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A Hidden Markov Model (HMM) is used to improve the robustness to noise when tracking the atrial fibrillation (AF) frequency in the ECG. Each frequency interval corresponds to a state in the HMM. Following QRST cancellation, a sequence of observed states is obtained from the residual ECG, using the short time Fourier transform. Based on the observed state sequence, the Viterbi algorithm, which uses
BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the
The mechanisms by which mycobacteria subvert the inflammatory defence to establish chronic infection remain an unresolved question in the pathogenesis of tuberculosis. Using primary epithelial cells, we have analysed mycobacteria induced epithelial signalling pathways from activation of TLRs to cytokine secretion. Mycobacterium bovis bacilli Calmette-Guerin induced phosphorylation of glycogen synt
This study describes how the serum protein histidine-rich glycoprotein (HRG) affects the complement system. We show that HRG binds strongly to several complement proteins: C1q, factor H and C4b-binding protein and that it is found complexed with these proteins in human sera and synovial fluids of rheumatoid arthritis patients. HRG also binds C8 and to a lesser extent mannose-binding lectin, C4 and
Background: Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD) exacerbations exhibit TH(2)-like inflammation. We hypothesized that RV-infected bronchial epithelial cells (BEC) overproduce TH(2)-switching hub cytokine, thymic stromal lymphopoietin (TSLP) in COPD. Methods: Primary BEC from healthy (HBEC) and from COPD donors (COPD-BEC) were grown in 12-well plates, infected with RV
OBJECTIVES: We evaluated the prevalence and mechanism of poor responsiveness to clopidogrel and prasugrel in coronary artery disease patients with and without diabetes. BACKGROUND: Low platelet inhibition by clopidogrel is associated with ischemic clinical events. A higher 600-mg loading dose (LD) has been advocated to increase responsiveness to clopidogrel. METHODS: In this study, 110 aspirin-tre
This paper studies the interdependence between R&D resources and standardization performance in development-related standardization settings under strong network effects. Standardization performance is viewed as the firm’s involvement in the change process of standards as a result of the business processes of standardization. We utilize a sample from the 3GPP change request database to study f
Popular Abstract in Swedish Vårt immunförsvar arbetar konstant med att skydda kroppen från olika föremål, t. ex. bakterier, virus, gifter och cancertumörer, som kan orsaka skada eller sjukdom. För att kunna försvara kroppen mot sådana föremål så har immunförsvaret tillgång till flera, oerhört effektiva, vapen. Det viktigt att immunförsvaret känner igen, och endast angriper, skadliga föremål, så atCD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. The central role of CD40 in the immune system makes it an ideal target for antibody based immunotherapy. This led us to charact
We present new in-situ measurements of particle rotations and energy dissipation during compression of 3D packings of stiff, frictional particles. Two confined, uniaxial compression tests with different degrees of lateral confinement are discussed. X-ray computed tomography and 3D X-ray diffraction were combined to provide inter-particle forces, slip and roll distances, twist angles, and energy di
Design of discontinuity regions in reinforced concrete is today often performed with Strut and Tie Method (STM) or linear finite element analyses (LFEA). However, it is questionable to what extent these design methods are appropriate with regard to resistance, ductility, serviceability and economic reinforcement arrangement. In design with STM a simple equilibrium model based on plasticity theory
In the design of concrete bridges an important aspect is limiting crack widths, since large cracks can lead to e.g. corrosion and affect the bridge functionality. Restraint forces caused by thermal loads and shrinkage will likely constitute a large part of the total forces acting on the bridge in crack width design. In this paper, restraint stresses in portal frame bridges are calculated according
