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Several studies have shown associations between shorter telomere length in blood and weakened immune function, susceptibility to infections, and increased risk of morbidity and mortality. Recently, we have shown that malaria accelerates telomere attrition in blood cells and shortens lifespan in birds. However, the impact of infections on telomere attrition in different body tissues within an indiv
The importance of the subchondral bone plate of the acetabulum when preparing the pelvis for a cemented acetabular cup during total hip arthroplasty (THA) has been investigated using finite element analysis. The effect of retaining or removing the subchondral bone plate and the use of anchoring holes are compared. Loading was applied via both hip joint contact force and the activity of up to 22 mu
Osteoarthritis (OA) is a progressive degenerative joint disorder, and the prevalence increases with age. In Sweden, about one in 4 people over the age of 45 years has OA in at least one joint. As the population ages and the prevalence of obesity increases, OA is expected to increase even more. The knee joint is one of the most commonly affected joints. Total knee arthroplasty (TKA) is the most com
A method and a model are presented aiming at enabling collection, structuring and analyzes of data concerning interdependencies between critical infrastructures and societal functions. A key distinction of the approach is the separation of actors and flows, where dependencies between actors, ranging from small municipal authorities to international private companies, are mediated through flows. Fl
BACKGROUND: In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015.METHODS: We estim
The European project was founded on the advancement of liberal democracy where the rule of law and respect for human rights have a central place. In a period of ‘instability’ in the Union where organisational changes to national judiciaries have raised fears over rule of law backsliding among Member States threatening the functioning of the European Union’s legal order. It is necessary to facilita
In this master´s thesis I seek to explore the concept of restorative justice, an ideological approach to justice which aims to repair the harm caused by crime through means of communication, cooperation, participation and restoration. By involving all parties affected by crime, restorative justice seeks to address crime through empowering victims, increasing community cohesion and making offenders
Bakgrund: Till följd av att den globala konkurrensen tilltar, ökar komplexiteten, flexibiliteten och produktvariationen inom produktion. Detta leder till att förbättringsprojekt blir allt svårare att genomföra. Händelsestyrd simulering har i litteraturen blivit identifierat som ett verktyg med förmågan att lösa dessa utmaningar, men till följd av att komplexiteten i en produktion ökar, växer ocksåBackground: Following a growing global competition, complexity, flexibility and product variability of manufacturing systems are increasing. This has led to improvement projects becoming more difficult to carry out. Discrete event simulation (DES) has in literature been identified as having the capability to solve these challenges, but as complexity of a manufacturing system increases so does also
Introduction: Treatment after Anterior Cruciate Ligament (ACL) injury includes physical therapist supervised neuromuscular training, with or without surgical reconstruction, aiming to improve patient-reported outcomes and muscle function. Despite this treatment, sensorimotor deficiencies persist, possibly constituting a contributing factor for risk of re-injury, early-onset osteoarthritis, and a l
Sex-based differences influence incidence and outcome of infectious disease. Women have a significantly greater incidence of urinary tract infection (UTI) than men, yet, conversely, male UTI is more persistent, with greater associated morbidity. Mechanisms underlying these sex-based differences are unknown, in part due to a lack of experimental models. We optimized a model to transurethrally infec
Background: Listening effort seems to depend on input-related listening demands and several factors internal to the individual listener. Input-related demands may be listening in noise compared with listening in quiet, and internal factors may be cognitive functions. Purpose: The purpose was to apply measures of listening effort and perceived listening effort in participants with normal hearing, t
Antimicrobial peptides (AMPs) are a diverse family of peptides that defend the mucosal surfaces of the oral cavity and other locations. Many AMPs have multiple functions and properties that influence aspects of innate defense and colonization by microorganisms. The human oral cavity is home to the second-most diverse microbiome, and the health of the mouth is influenced by the presence of these ba
Background: The strongest risk factor for falls is a history of falls. Therefore, interventions targeting persons at risk of falling before they are aware of the risk themselves is highly demanded. The prevention of falls is a complex task and has no easy solutions; an interdisciplinary approach is necessary. Modern technology provides us with novel opportunities to detect and monitor falls and ne
Den svenska psykiatrins avinstitutionalisering innefattade visionen att stärka patienters autonomi. I klinisk vardag manifesteras detta bland annat genom en ökad förväntan på att patienter ska fatta aktiva beslut om den egna vården. Föreliggande enkätstudie syftade till att undersöka självskattad grad av autonomi bland patienter inom öppenvårdspsykiatrin i Skåne (n = 63). Vidare undersöktes sambanThe deinstitutionalization of Swedish psychiatry included a vision to strengthen patients’ autonomy. In clinical practice, this is manifested through increased expectations on patients to make active decisions about their own care. This study aimed to examine self-rated autonomy among psychiatric outpatients in Skåne (n = 63). Furthermore, the association between autonomy and functional impairment
An increasingly amount of parents choose to drive their children to the school. The tendency has increased to a point when schools parking areas is too congested which impairs road safety. When motorists no longer have any space to legally unload their kids, they park in unsuitable locations that significantly increase the risk of an accident. The increasing amount of car driving is not only creat
Background: In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested. Objectives: The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens. Study design: Self-collected vaginal, ur
Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa.
Objective: To assess mortality in patients with rheumatoid arthritis ( RA) treated with tumour necrosis factor (TNF) inhibitors, compared with a standard RA population. Methods: Patients were recruited from a regional register, which includes over 90% of patients with RA treated with TNF blockers in the area in 1999 or later, and a local community-based cohort of patients with RA, established in 1
In 1617, after seven years of war between Sweden and Russia and talks facilitated by English and Dutch diplomats, the peace treaty of Stolbovo was signed. This important but little-studied document was to form the basis for relationships between Sweden and Russia for the next one hundred years, before it was replaced by the Peace of Nystad in 1721, and it had a huge influence on the lives of the p
