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Real-world evaluation studies have shown that many patients with asthma remain symptomatic despite treatment with inhaled corticosteroids (ICSs). As conventional ICSs have poor access to the peripheral airways, the aim of the present paper was to study the relationship between peripheral airway inflammation and clinical control in allergic asthma. Consequently, bronchial and transbronchial biopsie
MYCN, a proto-oncogene normally expressed in the migrating neural crest, is in its amplified state a key factor in the genesis of human neuroblastoma (NB). However, the mechanisms underlying MYCN-mediated NB progression are poorly understood. Here, we present a MYCN-induced miRNA signature in human NB involving the activation and transrepression of several miRNA genes from paralogous clusters. Sev
A whole complement ELISA-based assay kit, primarily designed to screen for deficiencies in components of the complement system was developed during a European Union grant involving more than a dozen European scientists and a small-medium enterprise company (Wieslab, which later merged into Eurodiagnostica). The consortium was led by Prof. Mohamed R. Daha who had already guided a preceding European
The distinction between thermodynamic and kinetics in cellulose dissolution is seldom considered in the literature. Therefore, herein an attempt to discuss this topic and illustrate our hypotheses on the basis of simple experiments was made. It is well-known that cellulose can be dissolved in a aqueous sodium hydroxide (NaOH/H2O) solvent at low temperature but it is here shown that such an alkalin
Earlier work has shown that pre-B cells can be converted into macrophages by the transcription factor CCAAT/enhancer binding protein a at very high frequencies. Using this system, we performed a systematic analysis of whether during transdifferentiation the cells transiently reactivate progenitor-restricted genes or even retrodifferentiate. A transcriptome analysis of transdifferentiating cells sh
During recent years, mobile phone companies have experienced market-related difficulties that result in increasing competition globally. In an attempt to maintain or increase their market share, enterprises reorganize their resources and employ new technologies to sharpen their competitive edges. Moreover, with the globalization, more and more companies become multi-sited. Efficient and timely col
This chapter is an investigation of ways to define Africanness in relation to African theology and Christianity.
In this paper a methodological approach for the analysis of nonstationary heart rate variability (HRV) signals using time-varying frequency bands based on respiratory frequency is presented. Spectral analysis of HRV is accomplished by means of the Smoothed Pseudo Wigner Ville distribution. Different approaches to the definition of the low frequency (LF) and high frequency (HF) bands are considered
Joseph Beuys. Fat and felt. A critical essay. The extremely singular materials fat and felt for use in art, have an entirely dominating role in a long series of Joseph Beuys’ (1921-1986) most important work. They are found both in single works of art as well as in installations and happenings from the beginning of the 1960s and up to the end of the artist’s life. This essay deals with the artist’
High-throughput multiplexed protein quantification using mass spectrometry is steadily increasing in popularity, with the two major techniques being data-dependent acquisition (DDA) and targeted acquisition using selected reaction monitoring (SRM). However, both techniques involve extensive data processing, which can be performed by a multitude of different software solutions. Analysis of quantita
Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-3
There has been recent speculation that the cores of intermediate-mass stars stripped of their envelopes by tidal interaction with the supermassive black hole in the Galactic Centre could form a population observationally similar to the so-called Sgr A* cluster or 'S' stars, which have close eccentric orbits around the hole. We model the evolution of such stars, and show that the more luminous end
We study the nature of the [Ti II] and [Ni II] emission from the so-called strontium filament found in the ejecta of eta Carinae. To this purpose, we employ multilevel models of the Ti II and Ni II systems, which are used to investigate the physical condition of the filament and the excitation mechanisms of the observed lines. For the Ti II ion, for which no atomic data were previously available,
