcement learning to design a proactive cloud resource auto-scaler that is able to predict usage across a distributed microservice application. The focus is on serving time-sensitive workloads, e.g., industrial automation, connected XR/VR (eXtended Reality/Virtual Reality), etc., where each job has a deadline and there is some cost associated with missing a deadl

Human astrocytes transfer aggregated alpha-synuclein via tunneling nanotubes

Many lines of evidence suggest that the Parkinson’s disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from embryonic stem cells actively transfer aggregated α-SYN to nearby astrocytes via direct contact and tunneling nanotubes (TNT

End-of-life treatments in pediatric patients at a government tertiary cancer center in India

Aim: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. Methods: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data

CRISPR editing of the PPARGC1A Gly482ser (rs8192678) polymorphism in human white adipose cells shows differential effects on mitochondrial function and adipogenesis.

Background and aims: PPARGC1A encodes PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1-α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipoc

Prevalence and severity of differing dimensions of breathlessness among elderly males in the population

Breathlessness is common in the general population. Existing data were obtained primarily with the uni-dimensional modified Medical Research Council breathlessness scale (mMRC) that does not assess intensities of unpleasantness nor physical, emotional and affective dimensions. The aim of this research was to determine the prevalence and intensity of these dimensions of breathlessness in elderly ma

Integrated Daylight and Energy Evaluation of Passive Solar Shadings in a Nordic Climate

Modern well-insulated and highly glazed buildings experience increased overheating, even in cold climates. The study focused on external and internal passive solar shadings on a south-oriented façade, having predetermined that external and internal shadings’ main function is solar heat gain and glare protection, respectively. A daytime-occupied office space with several external shading geometry v

MULTI-CRITERIA ASSESSMENT AND PROCESS SELECTION MODEL FOR ADDITIVE MANUFACTURING IN THE CONCEPTUAL PHASE OF DESIGN

Additive manufacturing (AM), which was first applied for rapid prototyping, is now becoming a real option for small-batch production of final products. Further expansion of AM is closely correlated to production costs. AM can only become competitive to traditional manufacturing methods if a product is designed for AM already from the beginning as it is an expensive technology that should only be a

Effects of forest management on greenhouse gas fluxes in a boreal forest

Skogar täcker ca 31% av jordens landyta och lagrar stora mängder kol i biomassa och i marken. I klimatavtalet från Paris 2015 lyfts skogars roll som sänkor och reservoarer av kol fram och undertecknande länder uppmanas att implementera strategier för hållbart skogsbruk som ytterligare förstärker skogars roll som sänkor av växthusgaser. Ett aktivt skogsbruk påverkar klimat och miljö på många olika

Google AdWords och varumärkesanvändning på internet - En studie över den rättsliga hanteringen av sökordsannonsering i Sverige, Danmark, Norge och Storbritannien

För var dag som går blir vårt samhälle allt mer beroende av teknik och snabb och lättillgänglig information. De flesta av oss söker dagligen efter någon sorts information på internet. Vi gör sökningar på allt som är av intresse för oss för stunden och allt fler inköp görs numera på nätet. Med denna nya, teknikberoende livsstil har det blivit allt viktigare för företag att marknadsföra sina varor oFor each day that passes our society becomes more and more dependent on technology and a fast and easy access to information. Most of us are using internet on a daily basis in search of information. We search for information regarding most things in our lives, from health, lifestyle and food to information regarding travel and work-related issues. With this new, technology-dependent lifestyle it h

Marknadsföringsetik - inte helt utan problematik

Examensarbetets titel: Marknadsföringsetik - inte helt utan problematik - En kvalitativ studie om hur byråer i marknadsföringsbranschen hanterar etiskt beslutsfattande i traditionella och digitala medier. Seminariedatum: 2020-01-16 Ämne/kurs: FEKH29, Examensarbete i marknadsföring på kandidatnivå, 15 högskolepoäng Författare: Rebecka Bäcklin, Frida Lindgren, Elias Sovre Handledare: Burak Tunca NTitle: Marketing ethics - not entirely without problematics - A qualitative study of how agencies in the marketing industry handle ethical decision making in traditional and digital media. Seminar date: 2020-01-16 Course: FEKH29, Business Administration: Bachelor Degree Project in Marketing Undergraduate Level, 15 University Credit Points Authors: Rebecka Bäcklin, Frida Lindgren, Elias Sovré A

