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The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune regulation remains poorly understood. We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis. Our results show no mandatory role for CD103 expression on T cells for either the development or CD4(+)CD25(+) regulatory T (T reg) cell-mediated contro
Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demo
In FDCP2 myeloid cells, IL-4 activated cyclic nucleotide phosphodiesterases PDE3 and PDE4, whereas IL-3, granulocyte-macrophage CSF (GM-CSF), and phorbol ester (PMA) selectively activated PDE4. IL-4 (not IL-3 or GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association with phosphatidylinositol 3-kinase (PI3-K). TNF-alpha, AG-490 (Janus kinase inhibitor),
OBJECTIVES This study describes changes in high-frequency QRS components (HF-QRS) during percutaneous transluminal coronary angioplasty (PTCA) and compares the ability of these changes in HF-QRS and ST-segment deviation in the standard 12-lead electrocardiogram (ECG) to detect acute coronary artery occlusion. BACKGROUND Previous studies have shown decreased HF-QRS in the frequency range of 150–
Abstract The overarching aim of this paper is to investigate the importance of technological shifts and national macroeconomic preconditions for long term growth and structural transformation in various regions in a national regional system. Intrinsic to this, the issue and origin of divergence and convergence coming in repetitive waves in regional systems will be discussed as a possible contribut
There are a number of interpretations of the concept “integration” in Product Development (PD). Different sources tend to use different terminologies for describing the same phenomenon of integration, or use the same term for different purposes. This paper strives to capture the essence of the concept of “integration” within a product development project by looking for what is integrated and how i
This paper presents a solution to panoramic image stitching of two images with co- inciding optical centers, but unknown focal length and radial distortion. The algorithm operates with a minimal set of corresponding points (three) which means that it is well suited for use in any RANSAC style algorithm for simultaneous estimation of geometry and outlier rejection. Compared to a previous method for
Extremely large filled-aperture ground-based optical-IR telescopes, or ELTs, ranging from 20 to 100m in diameter, are now being proposed. The all-important choice of the aperture must clearly be driven by the potential science offered. We here highlight science goals from the Leiden Workshop in May 2001 suggesting that for certain critical observations the largest possible aperture - assumed to be
Vid den nordiska konferensen ”Teaching bioethics” illustrerade transplantationskirurgen Nils H. Persson och jag hur en dialogpedagogisk metod kan belysa en frågeställning på ett sätt som är svårt för en ensam lärare. Nils H. Persson diskuterade bland annat den stora skillnaden i frekvens av organdonationer mellan de nordiska länderna, mindre än 15 PMP (per million population), och Spanien, mer än
In this paper, tone mapping operations based on the nonlinear successive Mean Quantization Transform (SMQT) are proposed in order to convert high dynamic range images to low dynamic range images. A SMQTbased tone mapping applied on the luminance channel is derived as well as a SMQT-based method working directly on all RGB channels. Both methods are compared to other state-of-the-art methods and pr
We have in this study analyzed the function of the murine Joining chain (J chain) in vivo. J chain is a polypeptide found in sera and secretions in complex with pentameric IgM and dimeric IgA. J chain is expressed in terminally differentiated B lymphocytes and needed for the transport of dimeric IgA and pentameric IgM over mucosal surfaces via the poly Ig receptor. A mouse deficient for J chain wa
This article outlines an experimental and numerical study of the long-term interaction between silica fume and Portland cement in concrete subjected to air, water or sealed curing. For this purpose about 2000 kg of eight qualities of concrete were studied at 4 different ages each over a period of 90 months. Half of the concretes contained silica fume. Parallel studies of strength, hydration and in
The article explores influences from Old Testament and Gnostic sources upon Japanese video game culture and also discusses the relationship between the player and the played in said games - from a perspective rooted in an exegesis of such texts. It also concerns the pop-culture climate of the 1990s and early 2000s in this context.
Wave cycle distributions are notoriously difficult to calculate. Available analytic approximations, like those suggested by Longuet-Higgins (1983) and Cavanie, Arhan and Ezraty (1976) make use only of a few spectral moments, and are unreliable for moderate waves. To find distributions under general spectrum shape and parameters one has to use efficient numerical algorithms based on high-dimensiona
The World Wide Web is undoubtedly very successful. Despite that, limitations have been recognized. The basic limiting factor is that the Web handles document for humans to read but not data and information for computers to read. The remedy of this is to provide the Web with semantics: the Semantic Web. While I agree that there is a need for another organization in which it is easier to find the in
The present study aimed to investigate the relationship between growth rate, final mass, and larval development, as well as how this relationship influences reproductive trade-offs, in the context of a gregarious life-style and the need to keep an optimal group size. We use as a model two sympatric populations of the pine processionary moth Thaumetopoea pityocampa, which occur in different seasons
