Filtyp
The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitocho
Circular oriented innovation commonly requires collaboration. Yet, to date, circular research lacks empirical investigation into collaborative processes. Collaborative processes are, however, highly researched within strategic management literature, thus offering valuable insights. The purpose of this paper is to investigate, identify and order the processes that companies undertake when designing
The recent release of improved lattice data has revived again the interest on precise theoretical calculations of the direct CP-violation ratio ε0/ε. We present a complete update of the Standard Model prediction [1,2], including a new re-analysis of isospin-breaking corrections which are of vital importance in the theoretical determination of this observable. The Standard Model prediction, Re(ε0/ε
To demonstrate and support sustainability of large-scale infrastructure projects, life cycle assessment (LCA) has become a common tool used in the evaluation of environmental impact. However, LCA includes a number of phases, which are all associated with uncertainties. Decisions made without regard to these uncertainties may be suboptimal and/or misleading. The current paper discusses some importa
Utopia – the word is simultaneously evocative of hope and dread. As a concept it is stupendously problematic, and yet despite its alleged passing into irrelevance, utopia still remains a household word. Why is this so?Utopia has been reduced to a category. We place a solution in the category of the utopian or, conversely, the not-utopian. Without fail, discussions involving utopia will eventually
The Swedish system for public quality control of structural design of buildings is one of the most liberal in the world. The full responsibility for this is given to the client in a building project. Consequences of this system are discussed in this paper via a case study of a recent collapse of a three-storey building. A number of gross errors in design and execution are described followed by a d
Development of optical techniques in medical applications can be difficult due to limited access to realistic phantoms. Here a 3-D printed model based on CT-images of the thorax of an infant is developed and tested.
The aerobic respiratory system of Bacillus subtilis 168 is known to contain three terminal oxidases: cytochrome caa3, which is a cytochrome c oxidase, and cytochrome aa3 and bd, which are quinol oxidases. The presence of a possible fourth oxidase in the bacterium was investigated using a constructed mutant, LUH27, that lacks the aa3 and caa3 terminal oxidases and is also deficient in succinate:men
Objective: The aim of this study was to evaluate clinically relevant complications within 14 days after extracorporeal shockwave lithotripsy (ESWL) in a modern setting. Materials and methods: Consecutive ESWL treatments between 2009 and 2015 in Ängelholm Hospital, Sweden, were analyzed retrospectively. The primary outcome was complications in patients seeking medical attention within 14 days after
Computational approaches have been major drivers behind the progress of proteomics in recent years. The aim of this white paper is to provide a framework for integrating computational proteomics into ELIXIR in the near future, and thus to broaden the portfolio of omics technologies supported by this European distributed infrastructure. This white paper is the direct result of a strategy meeting on
Background We attempt to develop a relatively comprehensive structural model of risk factors for drug abuse (DA) in Swedish men that illustrates developmental and mediational processes. Methods We examined 20 risk factors for DA in 48,369 men undergoing conscription examinations in 1969–70 followed until 2011 when 2.34% (n = 1134) of them had DA ascertained in medical, criminal and pharmacy regist
Objectives: The purpose of this presentation is to present the development, activities and achievements of the NOPHO/NOBOS Working Group on Ethics (WGE) 2008-2013. Methods: A joint working group on ethics, consisting of pediatric oncology nurses and physicians, was constituted during the NOPHO/NOBOS Annual Meeting in 2008. The intention was to create a Nordic competence group addressing ethical qu
Practice theory roughly argues that the material world and the cultural world continuously interact and co-constitute one another. However, existing research methods on consumer behaviors tend to separatethese two dimensions and show a preference toward concentrating on only one of them. Video ethnography as a medium has the potential to capture these two world
A modularized approach to modeling of harmonics in electrical distribution networks at steady state is presented. It is based on harmonic balance and exploits that the loads in a distribution network are connected in parallel in such a way that their operating conditions are approximately known in advance (e.g. 230 V, 50 Hz) and the harmonic distortion of the voltage is limited. The model for a co
Seattle is currently the fastest growing city in the United States attracting a large pool of young international professionals – many of whom are working in the IT industry. However, Seattle is also home to a large Nordic community, immigrants once attracted by the agricultural, forestry, and fishing industries. At present however, the city is pulling in a highly educated young Nordic population
A Swedish pedigree with an autosomal dominant inheritance of idiopathic scoliosis was initially studied by genetic linkage analysis, prioritising genomic regions for further analysis. This revealed a locus on chromosome 1 with a putative risk haplotype shared by all affected individuals. Two affected individuals were subsequently exome-sequenced, identifying a rare, non-synonymous variant in the C
P4 ATPase flippases translocate phospholipids across biomembranes, thus contributing to the establishment of transmembrane lipid asymmetry, a feature important for multiple cellular processes. The mechanism by which such phospholipid flipping occurs remains elusive as P4 ATPases transport a giant substrate very different from that of other P-type ATPases such as Na+/K+-and Ca2+-ATPases. Based on a
