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Detection of cleavage sites for HIV-1 protease in native proteins

Interaction between the labile binding site of human C4 and methylamine

Human complement component C4 was irreversibly inactivated by low concentrations of methylamine at slightly alkaline pH. The inactivated C4 molecules lost the ability to bind to EAC1 cells but retained th capacity to participate in the formation of classical pathway C3 convertase in the fluid phase. 14C-methylamine was incorporated into the alpha-chain at a ratio of 1 mol methylamine per mol C4.

Shortcoming in current practice of decision-making in contaminated site remediation

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

The galectins are a family of galactose-binding proteins playing key roles in inflammatory processes and cancer. However, they are structurally very closely related, and discovery of highly selective inhibitors is challenging. In this work, we report the design of novel inhibitors binding to a subsite unique to galectin-3, which confers both high selectivity and affinity towards galectin-3. Olefin

Mapping of the H-kininogen binding site exposed by the prekallikrein heavy chain

Ultrasonography in psoriatic arthritis: Which sites should we scan?

Decoration of bone and antler artefacts as an indication of Mesolithic networks : Finds from a central Swedish late Mesolithic site

Generation of new enzyme inhibitors using imprinted binding sites : The anti-idiotypic approach, a step toward the next generation of molecular imprinting

Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C

BACKGROUND: Antibacterial peptidyl derivative - Cystapep 1, was previously found to be active both against antibiotic-resistant staphylococci and streptococci as well as antibiotic-susceptible strains of these species. Therefore, it is a promising lead compound to search for new antimicrobial peptidomimetics.OBJECTIVES: We focused on identifying structural elements that are responsible for the bio

Site of action of antinociceptive acupuncture-like nerve stimulation in the spinal rat as visualized by the 14C2deoxyglucose method

Site of action of antinociceptive acupuncture like nerve stimulation in the spinal rat as visualized by the 14C-2-deoxyglucose method

Aim: It has been claimed that supraspinal structures are necessary forthe depression of nocifensive behaviour elicited by acupuncture or acupuncturelike (AL) stimulation. However, nocifensive reflexes in the spinal catwere inhibited for long periods by a mechanism releasing opieids on AL conditioning stimulation of groups II-III muscle afferents (Sj~lund and Eriksson, Neurosci.Lett. S3:264:1979).

Some anticonvulsants interact with the GABA receptor-ionophore complex at barbiturate/picrotoxin receptor sites

Convulsant and anticonvulsant drug binding sites related to GABA-regulated chloride ion channels.

Roman glass found on native sites in Scotland & north Northumberland – some preliminary thoughts

Web-sites, establishment and private international law

Characterization of Organic Aerosol Components at a European Aerosol Super-Site in Southern Sweden

South Scandinavian Wetland Sites and Finds from the Mesolithic and the Neolithic

An International Comparative Study Considering Site Production for Sustainable Construction

Leaning on our past: The sofa cushion as a site telling a story of rural craft in today’s society

Simulated canopy vegetation effects on snow conditions for a forest site using the Multi-Energy Balance option in SURFEX