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Introduction: Gallbladder carcinoma is about 0.5% of all cancer. The outcome of patients with gallbladder carcinoma is overall bad and the only potentially curative treatment is surgery. The aim of this study was to determine the disease's prevalence in Iceland and outcome of the patients diagnosed in the study period.Patients and methods: This was a retrospective study of all diagnosed patients w
Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and hear
Business models direct a firm’s activity to move in coherence with the objectives of the business. Current literature suggests business models can act as vital forces to facilitate sustain-ability transitions and highlights the urgent research call to understand the role of business model innovations in stimulating sustainability transitions. This paper addresses this research need by investigatin
The treatment of intershell interactions remains a major challenge in the theoretical description of strongly correlated materials. Most previous approaches considered the influence of intershell interactions at best in a static fashion, neglecting dynamic effects. In this paper, we propose a slave-rotor method that goes beyond this approximation by incorporating the effect of intershell interacti
The zooarchaeological record of Iron Age Scania in south Sweden is rich and multi-faceted; within it are many clues to past human-animal relations. This book focusses on the management of cattle, sheep, pig and horse, and Scania, withits environmentally diverse composition, make up the study region for this topic, in which the author tries to give old bones new life by putting them in an archaeolo
Protein tyrosine phosphatase 1B (PTP1B) is an important drug target for the treatment of type II diabetes and obesity. There are strong indications that a novel class of allosteric inhibitors act by preventing the closure of the WPD-loop [C. Wiesmann, K.J. Barr, J. Kung, J. Zhu, D.A. Erlanson, W. Shen, B.J. Fahr, M. Zhong, L. Taylor, M. Randall, R.S. McDowell, S.K. Hansen, Allosteric inhibition of
Purpose: Tourism faces a range of interconnected and potentially transformative global risks – collectively considered an evolving polycrisis – that have not been adequately defined and understood. As a result, the industry struggles to proactively anticipate and mitigate potential future challenges, while governments lack insight for strategic longer-term decision-making on tourism development. T
At three uranium (U) legacy sites in Kyrgyzstan, namely, Kadji Sai, Mailuu-Suu and Sumsar, an initial human bio-monitoring programme was introduced as a complementary activity to environmental impact studies in these areas. The aim was to assess trace element (TE) contents in blood and genetic susceptibility for Pb as one of the contaminants. The programme included the determination of 9 TE in blo
LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine
Collaboration between public and private partners is often seen as an important tool and is used by public authorities to handle many different problems in society, including public transport. In both research and practice, it is common to find exhortations to increase collaboration and suggestions on how to improve it and make it successful. However, in this chapter, we adopt a critical approach
In this editorial, we discuss why disclosure of many aspects commonly seen in positionality statements may be problematic given the cultural and legal context surrounding personal information in Europe, and the unequal distribution of required bravery, experienced burdens and barriers. We summarize current norms and problems with requiring labels, and suggest that, rather than disclosing identity
The importance of older adults’ participation in policymaking is increasingly recognized, but the nuanced participation processes remain insufficiently understood. This scoping review aims to map existing research on older adults’ participation in policymaking, focusing on who participates, their activities and contributions, resulting outputs and outcomes, and the enablers and barriers affecting
One of the most important topics in financial literature is the Efficient Market Hypothesis (EMH). Recent financial research has questioned this hypothesis, and many authors have reached the conclusion that a contrarian strategy creates abnormal positive returns. In other words a strategy profiting buying losers and selling winners. To explain this market behaviour researchers have come up with a
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House prices and their movements are a topic of much interest in today’s society. Most of the population in a country is affected by house price movements in one way or another. The debate mostly focuses on house price bubbles. In this thesis it is argued that the debate should widen its focus. During times of crises, house prices’ conditional variance increases and this harms the economy. Thus it
