Filtyp
Determining the child’s best interests in a hospital setting will ideally involve the combined views of children, parents, and healthcare professionals. However, few studies have explored parents’ experiences of their child’s best interests when they engage with the healthcare system. Therefore, this study aimed to explore parents’ experiences of their child’s best interests during hospitalisation
Background: Palliative care (PC) is an integral part of cancer treatment. However, data on service availability is limited in childhood cancers. Aim: To describe the availability of PC services in paediatric oncology centres across Europe, and to identify barriers and facilitators for implementing and providing paediatric palliative care (PPC). Methods: Paediatric oncology centres across Europe we
An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal mass spectrometry-based strategy for in-depth characterization of antigen–antibody complexes to enable the identification of protective epitopes using the cytolytic exotoxin
Understanding the attachment owners can feel to their robot vacuums, which also map and collect data about their homes, is key to understanding the ambivalences involved in the integration of automated visualities in the home. Drawing on qualitative video interviews and observations of people interacting with their robot vacuums, this article identifies three key factors in understanding how cohab
Background: Natural resource extraction projects can have positive but also negative effects on the health of affected communities, governed by demographic, economic, environmental, physical and social changes. Negative effects often prevail and these might widen existing health inequities. Health impact assessment (HIA) is a decision-support tool that aims at maximizing benefits and minimizing ne
Background: Dysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA). Citrullination is induced by immune cell-derived peptidyl-Arg deiminases (PADs), which are overactivated in the inflamed synovium. We characterized the effect of PAD2- and PAD4-induced citrullination on the abi
Space tourism is an industry with risks including health and safety, space debris, biological hazards, and sustainability concerns. However, there is limited research on the perceived risk of participation in space tourism, particularly regarding age and gender differences. An integrated research model was created and tested with four perceived risk dimensions using fuzzy-set Qualitative Comparati
This paper treats the problem of control signal saturation caused by feedforward control from measurable load disturbances. An efficient feedforward compensator will often give significant peaks in the control signal at fast changes in the load disturbance. These peaks may cause the control signal to reach a saturation limit. In the paper, it is shown that the anti-windup function may cause unnece
Future exemplary education should foster inclusive and respectful learning environments to meet new challenges like digital inequality and power concentration. In the new normal of education due to COVID-19, inclusive online disaster risk reduction (DRR) education is essential. Therefore, this article aims to investigate the current status quo of inclusive online and distance DRR education and its
Context: Whether patients with Cushing disease (CD) in remission have increased mortality is still debatable.Objective: To study overall and disease-specific mortality and predictive factors in an unselected nationwide cohort of patients with CD.Design, patients, and methods: A retrospective study of patients diagnosed with CD, identified in the Swedish National Patient Registry between 1987 and 2
Adaptation to different ecological niches is considered one of the main drivers of species diversification, also in cryptic species complexes, notwithstanding their morphological stasis. We here review all the published information on ecological differentiation within cryptic species complexes within the phylum Rotifera. We found 177 instances of cryptic species identified genetically, published i
Recent years have seen an explosion in social media in our everyday lives, and a corresponding increase in social media research in IS. As social media researchers, we are intrigued by the problem of virtuality and context in social media research, and how we might apply reflexive research principles to such settings. In social media, the absence of a setting's real physical boundaries (to a large
Glacio-hydrological modeling is a key task for assessing the influence of snow and glaciers on water resources, essential for water resources management. The present study aims to enhance a conceptual hydrological model (namely Glacial Snow Melt (GSM)) by data-driven and swarm computing for enhancing the accuracy of rainfall runoff prediction. The proposed framework combines the conceptual hydrolo
Purpose: To illustrate the technique of antegrade in situ laser fenestration (ISLF) on a predesign custom-manufactured stent-graft with single reinforced fenestration for use in emergency endovascular repair of complex abdominal aortic aneurysms (AAAs). Technique: A short custom-made device (CMD) fenestrated graft was predesigned with a single preloaded 8 mm strut-free fenestration at 12 o’clock p
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platele
This is an experiment the perceptual differences between full and contractedsemi-modals in English, i.e. the distinction of going to vs gonna and (HAVE) gotto vs gotta. It is a listen-and-repeat experiment and is informed by the findingsof a corpus study of the use of these forms in American English (AmE). It thusaims to integrate the social/variational and the cognitive sides of the phenomenon.
A cross-valley beach terrace in Iladalen in the south-eastern corner of Barentsøya (Svalbard) is interpreted as built by long-shore sediment transport and deposition, with its maximum height at 88 m a.s.l., marking the marine limit (ML) at deglaciation. A whale vertebra (most probably from a bowhead whale, Balaena mysticetus) was found embedded in the upper part of the littoral sediments at a hei
The demand for user participation in design processes is increasing, and there is a need to formulate guidance on how to involve disabled users and their representative organisations. Their participation contributes an extreme user perspective to the design process. The aim of this study was to develop an empirically grounded framework for user participation in co-design processes, involving the u
BACKGROUND: Health systems resilience (HSR) research is a rapidly expanding field, in which key concepts are discussed and theoretical frameworks are emerging with vibrant debate. Fragile and conflict-affected settings (FCAS) are contexts exposed to compounding stressors, for which resilience is an important characteristic. However, only limited evidence has been generated in such settings. We con
