Sökresultat

Reactive oxygen species (ROS) are important in the immune defense against invading pathogens, but they are also key molecules in the regulation of inflammatory reactions. Low levels of ROS production due to a polymorphism in the neutrophil cytosolic factor 1 (Ncf1) gene are associated with autoimmunity and arthritis severity in mouse models induced with adjuvant. We established an adjuvant-free ar

Ad hoc networks, being able to organize themselves without user intervention, can easily provide their users with mobility, multimedia support and group communication. However, they have to combine quality of service (QoS) and multicast routing strategies. This article defines the resource management and admission control components of the ad hoc QoS multicast (AQM) routing protocol, which achieve

Cellular metabolism of glucose is required for stimulation of insulin secretion from pancreatic beta cells, but the precise metabolic coupling factors involved in this process are not known. In an effort to better understand mechanisms of fuel-mediated insulin secretion, we have adapted 13C NMR and isotopomer methods to measure influx of metabolic fuels into the tricarboxylic acid (TCA) cycle in i

Haemophilus influenzae is a Gram-negative human pathogen that resides in the upper respiratory tract. Encapsulated H. influenzae type b (Hib) and type f (Hif) are the most common serotypes associated with invasive disease. H. influenzae displays various strategies to circumvent the host innate immune response, including the bactericidal effect of the complement system. In this study, we identified

Material interfaces occur at various length scales and may exhibit significantly different properties than the surrounding bulk. Motivated by their importance for electrical engineering applications such as wire bonds and electrically conductive adhesives, the focus of the present work is on material interfaces in electrical conductors. In order to approximate the physical interphase (of finite th

Seismic Structural Health Monitoring (S2HM) provides information about the integrity of civil structures and infrastructure in the aftermath of an earthquake. However, quantifying the benefits of S2HM information is crucial to justify the investment in S2HM systems. The benefit of S2HM can be computed through the Value of Information (VoI) from Bayesian decision theory, which compares the expected

We introduce a new method to calculate dark matter halo density profiles from simulations. Each particle is ‘smeared’ over its orbit to obtain a dynamical profile that is averaged over a dynamical time, in contrast to the traditional approach of binning particles based on their instantaneous positions. The dynamical and binned profiles are in good agreement, with the dynamical approach showing a s

In this paper we argue that Long Wave Theory provides a useful conceptual tool for understanding the transition from the industrial to the, post-industrial economy. While economic theories struggle to fully explain the structural changes involved in the shift towards the information economy, long wave theory offers a promising avenue for understanding the complex relationship between technology an

Vid den nordöstra kusten av den karibiska ön Grenada ligger en övergiven flygplats. Denna extraordinära miljö ligger i en dal mellan tropiska berg täckta av frodig regnskog. Landningsbanan är en 1,5 kilometer lång historisk startbana som möter Atlantens livfulla vatten. Grenada har redan drabbats av orkaner och andra tropiska stormar. Utvecklingen av klimatförändringar skapar oftare och mer intenOn the north east coast of the Caribbean island Grenada, there´s an abandoned airport. This extraordinary environment is located in a valley between tropical mountains covered by lush rain forest. The landing stripe is a 1,5-kilometer-long runway of history, facing the rough Atlantic Ocean. Grenada has already suffered badly from hurricanes and tropical storms. While climate changes are evolving

The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In pa

Cardioneuroablation has emerged as a potential alternative to cardiac pacing in selected cases with vasovagal reflex syncope, extrinsic vagally induced sinus bradycardia-arrest or atrioventricular block. The technique was first introduced decades ago, and its use has risen over the past decade. However, as with any intervention, proper patient selection and technique are a prerequisite for a safe

Modern working life is characterized by change and competiveness. It is also characterized by a drift away from low-skilled work to more complex jobs and increased social interaction. This means that the human resources employees and their skills, competencies, engagement and motivation are the greatest asset of many organizations. This has implications for how an organization can be healthy, i.e.

Departing from the hypothesis that R&D within ICT plays an essential role in the transformation of the construction sector from a traditional to an industrialised process, a joint Swedish and French project has been carried out (to be completed in April 2007) to assess the short and medium term possibilities to improve efficiency and quality in multi-storey house-building. This paper describes