Learning about the learner : An analysis of policies for Swedish public libraries with focus on learning

This thesis examines how learning is depicted in policy documents for public libraries on municipal and national level in Sweden. The documents analyzed are library plans from five Swedish cities, as well as the proposal for a national strategy presented in 2019 by the National Library of Sweden. The method used is Carol Bacchi’s What’s the problem represented to be-approach. Pierre Bourdieu’s the

Automatic magnetic resonance brain volume measurements to assess the effect of minimised blood sample extraction on brain development in extremely preterm infants

ar. Enorma framsteg har gjorts de senaste decennierna i neonatalvården (vård för nyfödda barn) och omkring 80% av EPT-barn i Sverige överlever. Dessa framsteg innefattar bl.a. administrering av kortison för att påskynda lungmognaden, modern teknisk utrustning, bättre kunskaper om neonatala sjukdomar m.m. Globalt är överlevnaden av EPT-barn lägre i länder med sämre ekonomiska förutsättningar och däAim: To evaluate a pipeline for automatic MRI brain segmentation and volumetric tissue structure quantification in a cohort of extremely preterm infants. Methods: 13 extremely preterm neonates underwent MRI-scanning at a term equivalent age. Seven of these subjects had suitable MRI sequences and were analyzed in the pipeline. Segmentation of MRI brain images into brain tissue types and parcellati

Dimensions of trust in scholarly communication : problematizing peer review in the aftermath of John Bohannon’s ‘Sting’ in Science

This study investigates online material published in reaction to a Science magazine report showing the absence of peer-review and editorial processes in a set of fee-charging open access journals in Biology. Quantitative and qualitative textual analyses are combined to map conceptual relations in these reactions; and to explore how understandings of scholarly communication and publishing relate to

Mechanical Tensioning of High-Strength Aluminum Alloy Friction Stir Welds

The extent to which in-situ global mechanical tensioning (GMT) can be used to modify the residual stress state in friction stir (FS) welds is investigated in this article. Residual stress distributions have been determined by synchrotron X-ray and neutron diffraction for four sets of FS welds in high-strength AA7449-W51 and lithium containing AA2199-T8 aerospace aluminum alloys subjected to a syst

Frihet, bildning och kodifikation - En idéhistorisk studie i hur Sverige blev utan jury i allmän domstol

Denna uppsats undersöker införandet av jury i Sverige under 1800-talets första hälft. Jury infördes i tryckfrihetsmål år 1815 men aldrig i allmän domstol. Hur det sistnämnda gick till tenderar att infogas i en större forsk-ningsdiskussion om de så kallade kodifikationsstriderna mellan liberala aktörer och den tyska historiska skolans företrädare under 1800-talets första årtionden. Detta betyder inThis thesis examines the implementation of juries in Sweden during the first half of the eighteenth century. Juries were implemented in cases regarding breaches of the press law in 1815, but never in general courts. How the latter came to be tends to be inserted into a larger discussion regarding the so-called codification battles between liberal actors and representatives of the German historical

Trade Liberalization and Tax Reforms in Cape Verde

When a country liberalizes trade through lowering taxes on imports, it stands before a number of challenges. Recovering lost trade tax revenue is one of them. Cape Verde is one of the countries that are currently negotiating an Economic Partnership Agreement with the EU and studies predict that the tariff reductions resulting from the agreement may have a severe impact on Cape Verde’s government r

Elizabeth Bennet vs Katniss Everdeen

Analys av hjältinnan utifrån ett feministiskt perspektiv. En jämförelse mellan Jane Austens hjältinna Elizabeth Bennet i Pride and Prejudice och Suzanne Collins hjältinna Katniss Everdeen i The Hunger Games.Analysis of the heroine from a feminist perspective. A comparison between Jane Austen's heroine Eliabeth Bennet in Pride and Prejudice and Suzanne Collins' heroine Katniss Everdeen in The Hunger Games.

Custodio hipolito

Modeling the effect of genetic polymorphisms Balancing the nutritional benefits of fish consumption against methylmercury toxicity, and evaluating the impact of genetic polymorphisms in glutathione S-transferases on susceptibility to methylmercury in a Swedish population A thesis presented in partial fulfillment of the requirements of the Lund University International Master's Programme in Environ

https://www.lumes.lu.se/sites/lumes.lu.se/files/custodio_hipolito.pdf - 2026-05-30