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The invasive oomycete pathogen Aphanomyces astaci significantly threatens native European crayfish populations, prompting investigations towards the effects of protective immunostimulation on the immune response of the vulnerable noble crayfish (Astacus astacus). Here, we evaluate the effect of three oomycete-derived immunostimulant treatments: laminarin (β-1,3-glucan found within the Ap. astaci c
In this thesis, I attempted to achieve a better understanding of the nature of X-linked polymorphic loci using a female-limited X chromosome (FLX) experimental evolution in Drosophila melanogaster. I expected that expressing the evolved X chromosome will result in an increase in female fitness and a decrease in male fitness. I first investigated the effect of an experimentally evolved female-limit
The current study aimed to characterize changes in EEG-related measures after noxious stimuli in neonates, and to assess their potential utility as measures of pain and/or discomfort during neonatal intensive care.Seventy-two healthy term infants were investigated: Twenty-eight had a non skin-breaking pin-prick on the heel, randomized to receive either oral glucose (n=16) or water (n=12) before th
Melanism, the process of heavier melanin deposition, can interact with climate variation at both micro and macro scales, ultimately influencing color evolution in organisms. While the ecological processes regulating melanin production in relation to climate have been extensively studied, intraspecific variations of melanism are seldom considered. Such scientific gap hampers our understanding of ho
BACKGROUND: Macrophage foam cell formation is a prominent feature of human atherosclerotic plaques, usually considered to be correlated to uptake of and inflammatory response to oxidized low density lipoproteins (OxLDL). However, there are alternative pathways for formation of macrophage foam cells and the effect of such lipid loading on macrophage function remains to be fully characterized. In th
The interaction between cooling and vasoactive substances, e.g. 5-hydroxytryptamine (5-HT), plays an important role in the pathophysiology of cold-induced vasospasm. Our objective was to study the effect of cooling on the 5-HT vascular response, classify the involved 5-HT receptors, and to analyze the role of the endothelium. Ring segments from the rat jugular vein, a preparation without alpha-adr
Background: Less than half of patients with major depressive disorder (MDD) respond to their first antidepressant trial. Our understanding of the underlying mechanisms of selective serotonin reuptake inhibitors (SSRIs) remains poor, and there is no reliable method of predicting treatment response. Methods: Thirty-seven MDD subjects and 41 healthy controls, somatically healthy and medication-free f
OBJECTIVE: To determine whether different tests of the adrenocorticotropic hormone (ACTH) reserve are influenced by diabetic state and metabolic control in newly diagnosed type 1 diabetic patients. DESIGN AND METHODS: We evaluated the ACTH reserve in 10 patients with uncomplicated type 1 diabetes during periods of poor and improved metabolic control and in 10 healthy subjects. The ACTH-cortisol se
The speed at which the number of battery electric vehicles is growing is fueling debates and research on the criticality of battery materials. But rapid growth also enables fast uptake of new cathode chemistries, and electric vehicle batteries show considerable flexibility and material substitutability. Historical scaling of production is more dynamic than recognized in scenarios of future mineral
Ubiquitination is a post-translational modification process that has a very important role in the homeostasis of eukaryotic cells. Linkage-specific ubiquitination determines the final destination of modified protein. Ubiquitination has also been reported to regulate inflammasome function and IL-1β degradation. Secretion of IL-1β by macrophages in response to inflammasome activation is a key proces
Some colours might have different connotations depending on people’s cultural backgrounds. When talking about evacuation, the colour employed for exit signs and flashing lights plays a significant role because it is responsible for conveying a message to the evacuees, either danger or safety. The aims of this study are to evaluate the influence of red and green emergency way-finding systems on the
Popular Abstract in Swedish Dekompressionssjuka (DCS) är ett tillstånd som kan uppkomma när man utsätts för en hastig sänkning av omgivningstrycket. Bakgrunden till tillståndet är att vävnadslagrad gas frisätts till blodbanan och där på olika sätt kan ge upphov till symptom från lätta hudbesvär till livshotande påverkan på det centrala nervsystemet. Vid atmosfärstryck är gasinnehållet i kroppens vReductions in ambient pressure liberates gas in various tissues and can result in decompression illness. In this thesis the patophysiological implications of a blood gas interface resulting from decompression was investigated with reference to the influence on biochemical mediators of inflammation. In a series of experiments, animals and human subjects have been exposed to hyperbaric trauma of dif
Competition among phytoplankton for limiting resources may involve direct or indirect interactions. A direct interaction of competitors is the release of chemicals that inhibit other species, a process known as allelopathy. Here, we investigated the allelopathic effect of three toxic microalgae species (Alexandrium tamarense, Karenia mikimotoi and Chrysochromulina polylepis) on a natural populatio
Background: Surgical trauma evokes a systemic cytokine response which is enhanced in patients with colorectal cancer. The aim of this study was to locate the origin of the systemic cytokine response to colorectal surgery. Methods: The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were analysed in systemic and mesenteric venous blood in 12 patients operated on
The article is a response to a lecture held by Sarah Coakley at Lund University 2009. In relation to Coakley's reflections on pain, the article addresses the question whether the Passion story still today, and not only in an ecclesial context, can serve as an incitement to a kind of self-examinating reflection. In other words, is it possible to retrieve through the Passion a narrative framework wh
Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similaritie
We present a comparative study of xanthorhodopsin, a proton pump with the carotenoid salinixanthin serving as an antenna, and the closely related bacteriorhodopsin. Upon excitation of retinal, xanthorhodopsin exhibits a wavy transient absorption pattern in the region between 470 and 540 nm. We interpret this signal as due to electrochromic effect of the transient electric field of excited retinal
The rebuttal by Reber and Alcock (2019a,b) to an umbrella review of multiple meta-analyses on the evidence for parapsychological (psi) phenomena (Cardeña 2018) did not engage deliberately with its data or analyses. Instead, the authors proposed that because they and some physicists consider psi phenomena to be impossible, “the data are irrelevant” (Reber & Alcock 2019b). After presenting some
