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Background: Noise is typically conceived of as being detrimental to cognitive performance. However, given the mechanism of stochastic resonance, a certain amount of noise can benefit performance. We investigate cognitive performance in noisy environments in relation to a neurocomputational model of attention deficit hyperactivity disorder (ADHD) and dopamine. The Moderate Brain Arousal model (MBA;
Impinging flame jets are widely used in applications where high heat-transfer rates are needed, for instance in the glass industry. During the heating process of glass products, internal thermal stresses develop in the material due to temperature gradients. In order to avoid excessive thermal gradients as well as overheating of the hot spots, it is important to know and control the temperature dist
A fracture mechanics model for analysis of crack initiation and propagation in wood is defined and applied. The model has the advantage of being simple, yet it enables reasonably general and accurate analysis commonly associated with more complex models. The present applied calculations are made by means of the finite element method and relate to progressive cleavage fracture along grain. The calc
This document is a description of the computer code OSFIC. The development of the code was sponsored by the Swedish Nuclear Power Inspectorate as an effort to develop useful tools for fire analyses in nuclear power plants. The name OSFIC stands for "OilSpill Fires In Compartments". The purpose of this paper is to describe the code and to facilitate the use of the computer program. A more detailed
The moral philosophy of Levinas offers a stark prospectus of impossibility for corporate ethics. It differs from most traditional ethical theories in that, for Levinas, the ethical develops in a personal meeting of one with the Other, rather than residing in some internal deliberation of the moral subject. Levinasian ethics emphasises an infinite personal responsibility arising for each of us in t
Several new oral antidiabetic agents, known as 'gliptins' or 'enzyme dipeptidyl peptidase-IV (DPP-4) inhibitors', have been developed for the treatment of type 2 diabetes and a key clinical use of the gliptins is in combination with metformin. There are important differences in the kinetics of the interaction of different gliptins with the catalytic site of DPP-4, which may lead to varying pharmac
Morbidity and mortality resulting from acute and subsequently chronic graft-versus-host disease (GVHD) pose a serious challenge to wider applicability of allogeneic stem cell transplantation (SCT). Mycophenolate mofetil (MMF) is a widely used drug in combination with a calcineurin inhibitor and often cyclosporine (CsA), in preventing GVHD. The use of MMF for acute GVHD (aGVHD) prophylaxis appears
The introduction of Rituximab has greatly improved therapeutic options for patients with B-cell non-Hodgkin lymphoma (B-NHL). However, a substantial fraction of patients with aggressive B-NHL fails first-line therapy, and most patients with relapsing indolent B-NHL eventually acquire Rituximab resistance. Molecular understanding of the underlying mechanisms facilitates the development of pharmacol
Background: Long-term care for stroke survivors is fragmented and lacks an evidence-based, easy-to-use tool to identify persistent long-term problems among stroke survivors and streamline referral for treatment. We sought to develop a poststroke checklist (PSC) to help health care professionals identify poststroke problems amenable to treatment and subsequent referral. Methods: An instrument devel
In the search for improved glucose oxidising enzymes for biofuel cells, a number of Agaricus meleagris (Am) pyranose dehydrogenase mutants (mPDHs) exhibiting different degrees of glycosylation were produced using site-directed mutagenesis and electrochemically characterised. The response of electrodes modified with different mPDHs is compared in a mediated electron transfer mode, where the electro
This article takes Italy’s widely-debated 2009 push-backs to Libya campaign as a point of reference to address whether bilateral agreements for technical and police cooperation provide the legal foundation for the forced return of intercepted refugees to countries of embarkation. Through a detailed analysis of both the facts and the texts of the published and unpublished bilateral accords, it conc
Societal safety and sustainability are key challenges in our complex and dynamic world, causing growth in interest of applying the concept of resilience in broader societal contexts. This paper presents a concept of Community Resilience that builds on established theory of Resilience Engineering and operationalises the concept by presenting its purpose, required functions and a way to identify and
Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f ), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred wolf population. Yet, our data show that for each level of f, it was the most heterozygous wolves t
Popular Abstract in Swedish Venös trombossjukdom (blodpropp i ben och lunga) förekommer i en frekvens av ca 160 per 100.000 invånare och år i Malmö. Venös trombossjukdom är en av våra vanligaste sjukdomar. Bakgrunden till venös trombossjukdom är mångfacetterad och både ärftliga och förvärvade riskfaktorer bidrar till sjukdomen. Kända riskfaktorer är övervikt, immobilisering (ex gipsbehandling, slaActivated protein C resistance (APC resistance) is the most common hereditary condition associated with venous thrombosis. The syndrome known as APC resistance is perfectly linked to a mutation in the gene coding coagulation FV (FV:Q506) mutation changing Arg 506 to Gln in the APC cleavage site. APC-resistance is associated with a hypercoagulable state and life-long increased risk of thrombosis. A
