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Background: Disease-modifying therapies targeting the diverse pathophysiology of Alzheimer’s disease (AD), including neuroinflammation, represent potentially important and novel approaches. The glucagon-like peptide-1 receptor agonist semaglutide is approved for the treatment of type 2 diabetes and obesity and has an established safety profile. Semaglutide may have a disease-modifying, neuroprotec

INTRODUCTION: Ageing right care(fully) is a transnational research study which explores and maps an understanding of the care pathways between ageing in place and hospital at home policy and practices for older adults in Israel, the Netherlands and Sweden. The countries are suited to be compared where they have growing, ageing populations, a focus on healthcare reform and several policies to reduc

Drug side effects (DSEs) or adverse drug reactions (ADRs) are a major concern in the healthcare industry, accounting for a significant number of annual deaths in Europe alone. Identifying and predicting DSEs early in the drug development process is crucial to mitigate their impact on public health and reduce the time and costs associated with drug development. Objective: In this study, our primary

All over the world there is a shortage of adequate, affordable housing that enables social integration and sustainability. Many individuals and households have access to housing but live in different kinds of involuntary isolation with respect to age, gender, income, culture and ethnic background. There is a lack of housing forms that can contribute to solving these societal challenges through dif

The present study was designed to determine the interrelationships between sex, weaning age, and weaning weight on aspects of physiological and gastrointestinal development in pigs. Forty-eight Large White x Landrace pigs were used in a factorial arrangement with the respective factors being: age at weaning ( 14 or 28 days), weight at weaning ( heavy or light), sex ( boar or gilt), and time after

The polska, under lots of different spellings and titles, was the dominant music and dance repertoire in Sweden for nearly 300 years. The main purpose of this thesis has been to clarify some of the principal characteristics in both its dance and music forms. The thesis has both a historical and an ethnomusicological perspective and moves in the intersection between different types of traditional m

This thesis consists of three essays on VIX futures and options, and deals with issues highly relevant to all financial markets, such as understanding the operation of markets and developing flexible and tractable pricing models for contracts traded in them. It consists of four chapters. Chapter 1 provides a short introduction to the VIX and a brief explanation of how the old and new VIX are cons

Culture has, during the last two decades or so, come to influence historical research in such a way that it is no understatement to speak of "the cultural turn", a change in paradigm fully comparable to "the social turn" in the 1960s. Cultural history, as a concept, has changed over time, from a classic cultural history in the first part of the twentieth century, where culture is seen as "the grea

Antimicrobial peptides represent a heterogeneous group that displays multiple modes of action such as bacteriostatic, microbicidal and cytolytic properties that are sequence and concentration dependent. Life threatening infectious disease is now a worldwide crisis and treating them effectively is becoming difficult day by day, due to the emergence of antibiotic resistant strains at alarming rates.

Statistical analysis of long-term morphological data on coastal sedimentary features provides important information on the processes governing these features and their evolution in space and time. In this paper, seasonal, yearly and decadal (i.e. long-term) behavior of coastal morphological features is derived from field data by using both simple and advanced statistical techniques. The sedimentar

Traumatic brain injury (TBI) is one of the leading causes of death in children worldwide. Emerging evidence suggests that alterations in mitochondrial function are critical components of secondary injury cascade initiated by TBI that propogates neurodegeneration and limits neuroregeneration. Unfortunately, there is very little known about the cerebral mitochondrial bioenergetic response from the i

This article deals with Gerhard Oestreich's concept of 'Sozialdisziplinierung' and its possible status as a challenger to the two main schools within the Swedish state of research concerning the Early Modern state-building process. These main streams in Swedish historical research concists of the Interventionists, who argue for the state's more or less brutal intervention in the local autonomous s

Popular Abstract in Swedish Cancer är på cellnivå en genetisk sjukdom, i det avseendet att typiska egenskaper för cancerceller, t ex okontrollerad celldelning samt abnorm känslighet för yttre regulatoriska signaler, uppkommer genom förvärvade och ibland ärftliga förändringar, s k mutationer, i cellens arvsmassa. Hur mutationerna uppstår är bara till viss del känt. Somliga förändringar beror på strAcquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent structural and numerical aberrations. However, two of the most frequently occurring chromosome mutations in malignant and benign solid tumors, i.e., trisomy 7 and rearrangements of 12q13-15, have recently been

Colorectal cancers are globally ranked as the third most common cancer form in terms of incidence and mortality. Diet has long been considered as one of the main factors affecting population outcome regarding development of cancer in the colon. Numerous epidemiological studies have found links between consumption of dietary fibres and milk and reduced risk of cancers including colon cancer. To be

With her 1953 debut Anna Rydstedt (1928-1994) immediately became part of a strong tradition of Swedish women poets, a tradition represented by authors such as Karin Boye and Edith Södergran. The debut was a furious attack on those who had thwarted her attempts to become a minister in the Church of Sweden. Rydstedt’s poetry is always existential, both in its content and process. Writing, for her, i

Popular Abstract in Swedish Den svenska grundskolan har under de senaste åren genomgått och genomgår fortfarande en stark utveckling inom ramen för den allmänna decentraliseringen i samhället. Beslut och ansvar läggs allt längre ner i organisationen. De krav som ställdes på en skolledare tillbaka i tiden var i första hand att han skulle vara administratör och den som bevakade att skolans verk-samThe issues of the study are: How do the assistant principals face the work as school leaders? Which demands of competence do the new school leaders face? Which needs of competence development exist for new school leaders? In the school studied the organization of the management was changed from one principal and one director of studies to one principal and six assistant principals. All of these we

All cellular organisms in aquatic environments are susceptible to virus attack. Viruses are the smallest but most abundant biological entities in freshwaters. This thesis describes interactions between viruses and bacteria in temperate and polar freshwaters with particular emphasis on Arctic and Antarctic aquatic systems. Free virus-like particles in freshwaters are vulnerable and exposed and as p

Popular Abstract in Swedish Avhandlingens syfte är att genom en empirisk undersökning öka förståelsen av tidigt föräldraskap till barn med Downs syndrom. Jag utgår ifrån föräldrarnas livsvärld och utvecklar ett medföljande arbetssätt. Tio familjer med nyfödda barn med Downs syndrom följs genom regelbundna hembesök under det första året med barnet. Tillsammans med en medarbetare samtalar jag med föThe purpose of this dissertation was to increase - through an empirical investigation - our understanding of early parenthood in relation to children with Down syndrome. My point of departure has been the parents’ life-worlds, and I have developed an accompanying working method. Ten families with newborn infants with Down syndrome were followed through regular home visits during the first year of

The Storo greenstone belt in Godthabsfjord, southern West Greenland consists of juxtaposed rock units of different age and origin, and hosts gold mineralisation that is associated with arsenopyrite along a contact between lithological units and along the axial plane of a large fold core. The age and origin of the gold is debatable, but in this paper, we present new arsenopyrite Re-Os and zircon U-

Atmospheric organic aerosols are generally classified as primary and secondary (POA and SOA) according to their formation processes. An actual separation, however, is challenging when the timescales of emission and gas-to-particle formation overlap. The presence of SOA formation in biomass burning plumes leads to scientific questions about whether the oxidized fraction of biomass burning aerosol i