Filtyp
We present a comparative study of xanthorhodopsin, a proton pump with the carotenoid salinixanthin serving as an antenna, and the closely related bacteriorhodopsin. Upon excitation of retinal, xanthorhodopsin exhibits a wavy transient absorption pattern in the region between 470 and 540 nm. We interpret this signal as due to electrochromic effect of the transient electric field of excited retinal
The rebuttal by Reber and Alcock (2019a,b) to an umbrella review of multiple meta-analyses on the evidence for parapsychological (psi) phenomena (Cardeña 2018) did not engage deliberately with its data or analyses. Instead, the authors proposed that because they and some physicists consider psi phenomena to be impossible, “the data are irrelevant” (Reber & Alcock 2019b). After presenting some
Permafrost contains about 50% of the global soil carbon. It is thought that the thawing of permafrost can lead to a loss of soil carbon in the form of methane and carbon dioxide emissions. The magnitude of the resulting positive climate feedback of such greenhouse gas emissions is still unknown and may to a large extent depend on the poorly understood role of microbial community composition in reg
Background: The SYNAPSE study (NCT03085797) demonstrated that mepolizumab decreased nasal polyp (NP) size and nasal obstruction in patients with chronic rhinosinusitis with NP (CRSwNP). Methods: SYNAPSE, a randomized, double-blind study, included patients with recurrent, refractory, severe CRSwNP, eligible for repeated surgery despite receiving standard of care (SoC). Patients received 4-weekly me
In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with
Purpose of Review: The Arctic has experienced the most rapid change in climate of anywhere on Earth, and these changes are certain to drive changes in the carbon budget of the Arctic as vegetation changes, soils warm, fires become more frequent, and wetlands evolve as permafrost thaws. In this study, we review the extensive evidence for Arctic climate change and effects on the carbon cycle. In add
Plant-soil feedback is increasingly recognized as a vital framework to analyze multi-trophic interactions involving herbivores, plants and microbes, but research is still lacking on understanding such feedback in the context of global change. In grasslands, patterns of herbivory are expected to be affected by global change, further modifying existing plant-soil feedbacks. We tested this by evaluat
Fluvial export of organic matter from the terrestrial catchment to the aquatic system is a large and increasing carbon flux. The successful reduction in sulfuric acid deposition since the 1980s has been shown to enhance the mobility of organic matter in the soil, with more terrestrially derived dissolved organic matter (DOM) reaching aquatic systems. Changes in soil acidity also affect the quality
Brain pericytes not only maintain the anatomical, biochemical and immune blood-brain barrier, but display features of mesenchymal stem cells (MSCs) in vitro. MSCs have pro-regenerative properties attributed to their secretome. However, whether also brain pericytes possess such pro-regenerative capacities is largely unknown. Here we characterize the secretome and microvesicle (MV) release of human
For a better understanding of the effects of regional groundwater management for different land-use types on nitrogen content in groundwater, we investigated the Miyakonojo River Basin in south of Japan where the Nitrate Directive Plan has been in practice since 2004. For this purpose, we used nitrogen concentrations from 420 wells between 2000 and 2017 together with 8 different land-use categoriz
Recurrent ear infection in children during pre-school years is an important public health problem. Common advice given to parents is to minimize exposure of susceptible children to crowding and air pollution. This study aimed at investigating what changes parents undertake to improve the health of an otitis-prone child. Parents of children with 5 events before age thirty months (index children; n
Heart period variability and heart rate were studied in 15 women and 15 men while they were viewing negatively (snakes/spiders), neutrally (scenic views), and positively (cats and kittens/puppies and dogs) valenced films. Time-frequency analyses of the heart period variability power spectrum in the high frequency region (0.12-0.4 Hz), reflecting respiratory sinus arrhythmia (RSA), were carried out
This is "an account of variable responses from Swedish municipalities in terms of both adaptation and mitigation measures. By looking at the relationships between national and municipal policies, Langlais examines the adaptation barriers and acknowledges the role of 'visionary individuals' in some municipalities for initiating local actions unders similar institutional and governance conditions. H
