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T cell surface redox levels determine T cell reactivity and arthritis susceptibility.

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to develop severe arthritis. These data suggest that ROS are involved in regulating the immune response. We now show that the lower capacity to produce ROS is associated with an increased number of reduced

Apical sorting by galectin-3-dependent glycoprotein clustering

Epithelial cells are characterized by their polarized organization based on an apical membrane that is separated from the basolateral membrane domain by tight junctions. Maintenance of this morphology is guaranteed by highly specific sorting machinery that separates lipids and proteins into different carrier populations for the apical or basolateral cell surface. Lipid-raft-independent apical carr

Strategies Applied by Women in Coping With ad-hoc Demands for Unauthorized User Fees During Pregnancy and Childbirth. A Focus Group Study From Angola.

Our aim in this study was to explore women's responses to reported ad-hoc demands for unauthorized user fees during pregnancy and childbirth in Luanda, Angola. Ten focus group discussions were conducted and data were analysed using grounded theory. Women were found to apply six strategies as they "endeavored to cope with demands for unauthorized user fees" (core category): (i) blowing the whistle,

Direkt profil: A system for evaluating texts of second language learners of French based on developmental sequences

Direkt Profil is an automatic analyzer oftexts written in French as a second lan-guage. Its objective is to produce an eval-uation of the developmental stage of stu-dents under the form of a grammaticallearner profile. Direkt Profil carries outa sentence analysis based on developmen-tal sequences, i.e. local morphosyntacticphenomena linked to a development in theacquisition of French.The paper pre

Modelling the gold market, explaining the past and assessing the physical and economical sustainability of future scenarios

By using an integrated dynamic model we are able to reconstruct the supply and gold price of the past (1920-2010) and this is used to predict the future supply of gold to the market and to make a forecast of the goldprice 2010-2100. The model was validated against field data for the period 1920-2010 and it performs well. The model GOLD is implemented in the STELLA® software and the model described

Techno-Economic Aspects of a Wood-to-Ethanol Process: Energy Demand and Possibilities for Integration

Full-scale ethanol production from spruce has been evaluated, mainly from an energy perspective, using an Aspen Plus-model including all major process steps. The model input was based on data recently obtained on lab scale or in a process development unit. A number of different process configurations are presented in order to demonstrate how heat integration within the ethanol process significantl

The interrogative model of inquiry and inquiry learning

Hakkarainen and Sintonen (2002) praise the descriptive adequacy of Hintikka's Interrogative Model of Inquiry (imi) to describe children's practices in an inquiry-based learning context. They further propose to use the imi as a starting point for developing new pedagogical methods and designing new didactic tools. We assess this proposal in the light of the formal results that in the imi characteri

Mucosal receptors involved in pathogen recognition and host defence

Urinary tract infection is the most common infection in man. P fimbriae are virulence factors of uro-pathogenic Escherichia coli. They are expressed by 70-90 % of acute pyelonephritis isolates and up to 100% of the most virulent isolates that cause bacteremia. This thesis concerns the interaction between P fimbriae and the urinary tract mucosa, and the host receptors involved in fimbrial recognit

Biosynthesis, Processing, and Sorting of Human Neutrophil Granule Proteins. Focus on Cathepsin G, Proteinase 3, and Azurocidin

Popular Abstract in Swedish Bildning, bearbetning och upplagring av cathepsin G, proteinas 3 och azurocidin - närbesläktade bakteriedödande proteiner i vita blodkroppar Människans kropp utsätts dagligen för fientliga attacker av olika sorters mikroorganismer, tillhörande bakterie-, virus- eller svampsläktet. Så länge vi är friska och vårt immunförsvar fungerar, kan vi som tur är framgångsrikt föThe neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding